Abstract:
AIM:Previous studies showed that some patients after the treatment of anti-programmed cell death protein-1 (anti-PD-1) antibodies experienced immune-related diarrhea. In this study, we aim to explore the association between intestinal microbiota and immune-related diarrhea. METHODS:We obtained the fecal samples of 26 advanced lung cancer patients before the first dose of anti-PD-1 antibodies. RESULTS:Eight of 26 patients experienced diarrhea after the treatment of anti-PD-1 antibodies. At the phylum level, our study demonstrated that Bacteroidetes were higher in diarrhea-free (D-F) patients, while Firmicutes were lower. Bacteroides and Parabacteroides belonging to Bacteroidetes phylum and Phascolarctobacterium of Firmicutes phylum were more abundant in D-F patients. Whereas, Veillonella of Proteobacteria phylum was lower in D-F patients. CONCLUSION:Our study highlights that intestinal microbiota variation is correlated with the subsequent development of immune-related diarrhea.
journal_name
Immunotherapyjournal_title
Immunotherapyauthors
Liu T,Xiong Q,Li L,Hu Ydoi
10.2217/imt-2018-0144subject
Has Abstractpub_date
2019-04-01 00:00:00pages
385-396issue
5eissn
1750-743Xissn
1750-7448journal_volume
11pub_type
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