Abstract:
:Sarcoidois is an inflammatory disease of unknown origin characterized by the abnormal accumulation of noncaseating granulomas at sites of disease activity in multiple organs throughout the body with a predilection for the lungs. Because the exact trigger that leads to disease activity is still under investigation, current treatment options are contingent on the organ or organs affected. Corticosteroids are the therapy of choice, but antimalarials and TNF-α antagonists are also commonly prescribed. Recent findings provide evidence for the use of CD20 B-cell-depleting therapy as an alternative method of choice. However, because sarcoidosis is predominantly a T-helper cell-driven disorder, an overwhelming amount of compelling evidence exists for the use of CD4(+) T-cell targeted therapy.
journal_name
Immunotherapyjournal_title
Immunotherapyauthors
Celada LJ,Drake WPdoi
10.2217/imt.14.103subject
Has Abstractpub_date
2015-01-01 00:00:00pages
57-66issue
1eissn
1750-743Xissn
1750-7448journal_volume
7pub_type
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