Abstract:
:Aim: To investigate whether and how CD4+ T cells contribute to ILC2 activation during respiratory syncytial virus (RSV) infection. Methods: The methods of flow cytometry, quantitative PCR and ELISA were used in the present study. Results: Depletion of CD4+ T cells diminished the numbers of lung ILC2s as well as their ability to produce type 2 cytokines. CD4+ T cell-mediated ILC2 activation is related to IL-2. The main cellular source of IL-2 was CD4+ T cells. Depletion of CD4+ T cells decreased IL-2 levels in the lungs of RSV-infected mice. IL-2 can directly stimulate ILC2 proliferation and promote ILC2s to produce cytokines. Treatment of mice with neutralizing anti-IL-2 monoclonal antibodies diminished ILC2 activation. Conclusion: These results suggest that CD4+ T cells contribute to RSV-induced ILC2 activation partly via producing IL-2.
journal_name
Immunotherapyjournal_title
Immunotherapyauthors
Han X,Bai S,Cui Y,Zhu W,Zhao N,Liu Bdoi
10.2217/imt-2019-0084subject
Has Abstractpub_date
2019-10-01 00:00:00pages
1303-1313issue
15eissn
1750-743Xissn
1750-7448journal_volume
11pub_type
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