Abstract:
:Cancer-testis (CT) antigens are tumor-associated antigens attracting immunologists for their possible application in the immunotherapy of cancer. Several clinical trials have assessed their therapeutic potentials in cancer patients. Breast cancers, especially triple-negative cancers are among those with significant expression of CT genes. Identification of CT genes with high expression in cancer patients is the prerequisite for any immunotherapeutic approach. CT genes have gained attention not only for immunotherapy of cancer patients, but also for immunoprevention in high-risk individuals. Many CT genes have proved to be immunogenic in breast cancer patients suggesting the basis for the development of polyvalent vaccines.
journal_name
Immunotherapyjournal_title
Immunotherapyauthors
Ghafouri-Fard S,Shamsi R,Seifi-Alan M,Javaheri M,Tabarestani Sdoi
10.2217/imt.13.165subject
Has Abstractpub_date
2014-01-01 00:00:00pages
165-79issue
2eissn
1750-743Xissn
1750-7448journal_volume
6pub_type
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