Abstract:
:In recent years, nanoparticulate-mediated drug delivery research has examined a full spectrum of nanoparticles that can be used in diagnostic and therapeutic cancer applications. A key aspect of this technology is in the potential to specifically target the nanoparticles to diseased cells using a range of molecules, in particular antibodies. Antibody-nanoparticle conjugates have the potential to elicit effective targeting and release of therapeutic targets at the disease site, while minimizing off-target side effects caused by dosing of normal tissues. This article provides an overview of various antibody-conjugated nanoparticle strategies, focusing on the rationale of cell-surface receptors targeted and their potential clinical application.
journal_name
Immunotherapyjournal_title
Immunotherapyauthors
Fay F,Scott CJdoi
10.2217/imt.11.5subject
Has Abstractpub_date
2011-03-01 00:00:00pages
381-94issue
3eissn
1750-743Xissn
1750-7448journal_volume
3pub_type
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