Abstract:
:The era of active immunotherapy has now been successfully ushered into the clinical realm of advanced prostate cancer. The successful clinical trial development and US FDA approval of sipuleucel-T (Provenge®) has revamped the therapeutic paradigm for advanced prostate cancer. Nonetheless, physician and patient education as well as regulatory pathways and manufacturing efficiencies are still required in order to optimize patient care. These topics were covered at the Phacilitate Barcelona Active Immunotherapeutics Forum.
journal_name
Immunotherapyjournal_title
Immunotherapyauthors
Shore NDdoi
10.2217/imt.11.90subject
Has Abstractpub_date
2011-08-01 00:00:00pages
931-2issue
8eissn
1750-743Xissn
1750-7448journal_volume
3pub_type
总体相关文献
Immunotherapy文献大全abstract::FOCIS goes South: Advances in Translational and Clinical Immunology was the first Federation of Clinical Immunology Societies (FOCIS) ( www.focisnet.org ) meeting held in Latin America (May 15-17, 2017, Santiago de Chile, Chile). The meeting was organized as a 3-day workshop and was fostered by the Millennium Institut...
journal_title:Immunotherapy
pub_type:
doi:10.2217/imt-2017-0079
更新日期:2017-09-01 00:00:00
abstract::The human IgG2 monoclonal antibody tremelimumab is an immune checkpoint inhibitor that blocks cytotoxic T lymphocyte-associated antigen-4 (CTLA-4). The therapeutic response of anti-CTLA-4 monoclonal antibodies possess unique kinetics, in that antitumor responses are often observed after initial short-term disease prog...
journal_title:Immunotherapy
pub_type: 杂志文章
doi:10.2217/imt.15.89
更新日期:2016-01-01 00:00:00
abstract::Evaluation of: Boudousq V, Ricaud S, Garambois V et al.: Brief intraperitoneal radioimmunotherapy of small peritoneal carcinomatosis using high activities of noninternalizing (125)I-labeled monoclonal antibodies. J. Nucl. Med. 51, 1748-1755 (2010). Mesothelioma, pseudomyxoma peritonei, ovarian and colon cancers, and s...
journal_title:Immunotherapy
pub_type: 评论,杂志文章
doi:10.2217/imt.11.11
更新日期:2011-04-01 00:00:00
abstract::Tumor-associated macrophages (TAMs), representing most of the leukocyte population in solid tumors, demonstrate great phenotypic heterogeneity and diverse functional capabilities under the influence of the local tumor microenvironment. These anti-inflammatory and protumorigenic macrophages modulate the local microenvi...
journal_title:Immunotherapy
pub_type: 杂志文章,评审
doi:10.2217/imt-2016-0135
更新日期:2017-03-01 00:00:00
abstract::Background: Immunotherapy has revolutionized the treatment of cancer, but this has not come without a cost. Although immune checkpoint inhibitors are less toxic than conventional chemotherapy, they are associated with more frequent autoimmune side effects. Case presentation: We report a case of a patient with metastat...
journal_title:Immunotherapy
pub_type: 杂志文章
doi:10.2217/imt-2020-0053
更新日期:2020-06-01 00:00:00
abstract::Therapeutic vaccination with dendritic cells (DCs) is recognized as an important experimental therapy for the treatment of minimal residual disease in acute myeloid leukemia. Many sources of leukemia-associated antigens and different methods for antigen loading of DCs have been used in an attempt to optimize anti-tumo...
journal_title:Immunotherapy
pub_type: 杂志文章,评审
doi:10.2217/imt.09.85
更新日期:2010-01-01 00:00:00
abstract:AIM:Placenta specific 1 (PLAC1) is a protein rarely expressed in normal cells, except it is important for placental development, with a possible role in the establishment of the mother-fetus interface. The gene is also highly active in a wide variety of cancers and therefore, immunization with PLAC1 peptides could poss...
journal_title:Immunotherapy
pub_type: 杂志文章
doi:10.2217/imt-2017-0019
更新日期:2017-05-01 00:00:00
abstract:AIM:It is becoming apparent that emphysema is partly driven by self-reactive T cells inducing inflammatory damage. Thus, T cells become targets for therapy similar to other autoimmune diseases. Costimulatory blockade therapy targets disease-specific T cells, rendering them ineffective by blocking a necessary costimulat...
journal_title:Immunotherapy
pub_type: 杂志文章
doi:10.2217/imt.15.31
更新日期:2015-01-01 00:00:00
abstract::Aim: Assessment of safety, tolerability and changes in global clinical impression with an multiallergen immunotherapy treatment without dilutional effect in polyallergic patients. Patients & methods: This observational prospective study included patients with allergic rhinitis-rhinoconjunctivitis with or without asthm...
journal_title:Immunotherapy
pub_type: 杂志文章
doi:10.2217/imt-2019-0187
更新日期:2020-01-01 00:00:00
abstract::Although vaccination significantly reduces influenza severity, seasonal human influenza epidemics still cause more than 250,000 deaths annually. Vaccine efficacy is limited in high-risk populations such as infants, the elderly and immunosuppressed individuals. In the event of an influenza pandemic (such as the 2009 H1...
journal_title:Immunotherapy
pub_type: 杂志文章,评审
doi:10.2217/imt.11.167
更新日期:2012-02-01 00:00:00
abstract::Only a minority of studies addressing the association between immune-related adverse events (IrAE) and outcome considered the immortal time bias, with conflicting results. PubMed, Embase, Web of Science and Scopus were searched through 2 January 2020. Studies reporting the impact of IrAE on outcome in patients treated...
journal_title:Immunotherapy
pub_type: 杂志文章
doi:10.2217/imt-2020-0179
更新日期:2021-02-01 00:00:00
abstract::Immunotherapy of cancer is a rapidly developing field; one such development is the manipulation and use of natural killer (NK) cells. These cells with 'killer instincts' are an attractive cell to utilize, as they are directly reactive toward tumor and could potentially activate the endogenous adaptive immune system. T...
journal_title:Immunotherapy
pub_type: 杂志文章,评审
doi:10.2217/imt.09.36
更新日期:2009-07-01 00:00:00
abstract::Brain tumors present unique therapeutic challenges and they include glioblastoma (GBM) and metastases from cancers of other organs. Current treatment options are limited and include surgical resection, radiation therapy, laser interstitial thermal therapy and chemotherapy. Although much research has been done on the d...
journal_title:Immunotherapy
pub_type: 杂志文章
doi:10.2217/imt-2019-0023
更新日期:2019-10-01 00:00:00
abstract::Aim: To evaluate treatment results in advanced/metastatic melanoma patients treated with anti-PD-1 immunotherapy in routine practice in oncology centers in Poland. Methods: Multicenter retrospective analysis included 499 patients with unresectable/metastatic (stage IIIC-IV) melanoma treated with anti-PD-1 in first-lin...
journal_title:Immunotherapy
pub_type: 杂志文章
doi:10.2217/imt-2020-0217
更新日期:2021-03-01 00:00:00
abstract::The poor prognosis of pancreatic cancer patients signifies a need for radically new therapeutic strategies. Tumor-targeted oncolytic viruses have emerged as attractive therapeutic candidates for cancer treatment due to their inherent ability to specifically target and lyse tumor cells as well as induce antitumor effec...
journal_title:Immunotherapy
pub_type: 杂志文章,评审
doi:10.2217/imt.15.90
更新日期:2015-01-01 00:00:00
abstract::Immunotherapy strategies for cancer are focused on inducing effective and specific cytotoxic responses mediated by CD8 T cells. On the other hand, immunosuppressive mechanisms induced by the tumor, such as the generation of tumor-specific CD4(+)CD25(+)FoxP3(+) Tregs, conspire against the efficacy of immunotherapies. I...
journal_title:Immunotherapy
pub_type: 杂志文章
doi:10.2217/imt.12.39
更新日期:2012-05-01 00:00:00
abstract::Aim: To investigate whether and how CD4+ T cells contribute to ILC2 activation during respiratory syncytial virus (RSV) infection. Methods: The methods of flow cytometry, quantitative PCR and ELISA were used in the present study. Results: Depletion of CD4+ T cells diminished the numbers of lung ILC2s as well as their ...
journal_title:Immunotherapy
pub_type: 杂志文章
doi:10.2217/imt-2019-0084
更新日期:2019-10-01 00:00:00
abstract:AIM:This meta-analysis aims at assessing the correlation of PD-L1 levels and response PD-1/PD-L1 inhibitors in advanced malignant melanoma. METHODS:Eligible studies included those evaluating PD-1/PD-L1 inhibitors in advanced melanoma and correlating the outcomes to PD-L1 levels. RESULTS:After preclusion of ineligible...
journal_title:Immunotherapy
pub_type: 杂志文章,meta分析
doi:10.2217/imt-2016-0025
更新日期:2016-09-01 00:00:00
abstract::Chronic rhinosinusitis with nasal polyposis (CRSwNP) imparts a significant healthcare challenge, resulting in diminished quality of life for patients and high costs with resource utilization for disease management. Understanding of CRSwNP pathophysiology has progressively evolved and the identification of various infl...
journal_title:Immunotherapy
pub_type: 杂志文章,评审
doi:10.2217/imt-2019-0191
更新日期:2020-02-01 00:00:00
abstract::Aim: Autologous hematopoietic stem cell transplantation (ASCT) is the standard-of-care curative treatment for relapsed or refractory diffuse large B-cell lymphoma (RR-DLBCL), but the relapse rate is usually high. Materials & methods: In this study, we treated 14 RR-DLBCL patients by combining ASCT and anti-CD19 chimer...
journal_title:Immunotherapy
pub_type: 杂志文章
doi:10.2217/imt-2020-0075
更新日期:2020-09-01 00:00:00
abstract::While the etiology of multiple sclerosis (MS) remains unclear, research from the clinic and preclinical models identified the essential role of inflammation and demyelination in the pathogenesis of MS. Current treatments focused on anti-inflammatory processes are effective against acute episodes and relapsing-remittin...
journal_title:Immunotherapy
pub_type: 杂志文章,评审
doi:10.2217/imt-2018-0153
更新日期:2019-02-01 00:00:00
abstract::Aim: To assess the safety and effectiveness of an allergen immunotherapy (AIT) with a microcrystalline tyrosine-associated mite allergoid in real-world patients with allergic rhinitis (AR). Materials & methods: Retrospective, multicenter study assessing the safety of AIT in patients aged 5 to 65 years with AR, with or...
journal_title:Immunotherapy
pub_type: 杂志文章
doi:10.2217/imt-2020-0194
更新日期:2020-09-01 00:00:00
abstract::Hematopoietic stem cell transplantation is the treatment of choice for many hematologic malignancies and genetic diseases. However, viral infections continue to account for substantial post-transplant morbidity and mortality. While antiviral drugs are available against some viruses, they are associated with significan...
journal_title:Immunotherapy
pub_type: 杂志文章,评审
doi:10.2217/imt.15.43
更新日期:2015-01-01 00:00:00
abstract:AIMS:In IgA nephropathy, circulating immune complexes containing IgA1 are deposited on the glomerular mesangium, causing mesangial cell proliferation and acceleration of extracellular matrix production. The suppressive effect of jacalin, a galactose-binding lectin, on IgA production in vitro was determined. MATERIALS ...
journal_title:Immunotherapy
pub_type: 杂志文章
doi:10.2217/imt.12.125
更新日期:2012-12-01 00:00:00
abstract::Heat-shock proteins (HSPs) have been involved in different functions including chaperone activity, protein folding, apoptosis, autophagy and immunity. The HSP families have powerful effects on the stimulation of innate immune responses through Toll-like receptors and scavenger receptors. Moreover, HSP-mediated phagocy...
journal_title:Immunotherapy
pub_type: 杂志文章,评审
doi:10.2217/imt-2018-0105
更新日期:2019-02-01 00:00:00
abstract::After the first wave of the tsunami of immune checkpoint inhibitors, 2016 was marked by the second wave, revealed by numerous US FDA approvals, publications and abstracts in relation with these drugs in different cancers and settings. First, we reported all new indications of anti-CTLA4, anti-programmed cell death pro...
journal_title:Immunotherapy
pub_type: 杂志文章,评审
doi:10.2217/imt-2017-0029
更新日期:2017-06-01 00:00:00
abstract::Pediatric eosinophilic esophagitis is an inflammatory condition associated with marked eosinophil accumulation in the mucosal tissues of the esophagus. Eosinophils are major proinflammatory cells thought to make a major contribution to allergic diseases that affect the upper and lower airways, skin and GI tract. IL-5 ...
journal_title:Immunotherapy
pub_type: 杂志文章
doi:10.2217/imt.10.41
更新日期:2010-07-01 00:00:00
abstract::Acute pyelonephritis is an infection of the renal parenchyma and renal pelvis. When it is caused by a typical pathogen in an immunocompetent female patient with normal urinary tract, it is considered uncomplicated. In all other cases, sepsis is the most worrisome complication. In the event of sepsis, patients should b...
journal_title:Immunotherapy
pub_type: 杂志文章,评审
doi:10.2217/imt.15.98
更新日期:2016-01-01 00:00:00
abstract::In recent years, there have been reports of immunotherapy inducing objective clinical responses in limited numbers of cancer patients. More frequently, however, clinical responses are not observed. Understanding the immunological mechanisms underlying successful immunotherapy are crucial if the field is to move forwar...
journal_title:Immunotherapy
pub_type: 评论,杂志文章
doi:10.2217/imt.11.62
更新日期:2011-06-01 00:00:00
abstract:AIM:Few studies have compared cluster immunotherapy and conventional administration regimens. The aim of this study was to establish the safety profile of these different regimens in patients with allergic respiratory diseases who received index-of-reactivity (IR)-standardized allergen extracts by the subcutaneous rout...
journal_title:Immunotherapy
pub_type: 杂志文章,多中心研究
doi:10.2217/imt.13.133
更新日期:2013-12-01 00:00:00