Abstract：
Background:Cervical cancer is one of the most frequent malignancies in women. Micronucleus (MN) testing has gained popularity as a biomarker in early diagnosis of many types of cancer. Aims:This study aims to investigate the role of MN testing on early detection of cervical cancer and the effect of boron exposure on cervical cells. Settings and Design:The study population comprised women who were diagnosed to be human papillomavirus (HPV)-positive and had atypical squamous cells of undetermined significance (ASCUS) as cervical cytology in a cervical screening project. A total of 15 HPV-positive and 36 ASCUS patients were identified. Randomly selected 20 women were selected from boron-rich region (n = 10) and nonboron region (n = 10). Materials and Methods:Cervical swab specimens were dyed using Papanicolaou (PAP) and May-Grünwalds-Giemsa (MGG) techniques, and MN count in 1000 cells was performed. The results were statistically evaluated. Statistical Analysis Used:Data were analyzed using Statistical Package for the Social Sciences (SPSS) version 13. Quantitative data were presented as mean ± standard deviation. MN test scoring was compared using Mann-Whitney U-test. Results:Boron content of urine was measured to be 3.02 ± 1.45 and 0.98 ± 0.42 mg/day in boron-rich and nonboron regions, respectively. When MN counts were compared according to PAP and MGG staining in HPV- and ASCUS-positive women, there was statistically no significant difference (P > 0.05). Disregarding regions, HPV/control and HPV/ASCUS cases stained with PAP and MGG had statistically significant difference in MN count (P < 0.05). Conclusion:These findings suggest that MGG and PAP staining gives similar results with regard to MN count. On the other hand, it has been shown again that HPV induces MN and causes genomic instability.
journal_name
J Cytoljournal_title
Journal of cytologyauthors
Yıldırım H,Göker A,Demirci H,Güvenal T,Korkmaz Mdoi
10.4103/JOC.JOC_185_17subject
Has Abstractpub_date
2019-04-01 00:00:00pages
75-78issue
2eissn
0970-9371issn
0974-5165pii
JCytol-36-75journal_volume
36pub_type
杂志文章abstract：Introduction:The mortality due to uterine cervical cancer has been gradually increasing in women under 40 years of age (U40) in Japan. We investigated the effect of high-risk human papillomavirus (HR-HPV) on U40 subjects without any overt cytological abnormalities. Materials and Methods:We retrospectively examined the...
journal_title：Journal of cytology
pub_type： 杂志文章
doi：10.4103/JOC.JOC_148_17
更新日期：2019-07-01 00:00:00
abstract：BACKGROUND:Fine needle aspiration cytology (FNAC) of oral and maxillofacial region has not been widely utilized for diagnosis due to diversity of lesion types, heterogeneity of cell populations and difficulties in reaching and aspirating these lesions. AIM:Our aim was to demonstrate the effectiveness of this cheap and...
journal_title：Journal of cytology
pub_type： 杂志文章
doi：10.4103/0970-9371.83461
更新日期：2011-07-01 00:00:00
abstract：Context:Intraoperative pathological assessment provides valuable information in a patient's diagnosis and management. Touch imprint/crush cytology is simple, rapid, and cost-effective. Also, imprint smears give excellent cytomorphology. Aims:To assess the utility and feasibility of intraoperative cytology technique as...
journal_title：Journal of cytology
pub_type： 杂志文章
doi：10.4103/JOC.JOC_94_19
更新日期：2020-07-01 00:00:00
abstract：:Primary (spontaneous) umbilical endometriosis is very rare with an estimated incidence of 0.5-1% of all patients with endometrial ectopia. Endometriosis is a common gynecological condition, the pelvis being the most common site of the disease. Extrapelvic site is less common and even more difficult to diagnose due to ...
journal_title：Journal of cytology
pub_type：
doi：10.4103/0970-9371.86355
更新日期：2011-10-01 00:00:00
abstract：INTRODUCTION:Cervical intraepithelial neoplasia and cervical cancer remain important health problems. Cervical cytology by Papanicolaou (Pap) smears is an effective means of screening for cervical premalignant and malignant conditions. AIM:The aim of this study was to assess the prevalence of cervical dysplasia in pre...
journal_title：Journal of cytology
pub_type： 杂志文章
doi：10.4103/0970-9371.126659
更新日期：2013-10-01 00:00:00
abstract：:Chondroid syringoma is a rare benign adnexal tumor of sweat glands with microscopic resemblance to the salivary gland pleomorphic adenoma. Cytology is rarely utilized for preoperative assessment of these slow-growing, small, nodular lesions. Definitive cytological diagnosis is also quite difficult, and majority of the...
journal_title：Journal of cytology
pub_type：
doi：10.4103/0970-9371.145659
更新日期：2014-07-01 00:00:00
abstract：:Tissue diagnosis of small round cell tumors relies heavily on immunohistochemical staining. Two of the small round cell tumors, namely neuroblastoma and primitive neuroectodermal tumor, have considerable morphologic overlap. Many studies suggest that CD99 positivity virtually excludes the diagnosis of neuroblastoma. W...
journal_title：Journal of cytology
pub_type：
doi：10.4103/0970-9371.97162
更新日期：2012-04-01 00:00:00
abstract：:Adult-type granulosa cell tumors (AGCT) account for 1-2% of all ovarian tumors and 95% of granulosa cell tumors. In AGCT, at the time of peritoneal washing, tumor cells are rarely seen to exfoliate and FIGO stage is raised from IA/IB or IIA/IIB to stage IC or IIC despite the absence of a gross intraepithelial tumor. P...
journal_title：Journal of cytology
pub_type：
doi：10.4103/0970-9371.107528
更新日期：2013-01-01 00:00:00
abstract：Context:Fine needle aspiration (FNA) plays a crucial role in the evaluation of patients with thyroid lesions. The Bethesda system for reporting thyroid cytopathology (TBSRTC) was designed with a mission to standardize the process of diagnosis and management of thyroid lesions by FNA cytology (FNAC). Aim:We aim to see ...
journal_title：Journal of cytology
pub_type： 杂志文章
doi：10.4103/JOC.JOC_64_18
更新日期：2019-01-01 00:00:00
abstract：:Rosai-Dorfman disease, that is, sinus histiocytosis with massive lymphadenopathy is a benign systemic proliferative disorder of histiocytes. The typical clinical presentation of the disease includes bilateral painless massive lymphadenopathy, fever and polyclonal hypergammaglobulinemia. Extranodal involvement is prese...
journal_title：Journal of cytology
pub_type：
doi：10.4103/0970-9371.83473
更新日期：2011-07-01 00:00:00
abstract：Background:Human papilloma virus (HPV) infection is the major etiologic agent of cervical carcinoma. The aim of this study was to determine the prevalence of HPV infection and genotype distribution in cervical swabs from 2,234 Turkish and 357 Albanian women with similar lifestyles from two different countries. Materia...
journal_title：Journal of cytology
pub_type： 杂志文章
doi：10.4103/JOC.JOC_162_17
更新日期：2018-10-01 00:00:00
abstract：:Primary malignant lymphomas of the salivary glands are rare, accounting for 2-5% of salivary gland tumors and 5% of extranodal lymphomas, frequently seen in the parotid gland. There are single case reports mentioned in the literature. Clinical presentation is not characteristic and the disease is often overlooked with...
journal_title：Journal of cytology
pub_type：
doi：10.4103/0970-9371.190441
更新日期：2016-10-01 00:00:00
abstract：Background:Micronucleus (MN) is an extranuclear body within the cell formed due to failure of incorporation of whole chromosomes or their fragments during cell division. MN scoring can be done to identify malignant effusions. Aims:This study aimed to score micronuclei to distinguish malignant effusion from benign effu...
journal_title：Journal of cytology
pub_type： 杂志文章
doi：10.4103/JOC.JOC_42_19
更新日期：2020-01-01 00:00:00
abstract：Background:Skin adnexal neoplasms are relatively rare and thus uncommonly encountered in routine pathology practice. Aims:The present study was conducted with the aim to diagnose various skin adnexal tumors on fine-needle aspiration cytology (FNAC) followed by confirmation on histopathology and immunohistochemistry of...
journal_title：Journal of cytology
pub_type： 杂志文章
doi：10.4103/JOC.JOC_63_17
更新日期：2018-10-01 00:00:00
abstract：BACKGROUND:It is now known that the disease process of diabetes has effects on various tissues of the body. The following study was done to analyze the effects of diabetes on oral tissues. AIMS:To study the morphology and cytomorphometry of the cells obtained in cytologic smears from the buccal mucosa of diabetic pati...
journal_title：Journal of cytology
pub_type： 杂志文章
doi：10.4103/0970-9371.73291
更新日期：2010-10-01 00:00:00
abstract：:Lung cancer (LC) is the leading cause of cancer-related mortality. Unfortunately, most patients of LC present at the advanced stage of the disease with a poor prognosis and 1-year survival of less than 20%. At the advanced stage of the disease, surgical resection cannot be possible, hence small biopsy or cytology spec...
journal_title：Journal of cytology
pub_type： 杂志文章
doi：10.4103/JOC.JOC_135_18
更新日期：2019-04-01 00:00:00
abstract：INTRODUCTION:Human immunodeficiency virus (HIV) infection has become a global pandemic. Persistent generalized lymphadenopathy (PGL) is very common manifestation of HIV infection. Moreover, different opportunistic infections such as tuberculosis (TB) and malignancies may present with lymphadenopathy. Mycobacterium aviu...
journal_title：Journal of cytology
pub_type： 杂志文章
doi：10.4103/0970-9371.182518
更新日期：2016-04-01 00:00:00
abstract：:A case of lymphoepithelial carcinoma (LEC) occurring in right submandibular gland of a 13-year-old Indian male is presented, wherein the lesion unveiled itself only after multiple fine needle aspiration (FNA) procedures. This unusual neoplasm has high frequency of occurrence in Eskimos and a predilection for the parot...
journal_title：Journal of cytology
pub_type：
doi：10.4103/0970-9371.101185
更新日期：2012-07-01 00:00:00
abstract：BACKGROUND:Liquid-based cytology (LBC) preparation is a way to improve and refine the fine-needle aspiration (FNA) samples. There are a few studies comparing LBC with conventional smear (CS). AIM:The present study was undertaken to evaluate the utility of manual LBC (MLBC) and CS preparations in various FNA samples. ...
journal_title：Journal of cytology
pub_type： 杂志文章
doi：10.4103/0970-9371.190446
更新日期：2016-10-01 00:00:00
abstract：BACKGROUND:Urine excreted by the body has a variable composition in different physiological and pathological conditions. The cells that come from the renal pelvis, ureters, bladder, and urethra are carried by the urine, and therefore, they can be observed in fresh samples and in smears with Giemsa and Papanicolaou stai...
journal_title：Journal of cytology
pub_type： 杂志文章
doi：10.4103/0970-9371.130666
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND:Image-guided fine-needle aspiration cytology (FNAC) serves as first-line diagnostic modalities for the assessment of mural thickening of the gallbladder (GB). AIM:The main objective of the present study was to correlate the diagnostic accuracy of preoperative image-guided FNAC of the thickened GB wall based...
journal_title：Journal of cytology
pub_type： 杂志文章
doi：10.4103/0970-9371.171231
更新日期：2015-10-01 00:00:00
abstract：BACKGROUND:It has been shown that cigarette smoking as well as diabetes mellitus can produce cytomorphometric alterations in oral epithelial cells with the significant increase in the nuclear area (NA) and significant decrease in the cytoplasmic/nuclear ratio in comparison to healthy control. However, the synergistic e...
journal_title：Journal of cytology
pub_type： 杂志文章
doi：10.4103/0970-9371.112653
更新日期：2013-04-01 00:00:00
abstract：BACKGROUND:Micronuclei in exfoliated oral epithelial cells have been shown in some studies to correlate with severity of this genotoxic damage. This severity can be measured in terms of grading of the lesions. AIM:To correlate frequency of micronuclei (MN) in oral exfoliated cells in clinically diagnosed cases of oral...
journal_title：Journal of cytology
pub_type： 杂志文章
doi：10.4103/0970-9371.76941
更新日期：2011-01-01 00:00:00
abstract：:In this paper, we have described fine needle aspiration cytology (FNAC) of a rare case of dermal cylindroma. A 40-year-old female presented with a lateral mid-cervical swelling fixed to the skin. FNAC smears showed multiple clusters of small, round to oval cells with hyperchromatic nuclei, inconspicuous nucleoli and s...
journal_title：Journal of cytology
pub_type：
doi：10.4103/0970-9371.151137
更新日期：2014-10-01 00:00:00
abstract：:Extra-abdominal desmoid tumors are known as aggressive fibromatosis (AFM). Synchronous and metachronous multicentric aggressive fibromatosis are rare lesions and pose dilemma in diagnosis and management. A rare and interesting case of recurrent multicentric, synchronous AFM is presented which to the best of our knowle...
journal_title：Journal of cytology
pub_type：
doi：10.4103/0970-9371.93227
更新日期：2012-01-01 00:00:00
abstract：:Primary splenic angiosarcoma is a rare malignant vascular neoplasm of mesenchymal origin. The tumor is highly aggressive and has a high metastatic potential. It is usually diagnosed on histopathological examination of splenectomy specimen. Only few cases of angiosarcoma diagnosed by fine-needle aspiration (FNA) cytolo...
journal_title：Journal of cytology
pub_type：
doi：10.4103/JOC.JOC_148_16
更新日期：2018-04-01 00:00:00
abstract：BACKGROUND:The cytological examinations of serous effusions have been well-accepted, and a positive diagnosis is often considered as a definitive diagnosis. It helps in staging, prognosis and management of the patients in malignancies and also gives information about various inflammatory and non-inflammatory lesions. D...
journal_title：Journal of cytology
pub_type： 杂志文章
doi：10.4103/0970-9371.93210
更新日期：2012-01-01 00:00:00
abstract：:Prostatic adenocarcinoma (PA) is a common visceral malignancy of elderly men. Cutaneous metastasis of PA is rare. The incidence is <1%. A 55-year-old man presented with urinary symptoms and multiple cutaneous nodules around suprapubic region, inner aspect of both thighs and scrotum. Fine-needle aspiration cytology (FN...
journal_title：Journal of cytology
pub_type：
doi：10.4103/0970-9371.160568
更新日期：2015-04-01 00:00:00
abstract：:Hepatoblastoma (HBL) is a rare primary malignant liver tumor affecting mainly pediatric patients in the age group 6 months to 3 years. Presentation of HBL in the neonatal period is rare. HBL can be diagnosed on cytology along with subtyping. Estimation of serum alpha-fetoprotein (AFP) is essential as a tumor marker. F...
journal_title：Journal of cytology
pub_type：
doi：10.4103/0970-9371.103945
更新日期：2012-10-01 00:00:00
abstract：:[This corrects the article on p. 153 in vol. 32, PMID: 26729974.]. ...
journal_title：Journal of cytology
pub_type： 已发布勘误
doi：10.4103/0970-9371.175533
更新日期：2016-01-01 00:00:00
