Abstract:
:Synthesis and storage of thyroglobulin as well as synthesis of thyroid hormones and their release into the circulation are important functions of thyroid, which were studied in fine needle aspiration (FNA) smears from thyroid lesions. Evidence of thyroglobulin synthesis was demonstrated in neoplastic and nonneoplastic follicular cells, especially in Hürthle cells, in the form of colloid inclusions. Whereas the pinocytic vesicles containing colloid at the luminal end of in nonneoplastic and neoplastic follicular cells indicated engulfment of colloid for synthesis of thyroid hormones (T3 and T4), the marginal vacuoles (MVs) (fire-flare appearance) at the basal aspects of follicular cells suggested their release on way to the interfollicular capillaries. The morphological evidence of secretary activity could also be demonstrated in medullary thyroid carcinoma (MTC) in the form of azurophilic granules, marginal vacuoles, and intracytoplasmic lumina (ICL) with secretions; the secretory material, likely to be amyloid, present in MTC cells, and their release to the extracellular space was confirmed by positive immunocytochemical staining for calcitonin. It was found that nuclear grooves and related intranuclear cytoplasmic inclusions (INCIs) in papillary thyroid carcinoma (PTC) possibly represent an initial step of a degenerative process leading to formation of inactive cerebriform nuclei. Based on observation regarding formation and release of precursor substances for psammoma bodies (PBs), it was also suggested that PBs may not represent a process of dystrophic calcification over infarcted/dead papillae but suggest an active biological process, which leads to inhibition of growth of neoplastic cells and acts as a barrier against spread of PTC.
journal_name
J Cytoljournal_title
Journal of cytologyauthors
Das DKdoi
10.4103/JOC.JOC_43_18subject
Has Abstractpub_date
2018-07-01 00:00:00pages
131-138issue
3eissn
0970-9371issn
0974-5165pii
JCytol-35-131journal_volume
35pub_type
杂志文章,评审abstract:Context:Fine needle aspiration (FNA) plays a crucial role in the evaluation of patients with thyroid lesions. The Bethesda system for reporting thyroid cytopathology (TBSRTC) was designed with a mission to standardize the process of diagnosis and management of thyroid lesions by FNA cytology (FNAC). Aim:We aim to see ...
journal_title:Journal of cytology
pub_type: 杂志文章
doi:10.4103/JOC.JOC_64_18
更新日期:2019-01-01 00:00:00
abstract:Background:Micronucleus (MN) is an extranuclear body within the cell formed due to failure of incorporation of whole chromosomes or their fragments during cell division. MN scoring can be done to identify malignant effusions. Aims:This study aimed to score micronuclei to distinguish malignant effusion from benign effu...
journal_title:Journal of cytology
pub_type: 杂志文章
doi:10.4103/JOC.JOC_42_19
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Urine excreted by the body has a variable composition in different physiological and pathological conditions. The cells that come from the renal pelvis, ureters, bladder, and urethra are carried by the urine, and therefore, they can be observed in fresh samples and in smears with Giemsa and Papanicolaou stai...
journal_title:Journal of cytology
pub_type: 杂志文章
doi:10.4103/0970-9371.130666
更新日期:2014-01-01 00:00:00
abstract::Castleman's disease (CD), also called giant lymph nodal hyperplasia, is a lymphoproliferative disorder secondary to lymphoid follicle hyperplasia and marked capillary proliferation with endothelial hyperplasia. It presents as enlarged lymph nodes in the mediastinum, neck, groin, axilla and other sites. On clinical exa...
journal_title:Journal of cytology
pub_type:
doi:10.4103/0970-9371.73306
更新日期:2010-10-01 00:00:00
abstract::Collagenous spherulosis is a rare entity usually seen in association with benign breast lesions. It is often picked up incidentally with a reported incidence of about 0.2% in cytological material. There are very few reports describing cytomorphological features of collagenous spherulosis. To the best of our knowledge ...
journal_title:Journal of cytology
pub_type:
doi:10.4103/0970-9371.138683
更新日期:2014-04-01 00:00:00
abstract::Adult-type granulosa cell tumors (AGCT) account for 1-2% of all ovarian tumors and 95% of granulosa cell tumors. In AGCT, at the time of peritoneal washing, tumor cells are rarely seen to exfoliate and FIGO stage is raised from IA/IB or IIA/IIB to stage IC or IIC despite the absence of a gross intraepithelial tumor. P...
journal_title:Journal of cytology
pub_type:
doi:10.4103/0970-9371.107528
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:The role of DNA ploidy in genomic instability of cancer cells and prognosis has been described in a number of studies. The role of the centrosome in cell cycle has also been reported. AIM:In this study, we aimed to investigate the correlation between the centrosome and DNA ploidy in breast cancer in a searc...
journal_title:Journal of cytology
pub_type: 杂志文章
doi:10.4103/0970-9371.97150
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND:Micronuclei in exfoliated oral epithelial cells have been shown in some studies to correlate with severity of this genotoxic damage. This severity can be measured in terms of grading of the lesions. AIM:To correlate frequency of micronuclei (MN) in oral exfoliated cells in clinically diagnosed cases of oral...
journal_title:Journal of cytology
pub_type: 杂志文章
doi:10.4103/0970-9371.76941
更新日期:2011-01-01 00:00:00
abstract:Aims:Tzanck smear is an old but useful test for diagnosis of cutaneous dermatoses. The aim of this study was to highlight the potential usefulness and diagnostic pitfalls of Tzanck smear for diagnosis of cutaneous dermatoses and infections. Materials and Methods:This hospital based cross-sectional study was carried ou...
journal_title:Journal of cytology
pub_type: 杂志文章
doi:10.4103/JOC.JOC_88_16
更新日期:2017-10-01 00:00:00
abstract::Rosai-Dorfman disease, that is, sinus histiocytosis with massive lymphadenopathy is a benign systemic proliferative disorder of histiocytes. The typical clinical presentation of the disease includes bilateral painless massive lymphadenopathy, fever and polyclonal hypergammaglobulinemia. Extranodal involvement is prese...
journal_title:Journal of cytology
pub_type:
doi:10.4103/0970-9371.83473
更新日期:2011-07-01 00:00:00
abstract::Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) is a rare benign disease of unknown etiology presenting with massive lymphadenopathy. These cases can often be misdiagnosed as lymphoma. Hence, it is important to distinguish Rosai-Dorfman disease from lymphoma and other causes of histiocytosis b...
journal_title:Journal of cytology
pub_type:
doi:10.4103/0970-9371.55229
更新日期:2009-04-01 00:00:00
abstract::Primary malignant lymphomas of the salivary glands are rare, accounting for 2-5% of salivary gland tumors and 5% of extranodal lymphomas, frequently seen in the parotid gland. There are single case reports mentioned in the literature. Clinical presentation is not characteristic and the disease is often overlooked with...
journal_title:Journal of cytology
pub_type:
doi:10.4103/0970-9371.190441
更新日期:2016-10-01 00:00:00
abstract:Background:Cervical cancer is one of the most frequent malignancies in women. Micronucleus (MN) testing has gained popularity as a biomarker in early diagnosis of many types of cancer. Aims:This study aims to investigate the role of MN testing on early detection of cervical cancer and the effect of boron exposure on c...
journal_title:Journal of cytology
pub_type: 杂志文章
doi:10.4103/JOC.JOC_185_17
更新日期:2019-04-01 00:00:00
abstract::Intravascular papillary endothelial hyperplasia (IVPEH) is an unusual form of intravascular endothelial proliferation. Fine needle aspiration (FNA) diagnosis of IVPEH is quite challenging and only rare reports of the cytopathological features of this entity have been published. We report a case of a 55-year-old female...
journal_title:Journal of cytology
pub_type:
doi:10.4103/0970-9371.107512
更新日期:2013-01-01 00:00:00
abstract::Primary (spontaneous) umbilical endometriosis is very rare with an estimated incidence of 0.5-1% of all patients with endometrial ectopia. Endometriosis is a common gynecological condition, the pelvis being the most common site of the disease. Extrapelvic site is less common and even more difficult to diagnose due to ...
journal_title:Journal of cytology
pub_type:
doi:10.4103/0970-9371.86355
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND:Neuropathology centers are expected to offer a prompt and accurate intraoperative diagnosis regarding tumor/lesion type and grade on fresh unfixed tissue. Level of diagnostic accuracy according to type and grade and also, the experience at a new center has not been reported before. AIMS:The aim of this stud...
journal_title:Journal of cytology
pub_type: 杂志文章
doi:10.4103/0970-9371.117677
更新日期:2013-07-01 00:00:00
abstract::Lung cancer (LC) is the leading cause of cancer-related mortality. Unfortunately, most patients of LC present at the advanced stage of the disease with a poor prognosis and 1-year survival of less than 20%. At the advanced stage of the disease, surgical resection cannot be possible, hence small biopsy or cytology spec...
journal_title:Journal of cytology
pub_type: 杂志文章
doi:10.4103/JOC.JOC_135_18
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:Oral lichen planus (OLP) is one of the potentially malignant disorders (PMDs) with a malignancy rate of 0.2-2%. Aneuploidy is considered to be one of the important markers for malignant transformation and DNA-image cytometry (DIC) has been successfully employed in oral mucosal PMDs and also in tumors of the ...
journal_title:Journal of cytology
pub_type: 杂志文章
doi:10.4103/0970-9371.145629
更新日期:2014-07-01 00:00:00
abstract:BACKGROUND:The cytological examinations of serous effusions have been well-accepted, and a positive diagnosis is often considered as a definitive diagnosis. It helps in staging, prognosis and management of the patients in malignancies and also gives information about various inflammatory and non-inflammatory lesions. D...
journal_title:Journal of cytology
pub_type: 杂志文章
doi:10.4103/0970-9371.93210
更新日期:2012-01-01 00:00:00
abstract::Chondroid syringoma is a rare benign adnexal tumor of sweat glands with microscopic resemblance to the salivary gland pleomorphic adenoma. Cytology is rarely utilized for preoperative assessment of these slow-growing, small, nodular lesions. Definitive cytological diagnosis is also quite difficult, and majority of the...
journal_title:Journal of cytology
pub_type:
doi:10.4103/0970-9371.145659
更新日期:2014-07-01 00:00:00
abstract:Background:Skin adnexal neoplasms are relatively rare and thus uncommonly encountered in routine pathology practice. Aims:The present study was conducted with the aim to diagnose various skin adnexal tumors on fine-needle aspiration cytology (FNAC) followed by confirmation on histopathology and immunohistochemistry of...
journal_title:Journal of cytology
pub_type: 杂志文章
doi:10.4103/JOC.JOC_63_17
更新日期:2018-10-01 00:00:00
abstract::Salivary gland cytopathology is a diagnostically challenging area with overlapping cytomorphological features between benign, malignant, and metastatic tumors. We report the case of 45-year-old male who presented with two swellings in right retroauricular and infraauricular region along with a palpable single right ce...
journal_title:Journal of cytology
pub_type:
doi:10.4103/0970-9371.203576
更新日期:2017-04-01 00:00:00
abstract::Preoperative pathologic diagnosis of pelvic tumors is mandatory for proper management of patients like neoadjuvant chemotherapy and interval debulking. Currently there are many minimally invasive methods available which include fine-needle aspiration cytology (FNAC) and trucut biopsy, mostly complimentary to each othe...
journal_title:Journal of cytology
pub_type: 杂志文章
doi:10.4103/JOC.JOC_63_18
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:Cancer of the cervix has been considered as one of the preventable cancers. This study is the first published research addressing the screening of cancer of the cervix in the eastern region of Saudi Arabia. AIM:This study aims to detect the prevalence of abnormal epithelial changes and its types in the east...
journal_title:Journal of cytology
pub_type: 杂志文章
doi:10.4103/0970-9371.86343
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVE:The present study is designed to evaluate the role of pleural fluid analysis in diagnosing pleural diseases and to study the advantages and disadvantages of thoracocentasis and pleural biopsy. MATERIALS AND METHODS:We prospectively included 66 consecutive indoor patients over a duration of 1 year. Pleural fl...
journal_title:Journal of cytology
pub_type: 杂志文章
doi:10.4103/0970-9371.188062
更新日期:2016-07-01 00:00:00
abstract::The incidence of primary papillary carcinoma arising in thyroglossal cyst is rare and occurs in <1% of thyroglossal cysts. Even rarer is its diagnosis by pre-operative fine needle aspiration cytology (FNAC). Only 15 such cases diagnosed by FNAC have been previously reported in the literature. In this article, cytomorp...
journal_title:Journal of cytology
pub_type:
doi:10.4103/0970-9371.66697
更新日期:2010-01-01 00:00:00
abstract:INTRODUCTION:Cervical intraepithelial neoplasia and cervical cancer remain important health problems. Cervical cytology by Papanicolaou (Pap) smears is an effective means of screening for cervical premalignant and malignant conditions. AIM:The aim of this study was to assess the prevalence of cervical dysplasia in pre...
journal_title:Journal of cytology
pub_type: 杂志文章
doi:10.4103/0970-9371.126659
更新日期:2013-10-01 00:00:00
abstract::Malignant mesothelioma of pleura is a locally aggressive rare neoplasm of mesothelial cells, which produces distant metastasis in advanced stages of its course. It is exceptional for patients to present with metastasis prior to the detection of primary tumor in the pleura. Here, we report a case of malignant mesotheli...
journal_title:Journal of cytology
pub_type:
doi:10.4103/0970-9371.216123
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:The use of oral exfoliative cytology as a diagnostic aid accentuates the need for establishing an accurate baseline, thereby enabling the comparison of abnormal oral tissue with established baseline. AIMS AND OBJECTIVE:To detect any changes in the nuclear area (NA), cytoplasmic area (CA), and nuclear:cytopl...
journal_title:Journal of cytology
pub_type: 杂志文章
doi:10.4103/0970-9371.80745
更新日期:2011-04-01 00:00:00
abstract::Primary lymphoma of the parotid gland is relatively rare and constitutes about 4-5% of extranodal lymphomas. The majority of them is non-Hodgkin lymphoma (NHL) and is B cell in nature. We report a case of primary diffuse large B-cell lymphoma (DLBCL) of the parotid gland in an elderly male. The case was diagnosed on f...
journal_title:Journal of cytology
pub_type:
doi:10.4103/0970-9371.182539
更新日期:2016-04-01 00:00:00