Abstract:
AIM:It is becoming apparent that emphysema is partly driven by self-reactive T cells inducing inflammatory damage. Thus, T cells become targets for therapy similar to other autoimmune diseases. Costimulatory blockade therapy targets disease-specific T cells, rendering them ineffective by blocking a necessary costimulatory event on the T-cell surface. This therapy is tested here in mouse emphysema. MATERIALS & METHODS:Peptides representing contact domains of counter receptors LFA-1 and ICAM-1 were used as blockade therapy in elastase-induced emphysema. RESULTS:When administered during the first week after disease induction, blockade prevented lung destruction, reduced leukocyte infiltration and inhibited the decrease in T-cell CD4:CD8 ratio, also common in human emphysema. CONCLUSION:Costimulatory blockade therapy can affect the progress of emphysema.
journal_name
Immunotherapyjournal_title
Immunotherapyauthors
Newton AH,Danahy DB,Chan MA,Benedict SHdoi
10.2217/imt.15.31subject
Has Abstractpub_date
2015-01-01 00:00:00pages
621-9issue
6eissn
1750-743Xissn
1750-7448journal_volume
7pub_type
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