Abstract:
:Since the discovery of the CD40-CD154 costimulatory pathway and its critical role in the adaptive immune response, there has been considerable interest in therapeutically targeting this interaction with monoclonal antibodies in transplantation. Unfortunately, initial promise in animal models gave way to disappointment in clinical trials following a number of thromboembolic complications. However, recent mechanistic studies have identified the mechanism of these adverse events, as well as detailed a myriad of interactions between CD40 and CD154 on a wide variety of immune cell types and the critical role of this pathway in generating both humoral and cell-mediated alloreactive responses. This has led to resurgence in interest and the potential resurrection of anti-CD154 and anti-CD40 antibodies as clinically viable therapeutic options.
journal_name
Immunotherapyjournal_title
Immunotherapyauthors
Pinelli DF,Ford MLdoi
10.2217/imt.15.1subject
Has Abstractpub_date
2015-01-01 00:00:00pages
399-410issue
4eissn
1750-743Xissn
1750-7448journal_volume
7pub_type
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