Abstract:
:Heat-shock proteins (HSPs) have been involved in different functions including chaperone activity, protein folding, apoptosis, autophagy and immunity. The HSP families have powerful effects on the stimulation of innate immune responses through Toll-like receptors and scavenger receptors. Moreover, HSP-mediated phagocytosis directly enhances the processing and presentation of internalized antigens via the endocytic pathway in adaptive immune system. These properties of HSPs have been used for development of prophylactic and therapeutic vaccines against infectious and noninfectious diseases. Several studies also demonstrated the relationship between HSPs and drug resistance as well as their use as a novel biomarker for detecting tumors in patients. The present review describes different roles of HSPs in biology and medicine especially biochemical and immunological aspects.
journal_name
Immunotherapyjournal_title
Immunotherapyauthors
Milani A,Basirnejad M,Bolhassani Adoi
10.2217/imt-2018-0105subject
Has Abstractpub_date
2019-02-01 00:00:00pages
215-239issue
3eissn
1750-743Xissn
1750-7448journal_volume
11pub_type
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