Abstract：
:It has been reported that the lipid soluble, anti-inflammatory drug triclosan, which is currently used in toothpastes and mouthrinses, may reduce pain. This may be an aspect of the anti-inflammatory effect of triclosan, which probably reduces the production of prostaglandin PGE2. However, triclosan may also exhibit a direct analgesic effect through an effect on excitable membranes. The aim of the present study was to examine the possible effect of triclosan on the nerve action potential, on the neuromuscular transmission and on the excitation-contraction coupling of skeletal muscle. Phrenic nerve-hemidiaphragm preparations, as well as isolated phrenic nerves, were dissected from Wistar albino rats and mounted by standard methods in Tyrode solution. Both during indirect and direct stimulation, the preparations were irreversibly inhibited by triclosan at concentrations higher than 5.0 x 10(-6)M. At low concentrations, the inhibition of the twitches during indirect stimulation and of the compound action potential was probably caused by a threshold increase for excitation of the phrenic nerve. At high concentrations, an additional inhibitory effect at the neuromuscular junction was disclosed. The directly stimulated preparation was also probably inhibited by an increase of the threshold for initiation of the muscle action potentials. In addition, a reduced KCl contracture and an acceleration of the caffeine contracture indicated an interaction with the sarcolemma. These results suggest that the analgesic effect of triclosan may be due to a direct interaction with excitable membranes.
journal_name
J Clin Periodontoljournal_title
Journal of clinical periodontologyauthors
Kjaerheim V,Röed A,Brodin P,Rölla Gdoi
10.1111/j.1600-051x.1995.tb00183.xsubject
Has Abstractpub_date
1995-06-01 00:00:00pages
488-93issue
6eissn
0303-6979issn
1600-051Xjournal_volume
22pub_type
杂志文章abstract：AIM:The aim of this experiment was to investigate the association between cannabis use and destructive periodontal disease among adolescents. MATERIAL AND METHODS:Data from a population screening examination carried out among Chilean high school students from the Province of Santiago were used to determine whether the...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051X.2008.01364.x
更新日期：2009-03-01 00:00:00
abstract：AIM:The purpose of this study was to determine inflammatory and epigenetic features following induction of oral and gut dysbiosis in experimental periodontitis in order to examine the interplay between oral and systemic infection. MATERIALS AND METHODS:Periodontitis was induced in 6- to 8-week-old C57BL/6 mice by (a) ...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/jcpe.13151
更新日期：2019-08-01 00:00:00
abstract：:A trial was conducted to compare the effectiveness of povidone iodine and chlorhexidine gluconate with buffered peroxyborate in the treatment of acute ulcerative gingivitis. After 20 patients had entered the trial and 11 had required additional therapy with metronidazole to control their symptoms, the study was termin...
journal_title：Journal of clinical periodontology
pub_type： 临床试验,杂志文章
doi：10.1111/j.1600-051x.1978.tb01919.x
更新日期：1978-11-01 00:00:00
abstract：:The purpose of this clinical trial was to compare the effectiveness and safety of a new dental flossing device (Quik Floss) to finger flossing in plaque removal, reduction of gingival inflammation and patient preference. 30 healthy, non-flossing adults with 20 natural teeth, a plaque index (PI) of at least 1.8 and a g...
journal_title：Journal of clinical periodontology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1111/j.1600-051x.1996.tb00626.x
更新日期：1996-09-01 00:00:00
abstract：AIM:We investigated the cross-sectional relationship between periodontal status and arterial stiffness, assessed through a novel Pulse Wave Imaging methodology. METHODS:Eighty volunteers were enrolled (39% male, age range 24-78 years) and 33 pairs were formed of periodontitis patients/periodontally healthy controls, m...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/jcpe.12717
更新日期：2017-05-01 00:00:00
abstract：BACKGROUND/AIMS:Smoking is a major risk factor for destructive periodontal disease. There is limited information with regard to effects of smoking in subjects with minimal periodontal destruction. The aim of the present investigation was to assess the development of gingival recession in young adult smokers and non-smo...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1034/j.1600-051x.2002.290207.x
更新日期：2002-02-01 00:00:00
abstract：:The purpose of this study was to assess the effect of rinsing and topical application of sanguinarine on labial surface plaque accumulation, compared with topically applied water, and compared with rinsing with chlorhexidine, while refraining from all oral hygiene measures for 5 days. Color photographs of the disclose...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051x.1988.tb01002.x
更新日期：1988-02-01 00:00:00
abstract：:Accelerated periodontal tissue destruction in patients with labile insulin-dependent diabetes mellitus (DM) and localized juvenile periodontitis (LJP) has been suggested to be related to functional abnormalities of neutrophils. We have recently found that collagenase in gingival crevicular fluid (GCF) of adult periodo...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051x.1992.tb00454.x
更新日期：1992-02-01 00:00:00
abstract：BACKGROUND AND PURPOSE:Periodontal maintenance is critical for the long-term success of prosthodontic treatment. This study investigates the validity of questionnaires/models in monitoring periodontitis for Chinese prosthodontic patients. METHODS:In total, 114 patients completed the questionnaire. The chi-squared test...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/jcpe.12103
更新日期：2013-06-01 00:00:00
abstract：OBJECTIVE:To compare the short-term performance of subgingival local delivery of 2% minocycline gel and conventional subgingival debridement in supportive periodontal therapy (SPT) patients. METHODS:Forty adult patients having completed active treatment for moderate to advanced chronic periodontitis were included in a...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章,随机对照试验
doi：10.1111/j.1600-051X.2005.00879.x
更新日期：2006-02-01 00:00:00
abstract：INTRODUCTION:Osteoporosis affects millions of elderly patients, and anti-resorptive drugs (ARD) such as bisphosphonates (BP) represent the first-line therapy. Despite the benefits related to the use of these medications, osteonecrosis of the jaw is a significant complication in a subset of patients receiving these drug...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/jcpe.12322
更新日期：2015-02-01 00:00:00
abstract：AIM:To investigate the prevalence of tetM, tetQ, nim and bla(TEM) antimicrobial resistance genes in subgingival and tongue samples of Greek subjects. MATERIALS AND METHODS:Fifty-four subjects participated in the present study. Participants each contributed with one pooled subgingival sample from the mesiobuccal surfac...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051X.2009.01425.x
更新日期：2009-07-01 00:00:00
abstract：AIMS:This paper reports the treatment of the periodontal component of the Papillon-Lefèvre syndrome in 2 siblings (case A, born 1974; case B, born 1976). METHOD:The initial treatment, in 1982, consisted of extraction of all primary teeth, scaling and rootplaning of the erupted permanent teeth and systemic antibiotic t...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1034/j.1600-051x.2000.027005354.x
更新日期：2000-05-01 00:00:00
abstract：AIM:To assess patient-reported outcome measures (PROMs), aesthetics and stability of root coverage procedures from a previous 6-month RCT after 1 year. MATERIAL & METHODS:Forty-five patients (90 recessions) had received a coronally advanced flap (CAF = control) only or a xenogeneic collagen matrix in addition (CAF + C...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章,随机对照试验
doi：10.1111/jcpe.12626
更新日期：2016-12-01 00:00:00
abstract：:Thirty-six subjects with no evidence of clinical gingival inflammation underwent a standardized toothbrushing procedure. Blood specimens, obtained from a vein in the antecubital fossa during the last 30 seconds of brushing, were cultured under aerobic and stringent anaerobic conditions. Three subjects exhibited detect...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051x.1979.tb02288.x
更新日期：1979-02-01 00:00:00
abstract：:Dehiscence depths were measured in vivo during surgical treatment of 113 teeth with gingival recession in 27 subjects. The average dehiscence depth determined was 5.43 mm with an average recession depth of 2.67 mm. Statistical evidence of a correlation between recession depth and dehiscence depth (average distance bet...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051x.1984.tb00911.x
更新日期：1984-10-01 00:00:00
abstract：BACKGROUND:Chlorhexidine (CHX) 0.2% solution, still the golden standard as mouthrinse for the prevention of plaque formation and development of gingivitis, has some limited side-effects such as extrinsic tooth staining, poor taste, taste disturbance, sensitivity changes in tongue, pain, and the content of alcohol. Thes...
journal_title：Journal of clinical periodontology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1034/j.1600-051x.2001.281207.x
更新日期：2001-12-01 00:00:00
abstract：:19 patients with a total of 23 periodontal lesions were selected for the study. Following flap-elevation, an occlusive membrane (Gore Tex) adjusted to the size and shape of the lesion was applied. The membrane was removed 4-6 weeks later by a 2nd operation. Clinical attachment levels were measured and intraoral radiog...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051x.1992.tb00641.x
更新日期：1992-03-01 00:00:00
abstract：:The present study used radiographic assessments to evaluate the pattern of destructive periodontal disease ina rural and an urban sample of 25-64 year old Greek adults. The rural sample (A) comprised 190 subjects and the urban sample (B) 400 subjects. 13% of the subjects in sample A and 8% in sample B were edentulous....
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051x.1995.tb00165.x
更新日期：1995-05-01 00:00:00
abstract：BACKGROUND:The aim of this randomized clinical trial was to evaluate the efficacy of Apically Positioned Flap with Fibre Retention Osseous Resective Surgery (FibReORS) or Osseous Resective Surgery (ORS) to treat periodontal pockets associated with infrabony defect ≤3 mm at posterior natural teeth. MATERIAL AND METHODS...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章,随机对照试验
doi：10.1111/jcpe.12042
更新日期：2013-02-01 00:00:00
abstract：OBJECTIVES:Removal of dental plaque is an essential element of periodontal treatment. However, there have also been studies of the effects of the mechanical stimulation provided by toothbrushing on gingival host-defense mechanisms. The aim of the study was to evaluate the effects of toothbrushing on gingival fibroblast...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1034/j.1600-051x.2002.290901.x
更新日期：2002-09-01 00:00:00
abstract：OBJECTIVES:Evaluation of the clinical effect of topical subgingival application of doxycycline gel adjunctively to scaling and root planing (SRP) at furcation sites during supportive periodontal therapy (SPT). MATERIAL AND METHODS:In 39 SPT patients exhibiting at least four pockets > or m with bleeding on probing, SRP...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章,随机对照试验
doi：10.1111/j.1600-051X.2009.01414.x
更新日期：2009-06-01 00:00:00
abstract：OBJECTIVES:The aim of the present study was to compare the combination therapy of deep intrabony periodontal defects using an Er:YAG laser (ERL) and enamel matrix protein derivative (EMD) to scaling and root planing+ ethylenediaminetetraacetic acid (EDTA)+EMD. MATERIAL AND METHODS:Twenty-two patients with chronic peri...
journal_title：Journal of clinical periodontology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1034/j.1600-051x.2003.00412.x
更新日期：2003-11-01 00:00:00
abstract：:Some triclosan and stannous fluoride toothpastes have been shown effective in reducing plaque and more particularly gingivitis in home use studies. There have been few comparisons of such products for their chemical plaque inhibitory action divorced from the indeterminate variable of toothbrushing. This study was a ra...
journal_title：Journal of clinical periodontology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1111/j.1600-051x.1997.tb00486.x
更新日期：1997-03-01 00:00:00
abstract：:Individual sites with gain and loss of probing attachment were identified amongst 1688 proximal sites in non-molar teeth from 49 patients monitored for 24 months following oral hygiene instruction and root debridement. The distribution of sites with gain and loss of probing attachment was studied within each of the 49...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051x.1987.tb01548.x
更新日期：1987-08-01 00:00:00
abstract：AIM:There is a paucity of up-to-date data regarding prevalence and risk indicators of periodontitis in Italy. Therefore, the aim of this study was to evaluate the prevalence of periodontitis and its risk indicators among adults from an urban area in North Italy. MATERIAL AND METHODS:This cross-sectional survey used a ...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/jcpe.12420
更新日期：2015-07-01 00:00:00
abstract：:The purpose of the study was to examine the relationship between spacing and dental health in 15-year-old adolescents. The whole sample consisted of 156 subjects. Out of them, 74 females and 73 males with 6 anterior teeth made up the study group for examination of the upper jaw. 75 females and 75 males had 6 anterior ...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051x.1984.tb01337.x
更新日期：1984-07-01 00:00:00
abstract：AIM:This case-control study investigates the relationship of stress and anxiety with periodontal clinical characteristics. METHOD:Seventy-nine selected patients (mean age 46.8+/-8 years) were assigned to three groups in accordance with their levels of probing pocket depth (PPD): control group (PPD< or =3 mm, n=22), te...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1034/j.1600-051x.2003.10271.x
更新日期：2003-05-01 00:00:00
abstract：:Vestibuloplasties with free gingival grafts were performed on 42 teeth in 12 patients exhibiting gingival recession. The tendency toward recurrence was studied after postoperative intervals of 1, 6 and 12 months. The extensions (vestibuloplasties), which were always wider than the transplant, recurred up to the transp...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051x.1975.tb01730.x
更新日期：1975-04-01 00:00:00
abstract：:This study compared oral irrigation and rinsing with chlorhexidine (CHX) and placebo in the treatment of naturally occurring chronic gingivitis. 44 subjects with at least 6 interproximal sites which bled on probing were randomly distributed on a double-blind basis into 4 treatment groups, placebo-rinse, CHX-rinse (0.1...
journal_title：Journal of clinical periodontology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1990-09-01 00:00:00
