Abstract:
:Pediatric eosinophilic esophagitis is an inflammatory condition associated with marked eosinophil accumulation in the mucosal tissues of the esophagus. Eosinophils are major proinflammatory cells thought to make a major contribution to allergic diseases that affect the upper and lower airways, skin and GI tract. IL-5 is central to eosinophil maturation and release from the bone marrow, and their subsequent accumulation, activation and persistence in the tissues. Reslizumab (Cinquil, Ception Therapeutics Inc., PA, USA) is a humanized monoclonal antibody with potent IL-5 neutralizing effects that represents a potential treatment for eosinophilic diseases. This article considers the current status of the clinical development of reslizumab for pediatric eosinophilic esophagitis.
journal_name
Immunotherapyjournal_title
Immunotherapyauthors
Walsh GMdoi
10.2217/imt.10.41subject
Has Abstractpub_date
2010-07-01 00:00:00pages
461-5issue
4eissn
1750-743Xissn
1750-7448journal_volume
2pub_type
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