Abstract:
:Injection of autologous tolerogenic dendritic cells is a promising strategy to diminish the burden of harmful immunosuppression in clinical transplantation. We discuss the immunoregulatory mechanisms triggered by this approach. Tolerogenic dendritic cells have long been associated with decreased antigen-processing capacities. However, different lines of evidence led us to propose that injected autologous dendritic cells may need to process donor antigens from graft passenger leukocytes. It is known that drugs such as calcineurin inhibitors can interfere with antigen processing. Indeed, this issue is of the most importance to rationalize the translation of autologous tolerogenic dendritic cell therapy to the clinic.
journal_name
Immunotherapyjournal_title
Immunotherapyauthors
Hill M,Segovia M,Cuturi MCdoi
10.2217/imt.11.40subject
Has Abstractpub_date
2011-04-01 00:00:00pages
12-4issue
4 Suppleissn
1750-743Xissn
1750-7448journal_volume
3pub_type
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