Abstract:
:The dysfunctional immune response that characterizes systemic lupus erythematosus (SLE) associates with an unbalanced production of soluble mediators that are crucial in promoting and sustaining chronic inflammation. The successful use of biologics in several autoimmune diseases has led to studies in SLE aimed at contrasting the proinflammatory responses that contribute to tissue and organ damage in the disease. Several approaches have been developed and tested as potential therapeutic agents in SLE in preclinical studies and in clinical trials. This article provides an overview on antibody-based approaches in SLE that, although preliminary, have the potential to expand the current therapeutic possibilities in the disease.
journal_name
Immunotherapyjournal_title
Immunotherapyauthors
La Cava Adoi
10.2217/imt.10.29subject
Has Abstractpub_date
2010-07-01 00:00:00pages
575-82issue
4eissn
1750-743Xissn
1750-7448journal_volume
2pub_type
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