Abstract:
:Rheumatoid arthritis (RA) is a chronic inflammatory disease in which persistent inflammation of synovial tissue results in a progressive functional decline of the joint and premature mortality. TNF inhibitors were the first biological disease-modifying antirheumatic drugs (DMARDs) used to treat RA. Since then, new biological drugs have emerged, such as inhibitors of IL-1, IL-6 and others, with different mechanisms of action that include the depletion of B cells and the inhibition of T-cell costimulation. Recently, RA treatments have incorporated the use of synthetic DMARDs. This review describes the molecular aspects of the mechanisms of action of biological and synthetic DMARDs, discusses the adverse effects and limitations of established therapies and analyses the alternative approaches to RA treatment.
journal_name
Immunotherapyjournal_title
Immunotherapyauthors
García-Hernández MH,González-Amaro R,Portales-Pérez DPdoi
10.2217/imt.14.26subject
Has Abstractpub_date
2014-01-01 00:00:00pages
623-36issue
5eissn
1750-743Xissn
1750-7448journal_volume
6pub_type
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