Antibodies to porin antigens of Salmonella typhi induced during typhoid infection in humans.

abstract：:The structural gene of pneumolysin was randomly mutagenized. A screen, developed to identify mutants with reduced hemolytic activity, identified substitutions within the cysteine-containing region and also at residues toward the N terminus of the toxin. These are the first reported changes within the N-terminal region...

journal_title：Infection and immunity

authors： Hill J,Andrew PW,Mitchell TJ

更新日期：1994-02-01 00:00:00

abstract：:Disruption of neutrophils causes the release of a cytoplasmic protein which can inhibit the growth of Candida albicans without killing the organisms. The present study was undertaken with a combined system in which candidacidal and candidastatic activities of human neutrophils could be compared. In this system it was ...

journal_title：Infection and immunity

authors： Sohnle PG,Collins-Lech C

更新日期：1990-08-01 00:00:00

abstract：:Escherichia coli F-18 is a human fecal isolate that makes type 1 fimbriae, encoded by the fim gene cluster, and is an excellent colonizer of the streptomycin-treated mouse intestine. E. coli F-18 fimA::tet, lacking type 1 fimbriae, was constructed by bacteriophage P1 transduction of the fim region of the E. coli K-12 ...

journal_title：Infection and immunity

authors： Sweeney NJ,Klemm P,McCormick BA,Moller-Nielsen E,Utley M,Schembri MA,Laux DC,Cohen PS

更新日期：1996-09-01 00:00:00

abstract：:Immunization with avirulent Salmonella typhimurium strain SL3235, a smooth, aroA- derivative, was shown to induce high levels of resistance to challenge with virulent S. typhimurium in innately hypersusceptible C3H/HeJ mice and inherently resistant C3H/HeNCrlBR mice. Strain SL3235 is one of a class of avirulent aroA- ...

journal_title：Infection and immunity

authors： Killar LM,Eisenstein TK

更新日期：1985-03-01 00:00:00

abstract：:The virulence plasmids of Salmonella typhimurium and other invasive Salmonella serovars have long been associated with the ability of these bacteria to cause systemic infection beyond the intestines in orally inoculated animals. Genetic analysis of virulence genes on the high-molecular-weight plasmids has revealed tha...

journal_title：Infection and immunity

authors： Gulig PA,Doyle TJ

更新日期：1993-02-01 00:00:00

abstract：:The lymphogranuloma venereum (LGV) and trachoma biovars of Chlamydia trachomatis exhibit differences in biological properties both in vivo and in vitro. To identify analogous biochemical differences, we studied the molecular charges of chlamydial outer membrane proteins (OMPs) by means of isoelectric focusing and none...

journal_title：Infection and immunity

authors： Batteiger BE,Newhall WJ 5th,Jones RB

更新日期：1985-11-01 00:00:00

abstract：:We investigated the effect of a pH 4-treated human immunoglobulin preparation for intravenous use (pH4-G) on the production of tumor necrosis factor alpha (TNF-alpha) in vivo. The level of TNF-alpha in the sera of rabbits receiving pH4-G before lipopolysaccharide (LPS) injection was lower than that in rabbits receivin...

journal_title：Infection and immunity

authors： Shimozato T,Iwata M,Tamura N

更新日期：1990-05-01 00:00:00

abstract：:Outer membrane porin genes of Salmonella typhimurium, including ompC, ompF, and tppB, are regulated by the products of ompB, a two-component regulatory locus encoding OmpR and EnvZ. S. typhimurium ompR mutants are attenuated in mice, but to date no one has studied the intracellular trafficking of S. typhimurium porin-...

journal_title：Infection and immunity

authors： Mills SD,Ruschkowski SR,Stein MA,Finlay BB

更新日期：1998-04-01 00:00:00

abstract：:Many pathogenic microbes have multiple virulence factors that can cause damage to the host and thus contribute to an overall virulence phenotype for that organism. Although current techniques are suitable for demonstrating that a particular microbial characteristic contributes to virulence, no formal approach for defi...

journal_title：Infection and immunity

authors： McClelland EE,Bernhardt P,Casadevall A

更新日期：2006-03-01 00:00:00

abstract：:Sera from adult periodontitis patients were analyzed for antibody activity against surface antigens of Bacteroides gingivalis by immunoblotting analysis. ...

journal_title：Infection and immunity

authors： Naito Y,Okuda K,Takazoe I

更新日期：1987-03-01 00:00:00

abstract：:The importance of CD4+ cells and gamma interferon (IFN-gamma) in the resolution of established Cryptosporidium parvum infection was investigated with a murine model of cryptosporidiosis in severe combined immunodeficient (SCID) mice. C. parvum-infected SCID mice were reconstituted with spleen cells from immunocompeten...

journal_title：Infection and immunity

authors： Chen W,Harp JA,Harmsen AG

更新日期：1993-09-01 00:00:00

abstract：:Epitope mapping of outer surface protein C (OspC) by using sera from patients with neuroborreliosis led to the identification of one single major immunodominant epitope within the C-terminal 10 amino acid residues. Peptide binding studies and alanine replacement scanning of the C-terminal decapeptide, PVVAESPKKP, reve...

journal_title：Infection and immunity

authors： Mathiesen MJ,Holm A,Christiansen M,Blom J,Hansen K,Ostergaard S,Theisen M

更新日期：1998-09-01 00:00:00

abstract：:Intestinal mucus is postulated to play a role in preventing colonization of the gastrointestinal tract by microbial pathogens. To evaluate the ability of both crude mucus and purified mucin, a glycoprotein of goblet cell origin, to inhibit mucosal adherence of enteric pathogens, we examined whether mucus and mucin der...

journal_title：Infection and immunity

authors： Drumm B,Roberton AM,Sherman PM

更新日期：1988-09-01 00:00:00

abstract：:Gonococci do not readily cause disseminated infection in mice. To simulate some of the conditions leading to disseminated gonococcal infection in women, we suspended gonococci in mucin plus hemoglobin and studied the development of gonococcal bacteremia. The mucin-hemoglobin mixture was used because the menstruum appe...

journal_title：Infection and immunity

authors： Corbeil LB,Wunderlich AC,Corbeil RR,McCutchan JA,Ito JI Jr,Braude AI

更新日期：1979-12-01 00:00:00

abstract：:Borrelia burgdorferi synthesizes a variety of differentially regulated outer surface lipoproteins in the tick vector and in vertebrate hosts. Among these is OspD, a protein that is highly induced in vitro by conditions that mimic the tick environment. Using genetically engineered strains in which ospD is deleted, we d...

journal_title：Infection and immunity

authors： Stewart PE,Bestor A,Cullen JN,Rosa PA

更新日期：2008-05-01 00:00:00

abstract：:Previously, we isolated a high-molecular-weight immunogenic polysaccharide (designated PS) from Pseudomonas aeruginosa immunotype 1 (IT-1). The method which we used was modified to permit the isolation of a similar PS from P. aeruginosa IT-2. This antigen was composed primarily of carbohydrate, had a complex monosacch...

journal_title：Infection and immunity

authors： Pier GB,Sidberry HF,Sadoff JC

更新日期：1981-11-01 00:00:00

abstract：:Neuronal dysfunction can occur in the course of sepsis without meningitis. Sepsis-associated neuronal damage (SAND) was observed in the hippocampus within hours in experimental pneumococcal bacteremia. Intravascular challenge with purified bacterial cell wall recapitulated SAND. SAND persisted in PAFr(-/-) mice but wa...

journal_title：Infection and immunity

authors： Orihuela CJ,Fillon S,Smith-Sielicki SH,El Kasmi KC,Gao G,Soulis K,Patil A,Murray PJ,Tuomanen EI

更新日期：2006-07-01 00:00:00

abstract：:The protective efficacy of Mycobacterium bovis BCG can be markedly augmented by stable integration of Mycobacterium tuberculosis genomic region RD1. BCG complemented with RD1 (BCG::RD1) encodes nine additional proteins. Among them, 10-kDa culture filtrate protein (CFP-10) and ESAT-6 (6-kDa early secreted antigenic tar...

journal_title：Infection and immunity

authors： Demangel C,Brodin P,Cockle PJ,Brosch R,Majlessi L,Leclerc C,Cole ST

更新日期：2004-04-01 00:00:00

abstract：:Guinea pigs sensitized by repeated skin testing with potent, merthiolated coccidioidin, equal to Smith standard, exhibited erythema, edema, and an induration-like reaction to intradermal injection of the preparation. No statistically significant migration inhibition of peritoneal exudate macrophages from these animals...

journal_title：Infection and immunity

authors： Sinski JT,Reed GL,Kelley LM,LeFebvre R

更新日期：1973-02-01 00:00:00

abstract：:Rhodococcus equi is a facultative intracellular pathogen of macrophages, relying on the presence of a conjugative virulence plasmid harboring a 21-kb pathogenicity island (PAI) for growth in host macrophages. The PAI encodes a family of 6 virulence-associated proteins (Vaps) in addition to 20 other proteins. The contr...

journal_title：Infection and immunity

authors： Coulson GB,Miranda-CasoLuengo AA,Miranda-CasoLuengo R,Wang X,Oliver J,Willingham-Lane JM,Meijer WG,Hondalus MK

更新日期：2015-08-01 00:00:00

abstract：:Legionella pneumophila, the gram-negative agent of Legionnaires' disease, possesses type IV pili and a type II protein secretion (Lsp) system, both of which are dependent upon the PilD prepilin peptidase. By analyzing multiple pilD mutants and various types of Lsp mutants as well as performing trans-complementation of...

journal_title：Infection and immunity

authors： Rossier O,Starkenburg SR,Cianciotto NP

更新日期：2004-01-01 00:00:00

abstract：:Trypanosome-activated mouse peritoneal macrophages phagocytized and digested Trypanosoma brucei in vitro and in vivo, but in the absence of specific antiserum and complement the degree of phagocytosis was minimal. Ultrastructurally, the parasites attached to the macrophage by their flagella, and ingestion proceeded fl...

journal_title：Infection and immunity

authors： Stevens DR,Moulton JE

更新日期：1978-03-01 00:00:00

abstract：:Biological properties of two strains of simian virus 40 (SV40) from brains of two patients with progressive multifocal leukoencephalopathy (PML) have been compared to those of a standard laboratory strain of SV40. Infectivity of both SV40-PML viruses was resistant to treatment with chloroform, low pH, and 50 C for 120...

journal_title：Infection and immunity

authors： Narayan O,Weiner LP

更新日期：1974-07-01 00:00:00

abstract：:We have previously demonstrated that fibronectin mediates streptococcal adhesion to host cells and that streptococci interact primarily with the N-terminal domain of fibronectin. FBP54 is a 54-kDa protein from group A streptococci that binds fibronectin. In this report, we show that the N-terminal domain of fibronecti...

journal_title：Infection and immunity

authors： Courtney HS,Dale JB,Hasty DI

更新日期：1996-07-01 00:00:00

abstract：:We found that oral immunization with flagellum-defective mutant strains of Salmonella enterica serovar Typhimurium with the ClpXP-deficient background protected mice against oral challenge with the virulent strain. These data indicate that Salmonella flagellin is not a dominant protective antigen in oral immunization ...

journal_title：Infection and immunity

authors： Kodama C,Matsui H

更新日期：2004-04-01 00:00:00

abstract：:The intraerythrocytic apicomplexan Babesia microti, the primary causative agent of human babesiosis, is a major public health concern in the United States and elsewhere. Apicomplexans utilize a multiprotein complex that includes a type I membrane protein called apical membrane antigen 1 (AMA1) to invade host cells. We...

journal_title：Infection and immunity

authors： Moitra P,Zheng H,Anantharaman V,Banerjee R,Takeda K,Kozakai Y,Lepore T,Krause PJ,Aravind L,Kumar S

更新日期：2015-10-01 00:00:00

abstract：:Patients with chronic bronchitis are colonized by and may develop acute bronchopulmonary infection due to nontypable Haemophilus influenzae (NTHI) despite the presence of bactericidal and opsonizing antibody to the infecting organism. To test the hypothesis that secretory immunoglobulin A (IgA) interferes with host de...

journal_title：Infection and immunity

authors： Musher DM,Goree A,Baughn RE,Birdsall HH

更新日期：1984-07-01 00:00:00

abstract：:Antibodies against mumps virus have been studied by using immunoglobulin class-specific indicators labeled with (125)I in the radioimmunoassay (RIA) procedure. The immunoglobulins in paired acute and convalescent sera were allowed to react with mumps virus in a solid-phase RIA system. Class-specific immunoglobulin ind...

journal_title：Infection and immunity

authors： Daugharty H,Warfield DT,Hemingway WD,Casey HL

更新日期：1973-03-01 00:00:00

abstract：:Salmonella pathogenicity island 12 (SPI-12) of Salmonella enterica serovar Typhimurium is a 15-kb region that encompasses genes STM2230 to STM2245 and encodes a remnant phage known to contribute to bacterial virulence. In mouse infection experiments and replication assays in macrophages, we demonstrated a role for fou...

journal_title：Infection and immunity

authors： Tomljenovic-Berube AM,Henriksbo B,Porwollik S,Cooper CA,Tuinema BR,McClelland M,Coombes BK

更新日期：2013-07-01 00:00:00

abstract：:Urinary tract infection (UTI) is the second most common infection in humans, making it a global health priority. Nearly half of all women will experience a symptomatic UTI, with uropathogenic Escherichia coli (UPEC) being the major causative agent of the infection. Although there has been extensive research on UPEC vi...

journal_title：Infection and immunity

authors： Sintsova A,Smith S,Subashchandrabose S,Mobley HL

更新日期：2018-02-20 00:00:00