Abstract:
:There has been a surge in the use of immunotherapy for genitourinary malignancies. Immunotherapy is an established treatment for metastatic renal cell carcinoma and nonmuscle invasive bladder cancer, but its potential for treating prostate cancer (PCa) remains under investigation. Despite reported survival benefits, no published Phase III PCa trials using immunotherapy only as a treatment has demonstrated direct antitumor effects by reducing prostate-specific antigen levels. Subsequently, the thought of combining immunotherapy with other treatment modalities has gained traction as a way to achieving optimal results. Based on data from other malignancies, it is hypothesized that radiotherapy and immunotherapy can act synergistically to improve outcomes. We will discuss the clinical potential of combining immune-based treatments with radiotherapy as a treatment for advanced PCa.
journal_name
Immunotherapyjournal_title
Immunotherapyauthors
Sathianathen NJ,Krishna S,Konety BR,Griffith TSdoi
10.2217/imt-2017-0051subject
Has Abstractpub_date
2017-09-01 00:00:00pages
1005-1018issue
12eissn
1750-743Xissn
1750-7448journal_volume
9pub_type
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