Abstract：
AIM:To evaluate the effect of the prebiotic (PREB) mannan oligosaccharide (MOS) on the progression of the experimental periodontitis (EP) and intestinal morphology in rats. MATERIALS AND METHODS:Forty rats were randomly allocated into groups (n = 10): C (control), PREB, EP and EP-PREB. Groups PREB and EP-PREB received MOS incorporated into the feed daily. After 30 days, groups EP and EP-PREB received a cotton ligature around their mandibular first molars, kept for 14 days. Morphometrical, histomorphometrical, microcomputed tomography, gene expression analyses and immunohistochemistry were performed. Data were statistically analysed (p < 0.05). RESULTS:Group EP-PREB showed less interproximal bone loss, area without bone in the furcation and bone porosity, and greater bone mineral density than group EP (p < 0.05). It was also observed a significant decrease in IL-10 and IFN-γ gene expression, besides a decrease in TNF-α and IL-1β and an increase in TGF-β immunolabeling score for group EP-PREB. Group EP-PREB also presented villous height and crept depth values similar to group C, while group EP presented reduced values (p < 0.05). CONCLUSION:It can be concluded that the oral administration of MOS promotes a protective effect against alveolar bone loss caused by EP in rats, modifying histologic and immune-inflammatory parameters, in addition to protecting the intestine.
journal_name
J Clin Periodontoljournal_title
Journal of clinical periodontologyauthors
Levi YLAS,Novais GS,Dias RB,Andraus RAC,Messora MR,Neto HB,Ervolino E,Santinoni CS,Maia LPdoi
10.1111/jcpe.12987subject
Has Abstractpub_date
2018-09-01 00:00:00pages
1078-1089issue
9eissn
0303-6979issn
1600-051Xjournal_volume
45pub_type
杂志文章abstract：AIM:The study was set to evaluate the validity of subjective jaw bone quality assessment. MATERIALS AND METHODS:A total of 298 patients (198 females, mean age 56.4) were treated with oral implants at the Periodontology Department at the University Hospital of KUL. A total of 761 TiUnite implants have been installed. S...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051X.2007.01047.x
更新日期：2007-04-01 00:00:00
abstract：OBJECTIVES:This case-control study examined polymorphisms at the interleukin-1 gene in relation to periodontal status, subgingival bacteria and systemic antibodies to periodontal microbiota. METHODS:132 periodontitis patients were age- and gender-matched with 73 periodontally intact controls. Full-mouth clinical asses...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1034/j.1600-051x.2001.028005389.x
更新日期：2001-05-01 00:00:00
abstract：AIM:To present the 6-year results of a randomized-controlled clinical trial evaluating guided tissue regeneration (GTR) combined with or without deproteinized bovine bone mineral (DBBM) in intrabony defects. MATERIAL & METHODS:In each of 45 patients, one defect was treated with GTR combined with DBBM hydrated in salin...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章,随机对照试验
doi：10.1111/j.1600-051X.2009.01520.x
更新日期：2010-02-01 00:00:00
abstract：AIM:Reports regarding prevalence of peri-implant diseases show widely varying prevalence rates, which can be explained partially by variable diagnostic criteria adopted. Furthermore, several different factors have been associated with peri-implant diseases. Hence, the aim of this cross-sectional study is to (a) determi...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/jcpe.13111
更新日期：2019-05-01 00:00:00
abstract：OBJECTIVES:To compare the prevalence of periodontal disease between two randomly selected population-based studies (the Oral Infections and Vascular Disease Epidemiology Study (INVEST) and the Study of Health in Pomerania (SHIP)) and address relevant methodological issues. METHODS:Comparison was restricted to 55- to 8...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/jcpe.12018
更新日期：2012-12-01 00:00:00
abstract：OBJECTIVES:The aim of this study was to conduct a review on quality of reporting on descriptive studies in implant dentistry using the STROBE Statement and to analyse possible changes in quality of reporting on descriptive studies in implant dentistry over time. MATERIAL AND METHODS:A hand search to select descriptive...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章,评审
doi：10.1111/j.1600-051X.2011.01834.x
更新日期：2012-02-01 00:00:00
abstract：AIMS:Both, vitamin D3 and human periodontal ligament cells (hPDLCs) possess immunosuppressive properties, but their combined effect on immune cells has never been investigated. Here, we analysed the impact of vitamin D3 on the immunosuppressive properties of hPDLCs towards CD4+ T lymphocytes. MATERIAL AND METHODS:Allo...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/jcpe.13283
更新日期：2020-06-01 00:00:00
abstract：BACKGROUND/AIMS:There is little information about the occurrence and risk indicators for periodontal diseases in Latin America. The present study describes the prevalence, extent and severity of periodontal probing depth (PPD) and assesses the association between demographic, behavioural and environmental risk indicato...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051X.2005.00637.x
更新日期：2005-02-01 00:00:00
abstract：AIM:To investigate the in vivo role of gingipains in Porphyromonas gingivalis' virulence, and suggest a possible host mechanisms through which the bacteria cause alveolar bone loss. MATERIALS AND METHODS:Mice were orally infected with P. gingivalis wild type, or the gingipains mutants (RgpA⁻, Kgp⁻, RgpA⁻/Kgp⁻). Mice w...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/jcpe.12139
更新日期：2013-10-01 00:00:00
abstract：AIM:The primary aim of the study was to systematically map registration records on periodontal medicine in clinical trial registers. The secondary aim was to assess the evolution of periodontal medicine in clinical periodontal research as a whole. MATERIAL AND METHODS:We searched all registration records related to pe...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章,评审
doi：10.1111/jcpe.12534
更新日期：2016-05-01 00:00:00
abstract：:Platelet-derived growth factor (PDGF) and the glucocorticoid dexamethasone combined with a collagen carrier matrix (CM) induced regeneration of the periodontium in monkeys. Regeneration was stringently defined as: (1) new cementum, (2) new supra-crestal bone extending coronally from the residual alveolar interdental s...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051x.1993.tb00403.x
更新日期：1993-08-01 00:00:00
abstract：:The healing of the dento-epithelial junction following the use of dental floss was studied on 28 first premolars in seven children who were under orthodontic treatment. On the mesial surfaces the floss was brought to the depth of the pocket and moved back and forth three to five times, while being pressed against the ...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051x.1981.tb02354.x
更新日期：1981-04-01 00:00:00
abstract：:This report will focus attention on the diagnostic and therapeutic difficulties involved in a patient who presented with a gingival papillary-verrucous lesion, which subsequently developed into a squamous cell carcinoma. ...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051x.1987.tb01515.x
更新日期：1987-01-01 00:00:00
abstract：OBJECTIVES:This aim of this study was to develop and assess a technique that could be used to assess accurately the gingival volume changes seen in drug-induced gingival overgrowth by the analysis of data obtained from an entire gingival surface by means of three-dimensional imaging. MATERIAL AND METHODS:Stone dental ...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051X.2005.00769.x
更新日期：2005-10-01 00:00:00
abstract：AIM:To analyse, through a pre-clinical in vivo model, the possible mechanisms linking depression and periodontitis at behavioural, microbiological and molecular levels. MATERIALS AND METHODS:Periodontitis (P) was induced in Wistar:Han rats (oral gavages with Porphyromonas gingivalis and Fusobacterium nucleatum) during...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/jcpe.13420
更新日期：2021-01-12 00:00:00
abstract：AIM:The aims were to evaluate and compare the periodontal status of unilateral impacted maxillary canines treated by a combined surgical-orthodontic technique with that of normally erupted controlateral canines. MATERIAL AND METHODS:One hundred and twenty-five patients, consecutively enrolled, aged between 12.8 and 52...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051X.2006.01042.x
更新日期：2007-03-01 00:00:00
abstract：AIM:To evaluate the 1-year outcome of Minimally Invasive Single Implant Treatment (M.I.S.I.T.) based on ridge preservation and contour augmentation in patients with a high aesthetic risk profile. MATERIALS AND METHODS:Periodontally healthy non-smoking patients with a failing tooth in the anterior maxilla (15-25) were ...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/jcpe.12384
更新日期：2015-04-01 00:00:00
abstract：BACKGROUND:It was demonstrated that a marginal defect of about 1 mm between the bone wall and the metal surface after implant installation can heal with a high degree of bone fill and osseointegration. OBJECTIVE:The aim of the present animal experiment was to study bone healing at implant sites with hard tissue defect...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051X.2004.00502.x
更新日期：2004-04-01 00:00:00
abstract：OBJECTIVES:The primary aim was to address the following focused question: What is the clinical effect of laser application compared with mechanical debridement in non-surgical periodontal therapy in patients with chronic periodontitis? A secondary aim was to survey the relevant literature in relation to safety of laser...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章,meta分析,评审
doi：10.1111/j.1600-051X.2008.01259.x
更新日期：2008-09-01 00:00:00
abstract：:Previous in vivo studies suggested that a high substratum surface free energy (s.f.e.) and an increased surface roughness facilitate the supragingival plaque accumulation. It is the aim of this clinical trial to explore the "relative" effect of a combination of these surface characteristics on plaque growth. 2 strips,...
journal_title：Journal of clinical periodontology
pub_type： 临床试验,杂志文章
doi：10.1111/j.1600-051x.1990.tb01077.x
更新日期：1990-03-01 00:00:00
abstract：:In a cross-sectional, epidemiological study of phenytoin induced gingival overgrowth in 77 institutionalized persons with epilepsy, the severity of the gum lesions was quantified by means of a precise new technique. Lesion severity was then compared statistically to other clinical and laboratory parameters. Positive c...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051x.1984.tb02214.x
更新日期：1984-04-01 00:00:00
abstract：BACKGROUND:The aim of this Systematic Review (SR) was to assess the clinical efficacy of periodontal plastic surgery procedures in the treatment of localized gingival recessions (Rec) with or without inter-dental clinical attachment loss (iCAL). MATERIAL AND METHODS:Electronic and hand searches were performed to ident...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章,评审
doi：10.1111/jcpe.12182
更新日期：2014-04-01 00:00:00
abstract：BACKGROUND AND AIMS:Periodontitis is an infection with an episodic nature of tissue support destruction. The aim of this work was to determine the levels of chemokines, cytokines, matrix metalloproteinase-13, periodontal pathogens and inflammatory cells in periodontal sites characterized by active periodontal connectiv...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051X.2007.01190.x
更新日期：2008-03-01 00:00:00
abstract：OBJECTIVE:To compare the short-term performance of subgingival local delivery of 2% minocycline gel and conventional subgingival debridement in supportive periodontal therapy (SPT) patients. METHODS:Forty adult patients having completed active treatment for moderate to advanced chronic periodontitis were included in a...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章,随机对照试验
doi：10.1111/j.1600-051X.2005.00879.x
更新日期：2006-02-01 00:00:00
abstract：BACKGROUND/AIMS:This study aimed to investigate the cytokine IL-1beta and its receptor antagonist IL-1ra in gingival crevicular fluid (GCF), in patients with adult periodontitis. METHOD:A total of 40 GCF samples were harvested from 10 subjects with moderate to severe adult periodontitis and 10 healthy controls. Subjec...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1034/j.1600-051x.2000.027010738.x
更新日期：2000-10-01 00:00:00
abstract：:The effects of CO2 lasers on human gingiva have been evaluated. Pulsed Nd:YAG lasers have only been available for clinical use in dentistry since 1990. This study evaluated the efficacy of a low-power pulsed laser in removing pocket lining epithelium in humans with moderate periodontitis. 24 specimens of gingival tiss...
journal_title：Journal of clinical periodontology
pub_type： 临床试验,杂志文章
doi：10.1111/j.1600-051x.1994.tb00735.x
更新日期：1994-07-01 00:00:00
abstract：AIMS:To update the existing scientific evidence on the efficacy of local antimicrobials as adjuncts to subgingival debridement in the treatment of chronic periodontitis. MATERIAL AND METHODS:Fifty-six papers were selected, reporting data from 52 different investigations. All the studies reported changes in probing poc...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章,meta分析,评审
doi：10.1111/jcpe.12026
更新日期：2013-03-01 00:00:00
abstract：:116 subjects were recruited from a population of patients previously treated for adult periodontitis and maintained in periodontal health by means of periodic prophylaxes every 3-6 months. The subjects were divided into a control (C) and a test (T) group. A total of 33 patients in the T group and 47 in the C group com...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051x.1989.tb01622.x
更新日期：1989-02-01 00:00:00
abstract：:Every periodontal researcher have been taught, and every textbook in periodontics have advocated, that a phase in which the patient is meticulously motivated and instructed in proper oral hygiene-the oral hygiene phase-must be included in any periodontal intervention. However, how is this oral hygiene phase actually p...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章,评审
doi：10.1111/jcpe.13109
更新日期：2019-05-01 00:00:00
abstract：:The objective of this study was to evaluate the effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) concentration on regeneration of alveolar bone and cementum, and on associated root resorption and ankylosis. Contralateral, critical size, supra-alveolar, periodontal defects were surgically produced and...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1034/j.1600-051x.1999.260610.x
更新日期：1999-06-01 00:00:00
