Rare transformation to double hit lymphoma in Waldenstrom's macroglobulinemia.

Abstract:

:Waldenström macroglobulinemia (WM) is a lymphoproliferative lymphoma that is characterized by monoclonal immunoglobulin M (IgM) protein and bone marrow infiltration. Its incidence is rare and rarer still is its ability to transform to a B-cell lymphoma, particularly the aggressive diffuse large B-cell lymphoma, which bodes a poor prognosis. When transformation includes mutations of MYC, BCL-2 and/or BCL-6, it is known as a 'double hit' or 'triple hit' lymphoma respectively. This paper presents a rare case of WM with mutations positive for MYC and BCL2, making it a case of double hit B-cell lymphoplasmacytic lymphoma with plasmatic differentiation without morphological transformation to aggressive histology like DLBCL. The paper also broadens to include discussions on current topics in the classification, diagnosis, possible causes of transformation, and treatment of WM, including transformation to double hit lymphoma. The significance of this case lies in that the presence of double hit lymphoma-like genetic mutations in WM have not been previously described in the literature and potentially such changes are harbinger of extra-nodal presentation, aggressive growth, and possibly poor prognosis, if data from other double-hit lymphoma are extrapolated.

journal_name

Immunotherapy

journal_title

Immunotherapy

authors

Okolo ON,Johnson AC,Yun S,Arnold SJ,Anwer F

doi

10.2217/imt-2017-0027

subject

Has Abstract

pub_date

2017-08-01 00:00:00

pages

709-714

issue

9

eissn

1750-743X

issn

1750-7448

journal_volume

9

pub_type

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