Abstract:
:After the first wave of the tsunami of immune checkpoint inhibitors, 2016 was marked by the second wave, revealed by numerous US FDA approvals, publications and abstracts in relation with these drugs in different cancers and settings. First, we reported all new indications of anti-CTLA4, anti-programmed cell death protein 1 and anti-PDL1 approved by the FDA, the positive clinical trials published and the abstracts reported at important scientific meetings during 2016. Then, we highlighted the updates on debatable issues related to checkpoint inhibitors, since the first wave published in a previous issue. We focused on the predictive biomarkers, combination therapies, tumor response patterns and efficacy in particular settings and the side effect management. Finally, the impact of checkpoint inhibitors development on the care management of cancer centers will be discussed.
journal_name
Immunotherapyjournal_title
Immunotherapyauthors
Kourie HR,Awada G,Awada Adoi
10.2217/imt-2017-0029subject
Has Abstractpub_date
2017-06-01 00:00:00pages
647-657issue
8eissn
1750-743Xissn
1750-7448journal_volume
9pub_type
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