CNS side effects of immune checkpoint inhibitors: preclinical models, genetics and multimodality therapy.

Abstract:

:Following cancer treatment, patients often report behavioral and cognitive changes. Novel cancer immunotherapeutics have the potential to produce sustained cancer survivorship, meaning patients will live longer with the side effects of treatment. Given the role of inflammatory pathways in mediating behavioral and cognitive impairments seen in cancer, we aim in this review to discuss emerging evidence for the contribution of immune checkpoint blockade to exacerbate these CNS effects. We discuss ongoing studies regarding the ability of immune checkpoint inhibitors to reach the brain and how treatment responses to checkpoint inhibitors may be modulated by genetic factors. We further consider the use of preclinical tumor-models to study the role of tumor status in CNS effects of immune checkpoint inhibitors and multimodality therapy.

journal_name

Immunotherapy

journal_title

Immunotherapy

authors

McGinnis GJ,Raber J

doi

10.2217/imt-2017-0056

subject

Has Abstract

pub_date

2017-09-01 00:00:00

pages

929-941

issue

11

eissn

1750-743X

issn

1750-7448

journal_volume

9

pub_type

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