The synergy between ionizing radiation and immunotherapy in the treatment of prostate cancer.

Abstract:

:There has been a surge in the use of immunotherapy for genitourinary malignancies. Immunotherapy is an established treatment for metastatic renal cell carcinoma and nonmuscle invasive bladder cancer, but its potential for treating prostate cancer (PCa) remains under investigation. Despite reported survival benefits, no published Phase III PCa trials using immunotherapy only as a treatment has demonstrated direct antitumor effects by reducing prostate-specific antigen levels. Subsequently, the thought of combining immunotherapy with other treatment modalities has gained traction as a way to achieving optimal results. Based on data from other malignancies, it is hypothesized that radiotherapy and immunotherapy can act synergistically to improve outcomes. We will discuss the clinical potential of combining immune-based treatments with radiotherapy as a treatment for advanced PCa.

journal_name

Immunotherapy

journal_title

Immunotherapy

authors

Sathianathen NJ,Krishna S,Konety BR,Griffith TS

doi

10.2217/imt-2017-0051

subject

Has Abstract

pub_date

2017-09-01 00:00:00

pages

1005-1018

issue

12

eissn

1750-743X

issn

1750-7448

journal_volume

9

pub_type

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