Abstract:
:Lactobacilli are a group of normal microbiota whose immunomodulatory effects have been known for a long time. Recently, they have gained more attention for their direct and indirect effects on cancer cells. Several cell line experiments, animal model studies as well as clinical trials have indicated their inhibitory effects on cancer initiation and progression. Different lactobacilli strains could modulate innate and adoptive immune system. Such effects have been documented in modulation of function of T cells, dendritic cells and macrophages as well as cytokine production. In this review, the various immunomodulatory effects of lactobacilli on tumor cells as well as their direct cytotoxic effects on cancer cells are discussed.
journal_name
Immunotherapyjournal_title
Immunotherapyauthors
Abedin-Do A,Taherian-Esfahani Z,Ghafouri-Fard S,Ghafouri-Fard S,Motevaseli Edoi
10.2217/imt.15.92subject
Has Abstractpub_date
2015-01-01 00:00:00pages
1307-29issue
12eissn
1750-743Xissn
1750-7448journal_volume
7pub_type
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