Abstract:
:Background: Progress in immunotherapy (IT) has shifted treatment paradigms for multiple malignancies. In March 2019, the combination of nab-paclitaxel and atezolizumab was approved by the US FDA for patients with PD-L1 positive metastatic triple-negative breast cancer based on positive results of the Impassion130 trial. Although numerous studies have examined the prognostic role of PD-L1, the value of this test remains controversial. Results: Here, we presented the cases of three heavily pretreated women with metastatic triple-negative breast cancer who exhibited remarkable responses to combined IT and chemotherapy despite undetectable PD-L1. Conclusion: In our opinion, the current FDA-approved assessment for PD-L1 expression is a reasonable tool for deciding whether to start IT. However, because this approach has many limitations, patients with undetectable PD-L1 expression should still be considered for IT.
journal_name
Immunotherapyjournal_title
Immunotherapyauthors
Philipovskiy A,Chambers K,Konstantinidis I,McCallum R,Corral J,Gaur Sdoi
10.2217/imt-2020-0202subject
Has Abstractpub_date
2020-12-01 00:00:00pages
1293-1302issue
18eissn
1750-743Xissn
1750-7448journal_volume
12pub_type
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