当前位置： SCI文献检索 > JOURNAL OF CLINICAL PERIODONTOLOGY期刊下所有文献 > The role of RgpA in the pathogenicity of Porphyromonas gingivalis in the murine periodontitis model.

The role of RgpA in the pathogenicity of Porphyromonas gingivalis in the murine periodontitis model.

Abstract：

AIM:To investigate the in vivo role of gingipains in Porphyromonas gingivalis' virulence, and suggest a possible host mechanisms through which the bacteria cause alveolar bone loss. MATERIALS AND METHODS:Mice were orally infected with P. gingivalis wild type, or the gingipains mutants (RgpA⁻, Kgp⁻, RgpA⁻/Kgp⁻). Mice were analysed for alveolar bone loss using micro-computed tomography. The molecular effects of the proteases were evaluated using the subcutaneous chamber model. Mice were infected with P. gingivalis wild type or mutants. Exudates were analysed for cytokine and leukocytes levels, in vivo phagocytosis, P. gingivalis survival and serum anti-P. gingivalis IgG titres. RESULTS:Only RgpA-expressing bacteria induced significantly alveolar bone loss, and suppressed phagocytosis resulting in increased survival of P. gingivalis in the chamber exudates. In addition, RgpA-expressing bacteria induced higher levels of leukocytes and cytokines 2 h post-infection, and reduced levels of serum anti-P. gingivalis IgG titres 7 days post-infection. CONCLUSIONS:Our findings showed that elimination of RgpA from P. gingivalis diminished inflammation, but augmented phagocytosis and antibody titres, coincidental with reduced alveolar bone loss. These findings support the hypothesis that RgpA is a critical virulence factor in the pathogenesis of experimental periodontitis in mice.

journal_name

J Clin Periodontol

journal_title

Journal of clinical periodontology

authors

Wilensky A,Polak D,Houri-Haddad Y,Shapira L

doi

10.1111/jcpe.12139

subject

Has Abstract

pub_date

2013-10-01 00:00:00

pages

924-32

issue

10

eissn

0303-6979

issn

1600-051X

journal_volume

40

pub_type

杂志文章

相关文献

JOURNAL OF CLINICAL PERIODONTOLOGY文献大全
  • Effects of the prebiotic mannan oligosaccharide on the experimental periodontitis in rats.

    abstract：AIM:To evaluate the effect of the prebiotic (PREB) mannan oligosaccharide (MOS) on the progression of the experimental periodontitis (EP) and intestinal morphology in rats. MATERIALS AND METHODS:Forty rats were randomly allocated into groups (n = 10): C (control), PREB, EP and EP-PREB. Groups PREB and EP-PREB received...

    journal_title：Journal of clinical periodontology

    pub_type： 杂志文章

    doi：10.1111/jcpe.12987

    authors： Levi YLAS,Novais GS,Dias RB,Andraus RAC,Messora MR,Neto HB,Ervolino E,Santinoni CS,Maia LP

    更新日期：2018-09-01 00:00:00

  • Differences in the inflammatory response in young and old human subjects during the course of experimental gingivitis.

    abstract：:The aim of the present experiment was to study changes in (i) the composition of the inflammatory cell infiltrates and (ii) levels of alpha 2-macroglobulin, lactoferrin and IgG subclasses in gingival crevicular fluid in young and old individuals during 3 weeks of plaque formation. To establish healthy gingival conditi...

    journal_title：Journal of clinical periodontology

    pub_type： 杂志文章

    doi：10.1034/j.1600-051x.1999.260707.x

    authors： Fransson C,Mooney J,Kinane DF,Berglundh T

    更新日期：1999-07-01 00:00:00

  • Subgingival instrumentation for treatment of periodontitis. A systematic review.

    abstract：OBJECTIVES:To evaluate the efficacy of subgingival instrumentation (PICOS-1), sonic/ultrasonic/hand instruments (PICOS-2) and different subgingival instrumentation delivery protocols (PICOS-3) to treat periodontitis. METHODS:Systematic electronic search (CENTRAL/MEDLINE/EMBASE/SCOPUS/LILACS) to March 2019 was conducte...

    journal_title：Journal of clinical periodontology

    pub_type： 杂志文章,评审

    doi：10.1111/jcpe.13245

    authors： Suvan J,Leira Y,Moreno Sancho FM,Graziani F,Derks J,Tomasi C

    更新日期：2020-07-01 00:00:00

  • The relationship of the periodontal status to fluoride levels of alveolar bone and tooth roots.

    abstract：:The periodontal status and fluoride levels of alveolar bone and tooth roots were compared for subjects from a high (2.5 ppm F) and a low (less than 0.05 ppm F) fluoride area. The plaque index, gingival index, probing depth and loss of attachment were measured to determine the periodontal status. The fluoride levels we...

    journal_title：Journal of clinical periodontology

    pub_type： 杂志文章

    doi：10.1111/j.1600-051x.1988.tb01573.x

    authors： Reddy J,Grobler SR

    更新日期：1988-04-01 00:00:00

  • The use of metronidazole and amoxicillin in the treatment of advanced periodontal disease. A prospective, controlled clinical trial.

    abstract：:The present clinical trial was performed to study the effect of systemic administration of metronidazole and amoxicillin as an adjunct to mechanical therapy in patients with advanced periodontal disease. 16 individuals, 10 female and 6 male, aged 35-58 years, with advanced periodontal disease were recruited. A baselin...

    journal_title：Journal of clinical periodontology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1111/j.1600-051x.1998.tb02455.x

    authors： Berglundh T,Krok L,Liljenberg B,Westfelt E,Serino G,Lindhe J

    更新日期：1998-05-01 00:00:00

  • Patterns of periodontal disease progression based on linear mixed models of clinical attachment loss.

    abstract：AIM:The goal of the present longitudinal cohort study was to examine patterns of periodontal disease progression at progressing sites and subjects defined based on linear mixed models (LMM) of clinical attachment loss (CAL). MATERIALS AND METHODS:A total of 113 periodontally healthy and 302 periodontitis subjects had ...

    journal_title：Journal of clinical periodontology

    pub_type： 杂志文章,多中心研究

    doi：10.1111/jcpe.12827

    authors： Teles R,Moss K,Preisser JS,Genco R,Giannobile WV,Corby P,Garcia N,Jared H,Torresyap G,Salazar E,Moya J,Howard C,Schifferle R,Falkner KL,Gillespie J,Dixon D,Cugini M

    更新日期：2018-01-01 00:00:00

  • Electron microscopic study of junctional and oral gingival epithelia in the juvenile and adult beagle dog.

    abstract：:A previous study demonstrated structural differences in the junctional epithelium between juvenile and adult dogs. In juveniles the junctional epithelium showed some resemblances to the oral gingival epithelium, and a cuticular structure at the dento-gingival junction was of particular interest. The oral gingival epit...

    journal_title：Journal of clinical periodontology

    pub_type： 杂志文章

    doi：10.1111/j.1600-051x.1979.tb01941.x

    authors： Matsson L,Theilade J,Attström R

    更新日期：1979-12-01 00:00:00

  • Epithelial remnants in the crestal periodontium of the deciduous and permanent dentition of beagle dogs.

    abstract：:The purpose of this study was to document and characterize epithelial remnants (EPRs) of the crestal periodontium of the deciduous dentition of a diphyodont and compare them with EPR units found in the corresponding area of the permanent dentition. 7 beagle dogs were used. At the age of 10 weeks (deciduous dentition) ...

    journal_title：Journal of clinical periodontology

    pub_type： 杂志文章

    doi：10.1111/j.1600-051x.1994.tb00754.x

    authors： Sterrett JD,Berglundh T,Lindhe J

    更新日期：1994-10-01 00:00:00

  • Morphology of polymorphonuclear neutrophils during periodontal disease in the cynomolgus monkey.

    abstract：:The polymorphonuclear neutrophil (PMN) appears to be an important cell in the protection of the host from pathogenic periodontal micro-organisms. The purpose of the present histological studies was to observe the emigration of the PMN from the gingival vessels to the periodontal pocket during gingivitis and ligature-i...

    journal_title：Journal of clinical periodontology

    pub_type： 杂志文章

    doi：10.1111/j.1600-051x.1985.tb01392.x

    authors： Brecx M,Patters MR

    更新日期：1985-08-01 00:00:00

  • Behaviour change counselling for tobacco use cessation and promotion of healthy lifestyles: a systematic review.

    abstract：AIM:To systematically assess the efficacy of oral health behaviour change counselling for tobacco use cessation (TUC) and the promotion of healthy lifestyles. MATERIALS AND METHODS:Systematic Reviews, Randomized (RCTs), and Controlled Clinical Trials (CCTs) were identified through an electronic search of four database...

    journal_title：Journal of clinical periodontology

    pub_type： 杂志文章,评审

    doi：10.1111/jcpe.12351

    authors： Ramseier CA,Suvan JE

    更新日期：2015-04-01 00:00:00

  • Particulate bioglass as a grafting material in the treatment of periodontal intrabony defects.

    abstract：:The present clinical trial was designed to evaluate the effects of a bioactive glass, Perioglas, in the treatment of periodontal intrabony defects. 20 patients, 23-55 years of age (44 sites), with intrabony defects completed the 1-year study. Teeth with furcation involvement were excluded. After completion of initial ...

    journal_title：Journal of clinical periodontology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1111/j.1600-051x.1997.tb00205.x

    authors： Zamet JS,Darbar UR,Griffiths GS,Bulman JS,Brägger U,Bürgin W,Newman HN

    更新日期：1997-06-01 00:00:00

  • Variation in periodontal referral by general dental practitioners.

    abstract：:This study investigated the extent of and reasons for variation in the periodontal referral patterns of general dental practitioners in Northern Ireland. A questionnaire was circulated to all general dental practitioners in Northern Ireland. This questionnaire investigated the management of periodontal disease in the ...

    journal_title：Journal of clinical periodontology

    pub_type： 杂志文章

    doi：10.1111/j.1600-051x.1998.tb02502.x

    authors： Linden GJ

    更新日期：1998-08-01 00:00:00

  • Analysis of the TGF-beta1 promoter polymorphism (C-509T) in patients with chronic periodontitis.

    abstract：BACKGROUND:A polymorphism in the promoter region of the transforming growth factor beta-1 (TGF-beta1) gene was described at position -509. This polymorphism represents a C-to-T base exchange, which creates a YY1 consensus sequence in an area involved with down transcription regulation. This polymorphism has been associ...

    journal_title：Journal of clinical periodontology

    pub_type： 杂志文章

    doi：10.1034/j.1600-051x.2003.00323.x

    authors： de Souza AP,Trevilatto PC,Scarel-Caminaga RM,de Brito RB,Line SR

    更新日期：2003-06-01 00:00:00

  • Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans and Treponema denticola detection in oral plaque samples using the polymerase chain reaction.

    abstract：:Detection of putative pathogens is critical for delineating the etiology and progression of periodontitis. In the present study, we have used a polymerase chain reaction (PCR) assay utilizing primers specific for the lkt A gene of Actinobacillus actinomycetemcomitans, the fimbrial gene of Porphyromonas gingivalis, and...

    journal_title：Journal of clinical periodontology

    pub_type： 杂志文章

    doi：10.1111/j.1600-051x.1996.tb02078.x

    authors： Watanabe K,Frommel TO

    更新日期：1996-03-01 00:00:00

  • Antagonists of Wnt/β-catenin signalling in the periodontitis associated with type 2 diabetes and smoking.

    abstract：AIM:This study evaluated the levels of sclerostin (SOST) and Dickkopf (DKK)-1 in the chronic periodontitis (CP) associated with type 2 diabetes (DM) and/or smoking. Relationships between SOST, DDK1, RANKL, OPG, IL-1ß, IL-6 and TNF-α, and pathogens were assessed. MATERIAL AND METHODS:The study population included non-d...

    journal_title：Journal of clinical periodontology

    pub_type： 杂志文章

    doi：10.1111/jcpe.12854

    authors： Miranda TS,Napimoga MH,Feres M,Marins LM,da Cruz DF,da Silva HDP,Duarte PM

    更新日期：2018-03-01 00:00:00

  • The gingival biotype assessed by experienced and inexperienced clinicians.

    abstract：AIM:A recent cluster analysis has identified three gingival biotypes among 100 periodontally healthy subjects based on different combinations of morphometric data related to maxillary front teeth and surrounding soft tissues. Patients with a thin-scalloped biotype are considered at risk because they have been associate...

    journal_title：Journal of clinical periodontology

    pub_type： 杂志文章

    doi：10.1111/j.1600-051X.2009.01479.x

    authors： Eghbali A,De Rouck T,De Bruyn H,Cosyn J

    更新日期：2009-11-01 00:00:00

  • Periodontal parameters around porous-coated dental implants after 3 to 4 years supporting overdentures.

    abstract：:In this study, an assessment using modified periodontal indices was done on a group of 48 fully edentulous patients who had each been treated with 3 porous-coated (EndoPore) dental implants and a mandibular overdenture. Parameters assessed included plaque index (PI), sulcular bleeding index (SBI), pocket probing depth...

    journal_title：Journal of clinical periodontology

    pub_type： 杂志文章

    doi：10.1111/j.1600-051x.1996.tb01819.x

    authors： Levy D,Deporter DA,Watson PA,Pilliar RM

    更新日期：1996-06-01 00:00:00

  • TNF-alpha TGF-beta2 and IL-1beta levels in gingival and peri-implant crevicular fluid before and after de novo plaque accumulation.

    abstract：AIMS:The aim of this split-mouth study was to investigate levels of tumour necrosis factor alpha (TNF-alpha), transforming growth factor beta (TGF-beta2) and interleukin-1 beta (IL-1beta) in gingival crevicular fluid (GCF) and peri-implant crevicular fluid (PICF) after a 21-day-period of de novo plaque accumulation in ...

    journal_title：Journal of clinical periodontology

    pub_type： 杂志文章

    doi：10.1111/j.1600-051X.2008.01224.x

    authors： Schierano G,Pejrone G,Brusco P,Trombetta A,Martinasso G,Preti G,Canuto RA

    更新日期：2008-06-01 00:00:00

  • Periodontal regeneration using a xenogeneic bone substitute seeded with autologous periodontal ligament-derived mesenchymal stem cells: A 12-month quasi-randomized controlled pilot clinical trial.

    abstract：AIM:To evaluate the safety and efficacy of autologous periodontal ligament-derived mesenchymal stem cells (PDL-MSCs) embedded in a xenogeneic bone substitute (XBS) for the regenerative treatment of intra-bony periodontal defects. MATERIAL AND METHODS:This quasi-randomized controlled pilot phase II clinical trial inclu...

    journal_title：Journal of clinical periodontology

    pub_type： 杂志文章

    doi：10.1111/jcpe.13368

    authors： Sánchez N,Fierravanti L,Núñez J,Vignoletti F,González-Zamora M,Santamaría S,Suárez-Sancho S,Fernández-Santos ME,Figuero E,Herrera D,García-Sanz JA,Sanz M

    更新日期：2020-11-01 00:00:00

  • Association between calcium channel blockers and gingival hyperplasia.

    abstract：AIM:To study the effect of the dose and type of calcium channel blockers (CCBs) on the risk of gingival hyperplasia and to quantify this association. METHODS:The study was conducted within the Integrated Primary Care Information Project in The Netherlands. A nested case-control study was designed within a cohort of al...

    journal_title：Journal of clinical periodontology

    pub_type： 杂志文章

    doi：10.1111/j.1600-051X.2010.01574.x

    authors： Kaur G,Verhamme KM,Dieleman JP,Vanrolleghem A,van Soest EM,Stricker BH,Sturkenboom MC

    更新日期：2010-07-01 00:00:00

  • Crevicular fluid glutathione levels in periodontitis and the effect of non-surgical therapy.

    abstract：AIM:To quantify reduced and oxidized glutathione (GSH and GSSG) levels in gingival crevicular fluid (GCF) of periodontitis patients pre-therapy (versus periodontally healthy controls) and ascertain whether successful non-surgical therapy alters glutathione levels. MATERIALS AND METHODS:Thirty-second GCF samples (6/sub...

    journal_title：Journal of clinical periodontology

    pub_type： 杂志文章

    doi：10.1111/j.1600-051X.2009.01504.x

    authors： Grant MM,Brock GR,Matthews JB,Chapple IL

    更新日期：2010-01-01 00:00:00

  • The prevalence of dentine hypersensitivity in general dental practice in the UK.

    abstract：AIM:The aim of this study was to establish the prevalence of dentine hypersensitivity in a cross-sectional study of patients visiting general dental practitioners in the South West region of the UK over a period of 1 calendar month. METHOD:Twelve dental practitioners examined 3593 patients over a period of 1 calendar ...

    journal_title：Journal of clinical periodontology

    pub_type： 杂志文章

    doi：10.1034/j.1600-051x.2000.027011860.x

    authors： Rees JS

    更新日期：2000-11-01 00:00:00

  • Does obesity influence the subgingival microbiota composition in periodontal health and disease?

    abstract：AIM:To evaluate whether obesity affects the subgingival microbial composition of patients with periodontal health or chronic periodontitis (CP). MATERIALS AND METHODS:Based on periodontal parameters, body mass index and waist-hip ratio, 166 patients were allocated into one of the following groups: Normal weight (NW) p...

    journal_title：Journal of clinical periodontology

    pub_type： 杂志文章

    doi：10.1111/jcpe.12634

    authors： Maciel SS,Feres M,Gonçalves TE,Zimmermann GS,da Silva HD,Figueiredo LC,Duarte PM

    更新日期：2016-12-01 00:00:00

  • Tooth survival and clinical outcomes up to 26 years after guided tissue regeneration therapy in deep intra-bony defects: Follow-up investigation of three randomized clinical trials.

    abstract：AIM:To investigate tooth survival and clinical long-term outcomes up to 26 years following guided tissue regeneration (GTR) therapy in deep intra-bony defects. METHODS:Patients from three prospective clinical split-mouth studies, which investigated the outcomes of GTR therapy, were re-evaluated 21-26 years after surge...

    journal_title：Journal of clinical periodontology

    pub_type： 杂志文章

    doi：10.1111/jcpe.13302

    authors： Cieplik F,Ihlenfeld I,Hiller KA,Pummer A,Schmalz G,Buchalla W,Christgau M

    更新日期：2020-07-01 00:00:00

  • The effect of electronic dental analgesia during sonic scaling.

    abstract：:The aim of the present study was to investigate the effects of electronic dental analgesia (EDA) during sonic scaling. The clinical trial included 30 healthy adult subjects and was conducted as a randomised single-blind split-mouth design. The applied procedure consisted of periodontal scaling by means of a sonic scal...

    journal_title：Journal of clinical periodontology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1111/j.1600-051x.1994.tb00794.x

    authors： Jacobs R,van Steenberghe D

    更新日期：1994-11-01 00:00:00

  • Patterns of bone loss around teeth restored with endodontic posts.

    abstract：OBJECTIVES:This retrospective study described the pattern of bone loss around teeth with endodontic posts in periodontitis patients, and compared it with contra-lateral teeth without posts. MATERIAL AND METHODS:From full-mouth radiographic surveys of 146 periodontitis patients (> or =35 years), 194 roots with endodont...

    journal_title：Journal of clinical periodontology

    pub_type： 杂志文章

    doi：10.1111/j.1600-051X.2009.01465.x

    authors： Katsamakis S,Timmerman M,Van der Velden U,de Cleen M,Van der Weijden F

    更新日期：2009-11-01 00:00:00

  • Kava-241 reduced periodontal destruction in a collagen antibody primed Porphyromonas gingivalis model of periodontitis.

    abstract：AIM:The aim of this study was to evaluate the effect of Kava-241, an optimized Piper methysticum Kava compound, on periodontal destruction in a collagen antibody primed oral gavage model of periodontitis. METHODS:Experimental periodontitis was induced by oral gavage of Porphyromonas gingivalis (P. gingivalis) + type I...

    journal_title：Journal of clinical periodontology

    pub_type： 杂志文章

    doi：10.1111/jcpe.12784

    authors： Alshammari A,Patel J,Al-Hashemi J,Cai B,Panek J,Huck O,Amar S

    更新日期：2017-11-01 00:00:00

  • Analysis of changes in gingival contour from three-dimensional co-ordinate data in subjects with drug-induced gingival overgrowth.

    abstract：OBJECTIVES:This aim of this study was to develop and assess a technique that could be used to assess accurately the gingival volume changes seen in drug-induced gingival overgrowth by the analysis of data obtained from an entire gingival surface by means of three-dimensional imaging. MATERIAL AND METHODS:Stone dental ...

    journal_title：Journal of clinical periodontology

    pub_type： 杂志文章

    doi：10.1111/j.1600-051X.2005.00769.x

    authors： Thomason JM,Ellis JS,Jovanovski V,Corson M,Lynch E,Seymour RA

    更新日期：2005-10-01 00:00:00

  • Cannabis use and destructive periodontal diseases among adolescents.

    abstract：AIM:The aim of this experiment was to investigate the association between cannabis use and destructive periodontal disease among adolescents. MATERIAL AND METHODS:Data from a population screening examination carried out among Chilean high school students from the Province of Santiago were used to determine whether the...

    journal_title：Journal of clinical periodontology

    pub_type： 杂志文章

    doi：10.1111/j.1600-051X.2008.01364.x

    authors： López R,Baelum V

    更新日期：2009-03-01 00:00:00

  • C-reactive protein in patients with coexistent periodontal disease and acute coronary syndromes.

    abstract：AIM:To evaluate periodontal disease (PD) influence on changes in high-sensitivity C-reactive protein (hsCRP) concentrations in patients with acute coronary syndromes and coexistent PD. MATERIALS AND METHODS:Dental examinations were carried out in a group of 50 consecutive patients, less than 60 years old, hospitalized...

    journal_title：Journal of clinical periodontology

    pub_type： 杂志文章

    doi：10.1111/j.1600-051X.2006.00931.x

    authors： Czerniuk MR,Górska R,Filipiak KJ,Opolski G

    更新日期：2006-06-01 00:00:00