Abstract:
:Meningiomas are increasingly appreciated to share similar features with other intra-axial central nervous system neoplasms as well as systemic cancers. Immune checkpoint inhibition has emerged as a promising therapy in a number of cancers, with durable responses of years in a subset of patients. Several lines of evidence support a role for immune-based therapeutic strategies in the management of meningiomas, especially high-grade subtypes. Meningiomas frequently originate juxtaposed to venous sinuses, where an anatomic conduit for lymphatic drainage resides. Multiple populations of immune cells have been observed in meningiomas. PD-1/PD-L1 mediated immunosuppression has been implicated in high-grade meningiomas, with association between PD-L1 expression with negative prognostic outcome. These data point to the promise of future combinatorial therapeutic strategies in meningioma.
journal_name
Immunotherapyjournal_title
Immunotherapyauthors
Bi WL,Wu WW,Santagata S,Reardon DA,Dunn IFdoi
10.2217/imt-2016-0017subject
Has Abstractpub_date
2016-06-01 00:00:00pages
721-31issue
6eissn
1750-743Xissn
1750-7448journal_volume
8pub_type
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