Abstract:
:Programmed cell death-1 protein (PD-1) is an immune checkpoint that has gained popularity in the treatment of several advanced cancers. Inhibiting this checkpoint is known to enhance immune response, but is also known to diminish immune tolerance and to increase autoimmune toxicity. We discuss a case of rapid onset fulminant Type 1 diabetes induced by treatment with anti-programmed cell death-1 monoclonal antibody, nivolumab, in a patient with late-stage non-small-cell lung adenocarcinoma. The patient had no history of previous diabetes but did reveal a high-risk genotype for Type 1 diabetes development (DR3-DQ2; DR4-DQ8). This finding supports that acute Type 1 diabetes can be an important adverse effect of immunotherapies targeting T-cell activation regulation. Because of the severity of this adverse effect, physicians should be aware of it, and studies directed to the detection of new biomarkers for early risk stratification (e.g., HLA) should be sought.
journal_name
Immunotherapyjournal_title
Immunotherapyauthors
Araújo M,Ligeiro D,Costa L,Marques F,Trindade H,Correia JM,Fonseca Cdoi
10.2217/imt-2017-0020subject
Has Abstractpub_date
2017-06-01 00:00:00pages
531-535issue
7eissn
1750-743Xissn
1750-7448journal_volume
9pub_type
杂志文章相关文献
Immunotherapy文献大全abstract::Aim: To assess the safety and effectiveness of an allergen immunotherapy (AIT) with a microcrystalline tyrosine-associated mite allergoid in real-world patients with allergic rhinitis (AR). Materials & methods: Retrospective, multicenter study assessing the safety of AIT in patients aged 5 to 65 years with AR, with or...
journal_title:Immunotherapy
pub_type: 杂志文章
doi:10.2217/imt-2020-0194
更新日期:2020-09-01 00:00:00
abstract:AIMS:A therapeutic vaccine based on monocyte-derived dendritic cells (MDDCs) has been shown to represent a promising strategy for the treatment of cancer and viral infections. Here, we characterized the MDDCs used as an immunogen in a clinical trial for an anti-HIV-1 therapeutic vaccine. PATIENTS & METHODS:Monocytes o...
journal_title:Immunotherapy
pub_type: 杂志文章
doi:10.2217/imt-2017-0165
更新日期:2018-08-01 00:00:00
abstract::Evaluation of: Turksma AW, Bontkes HJ, Ruizendaal JJ et al. Exploring dendritic cell based vaccines targeting survivin for the treatment of head and neck cancer patients. J. Transl. Med. 11, 152-165 (2013). Survivin has been identified to be an inhibitor of apoptosis and is highly expressed in many cancers. A number o...
journal_title:Immunotherapy
pub_type: 评论,杂志文章
doi:10.2217/imt.13.120
更新日期:2013-11-01 00:00:00
abstract::Background: CD19-targeted chimeric antigen receptor (CAR) T-cell therapy has emerged as a powerful immunotherapy in relapsed or refractory B-cell acute lymphoblastic leukemia. The changes in extramedullary (EM) disease in pediatric relapsed or refractory B-cell acute lymphoblastic leukemia after CAR T-cell therapy hav...
journal_title:Immunotherapy
pub_type: 杂志文章
doi:10.2217/imt-2020-0188
更新日期:2021-01-01 00:00:00
abstract::Systemic lupus erythematosus is a systemic autoimmune disease characterized by the presence of myriad autoantibodies, some with pathogenic potential, and diverse clinical manifestations. Involvement of the kidney is a major cause of morbidity and mortality in human lupus patients and in murine models of the disease. I...
journal_title:Immunotherapy
pub_type: 杂志文章
doi:10.2217/imt.12.20
更新日期:2012-04-01 00:00:00
abstract::FOCIS goes South: Advances in Translational and Clinical Immunology was the first Federation of Clinical Immunology Societies (FOCIS) ( www.focisnet.org ) meeting held in Latin America (May 15-17, 2017, Santiago de Chile, Chile). The meeting was organized as a 3-day workshop and was fostered by the Millennium Institut...
journal_title:Immunotherapy
pub_type:
doi:10.2217/imt-2017-0079
更新日期:2017-09-01 00:00:00
abstract::Cancer-testis (CT) antigens are tumor-associated antigens attracting immunologists for their possible application in the immunotherapy of cancer. Several clinical trials have assessed their therapeutic potentials in cancer patients. Breast cancers, especially triple-negative cancers are among those with significant ex...
journal_title:Immunotherapy
pub_type: 杂志文章,评审
doi:10.2217/imt.13.165
更新日期:2014-01-01 00:00:00
abstract::Melanoma antigen family A, 3 (MAGE-A3) is a cancer-testis antigen whose expression has been demonstrated in a wide array of malignancies including melanoma, brain, breast, lung and ovarian cancer. In addition, its ability to elicit spontaneous humoral and cellular immune responses has been shown in cancer patients. As...
journal_title:Immunotherapy
pub_type: 杂志文章,评审
doi:10.2217/imt.15.29
更新日期:2015-01-01 00:00:00
abstract::Brain tumors present unique therapeutic challenges and they include glioblastoma (GBM) and metastases from cancers of other organs. Current treatment options are limited and include surgical resection, radiation therapy, laser interstitial thermal therapy and chemotherapy. Although much research has been done on the d...
journal_title:Immunotherapy
pub_type: 杂志文章
doi:10.2217/imt-2019-0023
更新日期:2019-10-01 00:00:00
abstract::Tumor immune evasion is one of the hallmarks of cancer, and expression of the B7 family of immune checkpoints (PD-L1, PD-L2, B7-H3, B7x and HHLA2) is one mechanism of immune evasion by tumors to suppress T-cell function. Antibodies blocking these interactions of B7-1/B7-2/CTLA-4 and PD-L1/PD-L2/PD-1 have had remarkabl...
journal_title:Immunotherapy
pub_type: 杂志文章,评审
doi:10.2217/imt-2016-0001
更新日期:2016-06-01 00:00:00
abstract::The insight gained recently on the differentiation of naive CD4 T cells challenges the dogma that expression of canonical transcription factors and production of signature cytokines portray a commitment to a specific lineage and a point of no return. For almost two decades now, the belief has been that naive CD4 T cel...
journal_title:Immunotherapy
pub_type: 评论,杂志文章
doi:10.2217/1750743X.1.1.27
更新日期:2009-01-01 00:00:00
abstract::Aim: To analyze the efficacy of checkpoint inhibitors in soft tissue sarcoma. Materials & methods: We retrospectively reviewed patients with advanced soft tissue sarcoma treated with ipilimumab and nivolumab. All patients who received at least one cycle were included. Results: One patient had a complete response and f...
journal_title:Immunotherapy
pub_type: 杂志文章
doi:10.2217/imt-2020-0155
更新日期:2020-12-01 00:00:00
abstract::Activation of a patient's immune system offers an attractive approach to prevent and treat hepatocellular carcinoma (HCC). However, the antitumor efficacy of current HCC vaccines was weak owing to insufficient immune activation of targeting self/tumor antigens. We recently found that epitope-optimized α-fetoprotein ef...
journal_title:Immunotherapy
pub_type: 杂志文章,评审
doi:10.2217/imt.14.46
更新日期:2014-01-01 00:00:00
abstract::Developing effective vaccines against Neisseria meningitidis serogroup B has been challenging for several reasons, including the fact that the capsular polysaccharide of N. meningitidis serogroup B is a poor antigen. Therefore, studies have focused on developing vaccines that target capsular protein meningococcal anti...
journal_title:Immunotherapy
pub_type: 杂志文章,评审
doi:10.2217/imt.14.11
更新日期:2014-01-01 00:00:00
abstract::The prognosis of high-risk neuroblastoma (NB) is still poor, in spite of aggressive multimodal treatment. Recently, adjuvant immunotherapy with anti-GD2 antibodies combined with IL-2 or GM-CSF has been shown to improve survival. Several other immunotherapy strategies proved efficacy in preclinical models of NB, includ...
journal_title:Immunotherapy
pub_type: 杂志文章,评审
doi:10.2217/imt.14.117
更新日期:2015-01-01 00:00:00
abstract:AIM:A 1-year follow-up study comparing the safety and tolerability of the dosing schedules, satisfaction and effectiveness of a novel microcrystalline tyrosine-adsorbed mite (Dermatophagoides pteronyssinus)-allergoid subcutaneous immunotherapy (Acarovac Plus™) in 30 adult patients (18-65 years) with allergic rhinitis a...
journal_title:Immunotherapy
pub_type: 杂志文章
doi:10.2217/imt-2016-0068
更新日期:2016-10-01 00:00:00
abstract::Oncogenic signaling pathways have emerged as key targets for the development of small-molecule inhibitors, with several protein kinase inhibitors already in clinical use for cancer patients. In addition to their role in tumorigenesis, many of the molecules and signaling pathways targeted by these inhibitors are also i...
journal_title:Immunotherapy
pub_type: 杂志文章,评审
doi:10.2217/imt.10.99
更新日期:2011-02-01 00:00:00
abstract::Mycobacterium tuberculosis was one of the first human pathogens to be identified as the cause of a specific disease--TB. TB was also one of the first specific diseases for which immunotherapy was attempted. In more than a century since, multiple different immunotherapies have been attempted, alongside vaccination and ...
journal_title:Immunotherapy
pub_type: 杂志文章,评审
doi:10.2217/imt.12.52
更新日期:2012-06-01 00:00:00
abstract::Viral hemorrhagic fevers (VHFs) often cause high mortality with high infectivity, multiorgan failure, shock and hemorrhagic diathesis. Fibroblastic reticular cells (FRCs) within secondary lymphoid organs provide a supporting scaffold to T-lymphocyte areas. These cells regulate the movement of various immune cells and ...
journal_title:Immunotherapy
pub_type: 杂志文章
doi:10.2217/1750743X.1.2.187
更新日期:2009-03-01 00:00:00
abstract::In spite of the considerable successes that have been achieved in the treatment of chronic myeloid leukemia (CML), cure for the disease can only be obtained by the present means in a rather small minority of patients. During the past decade, considerable progress has been made in the understanding of the immunology of...
journal_title:Immunotherapy
pub_type: 杂志文章,评审
doi:10.2217/imt.10.2
更新日期:2010-03-01 00:00:00
abstract::In recent years, there have been reports of immunotherapy inducing objective clinical responses in limited numbers of cancer patients. More frequently, however, clinical responses are not observed. Understanding the immunological mechanisms underlying successful immunotherapy are crucial if the field is to move forwar...
journal_title:Immunotherapy
pub_type: 评论,杂志文章
doi:10.2217/imt.11.62
更新日期:2011-06-01 00:00:00
abstract:AIM:We developed a novel approach to efficiently deliver autologous tumor antigens to the cytoplasm of dendritic cells (DC) using yeast cell wall particles (YCWP). MATERIALS AND METHODS:Loading of YCWP, leakage of protein from loaded YCWP and cytoplasmic delivery of YCWP content was assessed using fluorescent-tagged e...
journal_title:Immunotherapy
pub_type: 杂志文章
doi:10.2217/imt-2017-0114
更新日期:2018-04-01 00:00:00
abstract::Following cancer treatment, patients often report behavioral and cognitive changes. Novel cancer immunotherapeutics have the potential to produce sustained cancer survivorship, meaning patients will live longer with the side effects of treatment. Given the role of inflammatory pathways in mediating behavioral and cogn...
journal_title:Immunotherapy
pub_type: 杂志文章,评审
doi:10.2217/imt-2017-0056
更新日期:2017-09-01 00:00:00
abstract::TB is an infectious disease that still has an enormous impact on public health worldwide. With the continuous increasing epidemic of multidrug-resistant TB, new drugs and vaccines are urgently needed. In the last decade there has been a broad advance in the knowledge of innate immunity in TB. Together with the growing...
journal_title:Immunotherapy
pub_type: 杂志文章,评审
doi:10.2217/imt.13.111
更新日期:2013-10-01 00:00:00
abstract::Sarcoidosis is a systemic disease with an incidence of 1 to 40 per 100 000 persons per year. It predominantly affects people in the age of 20 to 40 years old. Disease course varies from mild self-limiting to chronic debilitating and life-threatening disease. Since the cause of sarcoidosis is unknown, curative therapy ...
journal_title:Immunotherapy
pub_type: 杂志文章,评审
doi:10.2217/imt.14.65
更新日期:2014-01-01 00:00:00
abstract::The complex homeostasis of tissues is coordinated by the cytokine network and imbalances in this network may result in chronic immune disorders. Key specific cytokines, such as TNF-alpha, IFN-alpha, IL-4 or VEGF have been demonstrated to be overproduced or abnormally released in the microenvironment of pathologic tiss...
journal_title:Immunotherapy
pub_type: 杂志文章,评审
doi:10.2217/imt.10.16
更新日期:2010-05-01 00:00:00
abstract::Evaluation of: Pesce B, Soto L, Sabugo F et al. Effect of interleukin-6 receptor blockade on the balance between regulatory T cells and T helper type 17 cells in rheumatoid arthritis patients. Clin. Exp. Immunol. 171, 237-242 (2012). Clinical trials of a humanized anti-IL-6 receptor antibody, tocilizumab (TCZ), proved...
journal_title:Immunotherapy
pub_type: 评论,杂志文章
doi:10.2217/imt.13.47
更新日期:2013-07-01 00:00:00
abstract::There has been growing evidence that heat-shock protein (HSP) functions as an endogenous immunomodulator for innate and adaptive immune responses. Since HSPs inherently act as chaperones within cells, passive release (e.g., by cell necrosis) and active release (including release by secretion in the form of an exosome)...
journal_title:Immunotherapy
pub_type: 杂志文章,评审
doi:10.2217/imt.12.75
更新日期:2012-08-01 00:00:00
abstract::Immunotherapy holds a highly promising treatment approach for metastatic melanoma patients. Adoptive cell transfer (ACT) involves the ex vivo expansion of autologous antitumor reactive lymphocytes and their reinfusion into lymphodepleted patients, accompanied by IL-2 administration. ACT with tumor-infiltrating T lymph...
journal_title:Immunotherapy
pub_type: 杂志文章,评审
doi:10.2217/imt.12.143
更新日期:2013-01-01 00:00:00
abstract::Pediatric eosinophilic esophagitis is an inflammatory condition associated with marked eosinophil accumulation in the mucosal tissues of the esophagus. Eosinophils are major proinflammatory cells thought to make a major contribution to allergic diseases that affect the upper and lower airways, skin and GI tract. IL-5 ...
journal_title:Immunotherapy
pub_type: 杂志文章
doi:10.2217/imt.10.41
更新日期:2010-07-01 00:00:00