Dupilumab in the treatment of chronic rhinosinusitis with nasal polyposis.


:Chronic rhinosinusitis with nasal polyposis (CRSwNP) imparts a significant healthcare challenge, resulting in diminished quality of life for patients and high costs with resource utilization for disease management. Understanding of CRSwNP pathophysiology has progressively evolved and the identification of various inflammatory biomarkers has led to the development of monoclonal antibodies that target the underlying mechanisms of inflammation. Dupilumab, which targets IL-4 and IL-13 signaling, serves as a novel agent for CRSwNP treatment. Three clinical trials, NCT01920893, SINUS-24 and SINUS-52, have shown that dupilumab improves both subjective patient-reported outcomes and objective physician-evaluated metrics for CRSwNP. The favorable findings have resulted in approval by the US FDA in June 2019 as the first biologic therapy for CRSwNP.






Boyle JV,Lam K,Han JK




Has Abstract


2020-02-01 00:00:00












  • Kinoids: a family of immunogens for active anticytokine immunotherapy applied to autoimmune diseases and cancer.

    abstract::The complex homeostasis of tissues is coordinated by the cytokine network and imbalances in this network may result in chronic immune disorders. Key specific cytokines, such as TNF-alpha, IFN-alpha, IL-4 or VEGF have been demonstrated to be overproduced or abnormally released in the microenvironment of pathologic tiss...


    pub_type: 杂志文章,评审


    authors: Bizzini B,Drouet B,Zagury D,Abitbol M,Burny A,Boissier MC

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  • The role of the microbiome in childhood asthma.

    abstract::It is now well established that the healthy bronchial tree contains a microbiome distinct from that of the upper respiratory tract and that the lung microbiome may be dysregulated in individuals with a chronic respiratory disease, such as asthma. In addition, after birth, gut microbes interact with the host tissue, es...


    pub_type: 杂志文章,评审


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  • Intraperitoneal radioimmunotherapy: Auger electron emitters for solid tumors.

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    pub_type: 评论,杂志文章


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  • The split personality of NKT cells in malignancy, autoimmune and allergic disorders.

    abstract::NKT cells are a heterogeneous subset of specialized, self-reactive T cells, with innate and adaptive immune properties, which allow them to bridge innate and adaptive immunity and profoundly influence autoimmune and malignant disease outcomes. NKT cells mediate these activities through their ability to rapidly express...


    pub_type: 杂志文章,评审


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  • Vaccinia virus, a promising new therapeutic agent for pancreatic cancer.

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    pub_type: 杂志文章,评审


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  • Immunotherapy of chronic myeloid leukemia: present state and future prospects.

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    pub_type: 杂志文章,评审


    authors: Vonka V

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  • Tumor lysate particle loaded dendritic cell vaccine: preclinical testing of a novel personalized cancer vaccine.

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    pub_type: 杂志文章


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    pub_type: 杂志文章,评审


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  • Reslizumab for pediatric eosinophilic esophagitis.

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    pub_type: 杂志文章


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  • Rare transformation to double hit lymphoma in Waldenstrom's macroglobulinemia.

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    pub_type: 杂志文章


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  • Effect of inhaled inactivated Mycobacterium phlei in children with moderate asthma.

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    pub_type: 杂志文章,随机对照试验


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    pub_type: 杂志文章,评审


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  • Jacalin regulates IgA production by peripheral blood mononuclear cells.

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    pub_type: 杂志文章


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  • First-line treatment of advanced/metastatic melanoma with anti-PD-1 antibodies: multicenter experience in Poland.

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    pub_type: 杂志文章


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  • Preventing stem cell transplantation-associated viral infections using T-cell therapy.

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    pub_type: 杂志文章,评审


    authors: Tzannou I,Leen AM

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  • Genetic modification of natural killer cells for adoptive cellular immunotherapy.

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    pub_type: 杂志文章,评审


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  • γδ T cells as a potential tool in colon cancer immunotherapy.

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    pub_type: 杂志文章,评审


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  • Immune modulation by apoptotic dental pulp stem cells in vivo.

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    pub_type: 杂志文章


    authors: Laing AG,Riffo-Vasquez Y,Sharif-Paghaleh E,Lombardi G,Sharpe PT

    更新日期:2018-03-01 00:00:00

  • Efficacy and tolerability of a house dust mite allergoid in allergic bronchial asthma: a randomized dose-ranging trial.

    abstract:AIM:This multicenter randomized placebo-controlled double-blind clinical trial investigated which maintenance dose shows the optimal benefit-risk ratio for subcutaneous immunotherapy with a Dermatophagoides pteronyssinus allergoid preparation. OBJECTIVE:To evaluate four maintenance doses of the allergoid preparation v...


    pub_type: 杂志文章,多中心研究,随机对照试验


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  • Immunomodulatory effects of Lactobacillus strains: emphasis on their effects on cancer cells.

    abstract::Lactobacilli are a group of normal microbiota whose immunomodulatory effects have been known for a long time. Recently, they have gained more attention for their direct and indirect effects on cancer cells. Several cell line experiments, animal model studies as well as clinical trials have indicated their inhibitory e...


    pub_type: 杂志文章,评审


    authors: Abedin-Do A,Taherian-Esfahani Z,Ghafouri-Fard S,Ghafouri-Fard S,Motevaseli E

    更新日期:2015-01-01 00:00:00

  • Anti-CD20 monoclonal antibodies in chronic lymphocytic leukemia: from uncertainties to promises.

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    pub_type: 杂志文章,评审


    authors: Bagacean C,Zdrenghea M,Tempescul A,Cristea V,Renaudineau Y

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  • JAK2 inhibition in murine systemic lupus erythematosus.

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    pub_type: 杂志文章


    authors: Tagoe C,Putterman C

    更新日期:2012-04-01 00:00:00

  • T-regulatory/T-helper 17: promiscuous signals and fear of commitment.

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    pub_type: 评论,杂志文章


    authors: Tartar DM,van Morlan AM,Zaghouani H

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  • Fibroblastic reticular cell infection by hemorrhagic fever viruses.

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    pub_type: 杂志文章


    authors: Steele KE,Anderson AO,Mohamadzadeh M

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  • Front-line daratumumab-VTd versus standard-of-care in ASCT-eligible multiple myeloma: matching-adjusted indirect comparison.

    abstract::Aim: To compare daratumumab plus standard-of-care (SoC; bortezomib/thalidomide/dexamethasone [VTd]) and VTd alone with other SoC for transplant-eligible newly diagnosed multiple myeloma. Patients & methods: We conducted an unanchored matching-adjusted indirect comparison of progression-free and overall survival (PFS/O...


    pub_type: 杂志文章


    authors: Moreau P,Hebraud B,Facon T,Leleu X,Hulin C,Hashim M,Hu Y,Caillot D,Benboubker L,Zweegman S,Merz M,Weisel K,Salwender H,Mai EK,Goldschmidt H,Bertsch U,Vanquickelberghe V,Kampfenkel T,Boer C,Krotneva S,Proskorovsky

    更新日期:2021-02-01 00:00:00

  • Designing two-in-one antibodies.

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    pub_type: 评论,杂志文章


    authors: Valladares IG,Espinoza LR

    更新日期:2009-09-01 00:00:00

  • Depletion of Tregs in vivo: a promising approach to enhance antitumor immunity without autoimmunity.

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    pub_type: 评论,杂志文章


    authors: Morita R,Hirohashi Y,Sato N

    更新日期:2012-11-01 00:00:00

  • Engineering α-fetoprotein-based gene vaccines to prevent and treat hepatocellular carcinoma: review and future prospects.

    abstract::Activation of a patient's immune system offers an attractive approach to prevent and treat hepatocellular carcinoma (HCC). However, the antitumor efficacy of current HCC vaccines was weak owing to insufficient immune activation of targeting self/tumor antigens. We recently found that epitope-optimized α-fetoprotein ef...


    pub_type: 杂志文章,评审


    authors: He Y,Hong Y,Mizejewski GJ

    更新日期:2014-01-01 00:00:00

  • Rate of cancer progression as a predictive marker of efficacy of immunotherapy; an analysis in metastatic non-small-cell lung cancer.

    abstract::Aim: To explore the value of rate of cancer progression (ROP) prior to starting PD-1 inhibitors as a predictive and prognostic biomarker. Materials & methods: Retrospective data of patients with metastatic non-small-cell lung cancer treated with second-line PD-1 inhibitors were collected. Patients were divided into tw...


    pub_type: 临床试验,杂志文章,多中心研究


    authors: Prasanna T,Arasaratnam M,Boyer M,McNeil C,Barnet MB,Asher R,Hui R,Nagrial A,Kao S

    更新日期:2019-06-01 00:00:00

  • Anti-TNF therapeutics for the treatment of sarcoidosis.

    abstract::Sarcoidosis is a systemic disease with an incidence of 1 to 40 per 100 000 persons per year. It predominantly affects people in the age of 20 to 40 years old. Disease course varies from mild self-limiting to chronic debilitating and life-threatening disease. Since the cause of sarcoidosis is unknown, curative therapy ...


    pub_type: 杂志文章,评审


    authors: Crommelin HA,Vorselaars AD,van Moorsel CH,Korenromp IH,Deneer VH,Grutters JC

    更新日期:2014-01-01 00:00:00