Abstract:
:Chronic rhinosinusitis with nasal polyposis (CRSwNP) imparts a significant healthcare challenge, resulting in diminished quality of life for patients and high costs with resource utilization for disease management. Understanding of CRSwNP pathophysiology has progressively evolved and the identification of various inflammatory biomarkers has led to the development of monoclonal antibodies that target the underlying mechanisms of inflammation. Dupilumab, which targets IL-4 and IL-13 signaling, serves as a novel agent for CRSwNP treatment. Three clinical trials, NCT01920893, SINUS-24 and SINUS-52, have shown that dupilumab improves both subjective patient-reported outcomes and objective physician-evaluated metrics for CRSwNP. The favorable findings have resulted in approval by the US FDA in June 2019 as the first biologic therapy for CRSwNP.
journal_name
Immunotherapyjournal_title
Immunotherapyauthors
Boyle JV,Lam K,Han JKdoi
10.2217/imt-2019-0191subject
Has Abstractpub_date
2020-02-01 00:00:00pages
111-121issue
2eissn
1750-743Xissn
1750-7448journal_volume
12pub_type
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