Abstract:
:Evaluation of: Savoldo B, Ramos CA, Liu E et al. CD28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T cells in lymphoma patients. J. Clin. Invest. 121(5), 1822-1826 (2011). Chimeric antigen receptor (CAR)-T cells are promising antitumor immunotherapies. However, there are limited reports of persistence, tumor-homing and clinical efficacy in cancer patients. Savoldo and colleagues used a novel approach to compare the use of first- and second-generation tumor-specific CAR-T cells in six B-cell lymphoma patients. They provide one of the first comparisons in human subjects and demonstrate the superiority of second-generation CAR-T cells to expand, survive and home to the tumor site.
journal_name
Immunotherapyjournal_title
Immunotherapyauthors
Gandhi M,Jones Kdoi
10.2217/imt.11.135subject
Has Abstractpub_date
2011-12-01 00:00:00pages
1441-3issue
12eissn
1750-743Xissn
1750-7448journal_volume
3pub_type
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