Dupilumab in the treatment of chronic rhinosinusitis with nasal polyposis.

Abstract:

:Chronic rhinosinusitis with nasal polyposis (CRSwNP) imparts a significant healthcare challenge, resulting in diminished quality of life for patients and high costs with resource utilization for disease management. Understanding of CRSwNP pathophysiology has progressively evolved and the identification of various inflammatory biomarkers has led to the development of monoclonal antibodies that target the underlying mechanisms of inflammation. Dupilumab, which targets IL-4 and IL-13 signaling, serves as a novel agent for CRSwNP treatment. Three clinical trials, NCT01920893, SINUS-24 and SINUS-52, have shown that dupilumab improves both subjective patient-reported outcomes and objective physician-evaluated metrics for CRSwNP. The favorable findings have resulted in approval by the US FDA in June 2019 as the first biologic therapy for CRSwNP.

journal_name

Immunotherapy

journal_title

Immunotherapy

authors

Boyle JV,Lam K,Han JK

doi

10.2217/imt-2019-0191

subject

Has Abstract

pub_date

2020-02-01 00:00:00

pages

111-121

issue

2

eissn

1750-743X

issn

1750-7448

journal_volume

12

pub_type

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