Abstract:
:The poor prognosis of pancreatic cancer patients signifies a need for radically new therapeutic strategies. Tumor-targeted oncolytic viruses have emerged as attractive therapeutic candidates for cancer treatment due to their inherent ability to specifically target and lyse tumor cells as well as induce antitumor effects by multiple action mechanisms. Vaccinia virus has several inherent features that make it particularly suitable for use as an oncolytic agent. In this review, we will discuss the potential of vaccinia virus in the management of pancreatic cancer in light of our increased understanding of cellular and immunological mechanisms involved in the disease process as well as our extending knowledge in the biology of vaccinia virus.
journal_name
Immunotherapyjournal_title
Immunotherapyauthors
Al Yaghchi C,Zhang Z,Alusi G,Lemoine NR,Wang Ydoi
10.2217/imt.15.90subject
Has Abstractpub_date
2015-01-01 00:00:00pages
1249-58issue
12eissn
1750-743Xissn
1750-7448journal_volume
7pub_type
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