Abstract：
BACKGROUND:A polymorphism in the promoter region of the transforming growth factor beta-1 (TGF-beta1) gene was described at position -509. This polymorphism represents a C-to-T base exchange, which creates a YY1 consensus sequence in an area involved with down transcription regulation. This polymorphism has been associated with risk for asthma and allergies. In this study we investigated the association between this polymorphism and chronic periodontitis severity. METHODS:Genomic DNA from oral mucosa of 87 Caucasian subjects was amplified by PCR, and digested with Eco81I restriction endonuclease. The alleles were separated by polyacrylamide gel electrophoresis. The differences in genotype distribution from those expected by Hardy-Weinberg equilibrium, and the significance of the differences in observed frequencies of the polymorphism in moderate and severe disease and healthy groups were assessed by the chi2 test. RESULTS:There was a difference in the presence of the different alleles and genotypes among the healthy, moderate and severe periodontitis groups. The allele T was seen at 57.7% in the group with severe periodontitis and 37.8% and 35.4% in the healthy group and moderate periodontitis group, respectively (p=0.0387). The genotype T/T was found at 38.5% in the group with severe periodontitis, and at a frequency of 8% in the healthy group (p=0.0258). CONCLUSION:These results demonstrate that the polymorphism at bp -509 in the TGF-beta1 promoter may have a small effect on the modulation of the inflammatory process during periodontitis.
journal_name
J Clin Periodontoljournal_title
Journal of clinical periodontologyauthors
de Souza AP,Trevilatto PC,Scarel-Caminaga RM,de Brito RB,Line SRdoi
10.1034/j.1600-051x.2003.00323.xkeywords:
subject
Has Abstractpub_date
2003-06-01 00:00:00pages
519-23issue
6eissn
0303-6979issn
1600-051Xpii
323journal_volume
30pub_type
杂志文章abstract：AIM AND BACKGROUND:The position of the most apical inter-dental portion of the alveolar crest is classically used in osseous resective surgery (ORS) to establish the amount of the inter-proximal and buccal/lingual bone resection. Supracrestal fibres connected to the root cementum are always present coronal to the alveo...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051X.2006.01027.x
更新日期：2007-02-01 00:00:00
abstract：BACKGROUND:Cross-arch bridges are used to stabilize teeth for patients with reduced periodontal support. Little is known about technical or biological complications, whether teeth and implants can be combined in this type of bridge and the long-term effects on tooth loss. MATERIALS AND METHODS:All patients treated in ...
journal_title：Journal of clinical periodontology
pub_type： 临床试验,杂志文章
doi：10.1111/j.1600-051X.2009.01528.x
更新日期：2010-03-01 00:00:00
abstract：:The aim of the present study was to characterize the eventual presence and molecular forms of gelatinase/type IV collagenase activities in gingival crevicular fluid (GCF) and saliva in different forms of periodontitis; patients with clinically healthy periodontium served as controls. Enzyme activities were monitored e...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051x.1994.tb00272.x
更新日期：1994-01-01 00:00:00
abstract：:The possible effects of ultrasonic scaling of all maxillary teeth for a total of 5 min on the inner ears of 20 healthy young adults, 22-36 years of age, were investigated by means of pure tone audiometry. Audiograms were obtained just before and immediatley after scaling. Temporary shifts in hearing threshold (TTS) of...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051x.1976.tb01858.x
更新日期：1976-05-01 00:00:00
abstract：:Periodontitis is generally considered to be a consequence of an unfavourable host-parasite interaction in which bacteria are the determinants of disease. An intense search continues for the bacteria, specific or non-specific, that are responsible for periodontitis and various forms of the periodontal diseases have bee...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章,评审
doi：10.1111/j.1600-051x.1995.tb00125.x
更新日期：1995-02-01 00:00:00
abstract：AIM:Inflammatory periodontal disease is widespread in dogs. This study evaluated site-specific changes in the canine gingival crevicular fluid (GCF) proteome during longitudinal progression from very mild gingivitis to mild periodontitis. Periodontitis diagnosis in dogs requires general anaesthesia with associated risk...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/jcpe.12548
更新日期：2016-07-01 00:00:00
abstract：AIM:Air-polishing devices (APDs) are highly effective in removing plaque and extrinsic staining. Their application on root surfaces, however, may result in clinically relevant substance removal, limiting the use in patients with periodontitis, where denuded root surfaces are frequently found. Therefore, the purpose of ...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1034/j.1600-051x.2003.300204.x
更新日期：2003-02-01 00:00:00
abstract：:Clinical healing following guided tissue regeneration (GTR) in deep intrabony pockets was compared to healing following gingival flap surgery alone (GFS). 15 patients received the GTR treatment including an expanded polytetrafluoroethylene membrane. 13 other patients received the control treatment GFS. A postsurgery p...
journal_title：Journal of clinical periodontology
pub_type： 临床试验,杂志文章
doi：10.1111/j.1600-051x.1996.tb01806.x
更新日期：1996-12-01 00:00:00
abstract：BACKGROUND AND AIMS:Periodontitis is an infection with an episodic nature of tissue support destruction. The aim of this work was to determine the levels of chemokines, cytokines, matrix metalloproteinase-13, periodontal pathogens and inflammatory cells in periodontal sites characterized by active periodontal connectiv...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051X.2007.01190.x
更新日期：2008-03-01 00:00:00
abstract：:It was the purpose of the present investigation to monitor the composition of the subgingival microbiota at selected sites in individuals passing through puberty and to correlate observed changes with the development of pubertal maturation. Between the ages of 11 and 14 years, pubertal and skeletal maturation was moni...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051x.1990.tb01054.x
更新日期：1990-11-01 00:00:00
abstract：AIM:The aim of the present study was to evaluate whether periodontitis is independently associated with oral health-related quality of life (OHRQoL) in individuals with end-stage renal disease (ESRD). MATERIALS AND METHODS:Calibrated examiners assessed 180 adults with ESRD. A full-mouth periodontal examination was per...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/jcpe.13233
更新日期：2020-03-01 00:00:00
abstract：:Sodium lauryl sulphate (SLS) is used in toothpaste and mouth rinses as an emulsifying and surface cleaning agent. SLS has been implicated in an increased incidence of oral irritation in subjects predisposed to recurrent aphthous stomatitis (RAU). Hence, the purpose of this study was to determine the levels of SLS foun...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051x.1997.tb00763.x
更新日期：1997-05-01 00:00:00
abstract：:The purpose of the study was to determine microscopically the %s of spirochetes at sites without periodontal destruction in subjects with destructive periodontal diseases (cases) and in subjects free of it (controls), who had not received professional prophylaxis. From a sample of 164 individuals aged between 30-44 ye...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051x.1995.tb00140.x
更新日期：1995-03-01 00:00:00
abstract：:One child and one adult with severe periodontitis were investigated for relevant systemic factors and predominant periodontal pocket bacteria. The child had a chronic neutropenia, the adult late yaws, a chronic iron deficiency and possibly rheumatoid arthritis. The predominant organisms in both pocket floras were gram...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051x.1983.tb02202.x
更新日期：1983-03-01 00:00:00
abstract：AIM:We aimed to investigate the association of periodontitis and oral hygiene indicators with changes in blood lipid parameters in a nationwide, population-based cohort in a longitudinal setting. MATERIALS AND METHODS:We included nationwide health screening program participants who underwent oral health examination in...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/jcpe.13373
更新日期：2020-12-01 00:00:00
abstract：:In a previous experimental gingivitis study, it was shown that in children with Down's syndrome (DS), gingival inflammation started earlier, was more extensive and developed faster, than in normal healthy control children. In both groups, the start of the process was accompanied by an acute inflammatory response and a...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051x.1988.tb01588.x
更新日期：1988-05-01 00:00:00
abstract：:The efficacy of a new toothbrush filament layout concept (Topix, Peridental, France) was compared to that of a standard vertical-tuft toothbrush. Bacterial and exogenous deposit elimination were used as parameters of efficacy. 30 dental surgery students took part in the study. Plaque index scores were calculated accor...
journal_title：Journal of clinical periodontology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1111/j.1600-051x.1994.tb00724.x
更新日期：1994-05-01 00:00:00
abstract：:Osseointegration or bony anchorage of oral implants was first described by Brånemark and coworkers. This type of connection between the titanium oxide layer and the bone gives stable long-term results for the implants in function. Fibrous tissue interphase between implant and bone will allow mobility which will gradua...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2710.1992.tb01226.x
更新日期：1990-08-01 00:00:00
abstract：:Acidified sodium chlorite (ASC) is recognised as a highly potent, broad spectrum antimicrobial system that has been successfully developed for uses in veterinary, food processing and medical device fields. The current studies aimed to investigate the persistence of antimicrobial action and plaque inhibitory properties...
journal_title：Journal of clinical periodontology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1111/j.1600-051x.1997.tb00236.x
更新日期：1997-09-01 00:00:00
abstract：:Previous research has shown that probing force and probe tine shape influence the clinically assessed probing depth. The purpose of the present study was to investigate the effect of tine shape and probing force on probe penetration, in relation to the microscopically assessed attachment level in untreated periodontal...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051x.1998.tb02465.x
更新日期：1998-05-01 00:00:00
abstract：AIM:The aim of this study was to assess the use of a micro-brush to remove plaque deposits from subgingival, periodontally involved root surfaces in vivo. METHODS:30 periodontally involved teeth requiring extraction for periodontal or prosthetic reasons in 26 adult patients were utilised. For inclusion, teeth had to d...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1034/j.1600-051x.2001.028009820.x
更新日期：2001-09-01 00:00:00
abstract：:The short-term response (3-4 months) to non-surgical periodontal treatment, i.e., oral hygiene instruction, scaling and root planing, was determined in 34 diabetic and 45 control subjects. Measurements of probing pocket depth and gingival bleeding (%) were used for evaluation. No significant difference could be observ...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051x.1991.tb01121.x
更新日期：1991-01-01 00:00:00
abstract：:The aim of this study was to monitor the presence of sulfate-reducing bacteria (SRB) at different sites in the mouths of both healthy individuals and periodontitis patients. In 20 healthy subjects and 21 periodontitis patients, samples were taken from the palate, vestibulum, dorsum of the tongue, supragingival plaque,...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1034/j.1600-051x.1999.260906.x
更新日期：1999-09-01 00:00:00
abstract：AIM:To develop an improved method for quantitative assessment of antimicrobial efficacy and substantivity of mouth rinses and dentifrices on in vivo treated plaque. MATERIAL AND METHODS:Nine- and 72-h-old plaques were formed in volunteers carrying out standardized hygiene using NaF-containing dentifrice. Plaques were ...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051X.2005.00859.x
更新日期：2006-01-01 00:00:00
abstract：BACKGROUND:The aim of this study was to retrospectively assess bone volumes, healed ridge topography and possibility to plan prosthetically guided implants (PGI) at least 6 months after extraction or exfoliation of first molars as a consequence of terminal periodontitis (EEFMP). MATERIALS AND METHODS:45 subjects with ...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/jcpe.13344
更新日期：2020-10-01 00:00:00
abstract：:True neoplasms are rarely localised to the periodontium. However, early recognition and diagnosis of neoplastic lesions resides within the realm of responsibility of the dentist. In recent years, a number of odontogenic tumors has been described characterized by an occurrence on the gingiva or in the intrabony part of...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章,评审
doi：10.1111/j.1600-051x.1996.tb00512.x
更新日期：1996-10-01 00:00:00
abstract：BACKGROUND, AIMS:This investigation was performed to assess longitudinal changes in periodontal bone height in an adult population over a period of 17 years. METHODS:In 1973, a random sample of 1000 individuals aged 3-70 years in the city of Jönköping, Sweden, was examined clinically and radiographically to assess den...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1034/j.1600-051x.2000.027009665.x
更新日期：2000-09-01 00:00:00
abstract：OBJECTIVE:To assess the efficacy of the novel ultrasonic Vector -system system for subgingival debridement and to compare the results with conventional periodontal instrumentation in vitro and in vivo. MATERIAL AND METHODS:Forty extracted human teeth were treated in vitro: Vector -system with polishing (VP) and abrasi...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章,随机对照试验
doi：10.1111/j.1600-051X.2006.00960.x
更新日期：2006-08-01 00:00:00
abstract：BACKGROUND:Subantimicrobial dose doxycycline (SDD--20 mg doxycycline twice daily) is indicated as an adjunctive treatment for periodontitis. Doxycycline downregulates the activity of matrix metalloproteinases (MMPs), key destructive enzymes in periodontal disease. Current understanding of periodontal pathogenesis sugge...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章,评审
doi：10.1111/j.1600-051X.2004.00558.x
更新日期：2004-09-01 00:00:00
abstract：:During a clinical trial for evaluating the antiplaque effect of two flavoured chlorhexidine rinses, the observation was made that bleeding after gentle massage of the gingival margin occurred more often after chemical than after mechanical oral hygiene measures. In order to ascertain the validity of this unexpected ob...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051x.1982.tb02100.x
更新日期：1982-07-01 00:00:00
