Abstract:
AIMS:A therapeutic vaccine based on monocyte-derived dendritic cells (MDDCs) has been shown to represent a promising strategy for the treatment of cancer and viral infections. Here, we characterized the MDDCs used as an immunogen in a clinical trial for an anti-HIV-1 therapeutic vaccine. PATIENTS & METHODS:Monocytes obtained from 17 HIV-infected individuals were differentiated into MDDCs and, after loading with autologous HIV, the cells were characterized concerning surface molecule expression, migratory and phagocytosis capacity, cytokine production and the induction of an effective cell-mediated immune response. RESULTS:The MDDCs were able to induce antigen-specific responses in autologous CD4+ and CD8+ T lymphocytes. CONCLUSIONS:Despite a large interindividual variability, the results suggested that MDDCs present the potential to promote immune responses in vaccinated patients.
journal_name
Immunotherapyjournal_title
Immunotherapyauthors
da Silva LT,da Silva WC,de Almeida A,da Silva Reis D,Santillo BT,Rigato PO,da Silva Duarte AJ,Oshiro TMdoi
10.2217/imt-2017-0165subject
Has Abstractpub_date
2018-08-01 00:00:00pages
871-885issue
10eissn
1750-743Xissn
1750-7448journal_volume
10pub_type
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