Abstract:
AIM:To systematically review the evidence regarding immune senescence in the pathogenesis of periodontitis and dental caries. METHODS:A systematic search of electronic databases utilizing medical subject headings (MeSH terms) supplemented by screening of review articles and other relevant texts was undertaken. RESULTS:Seventy-three articles were included (43 for periodontitis, 30 for caries). Study results were found to be generally heterogeneous. Regarding periodontitis, human studies suggest evidence for altered neutrophil function and increased production of pro-inflammatory mediators (e.g. interleukin-1β, interleukin-6 and prostaglandin E2 ) in older compared to younger subjects, and animal experiments suggest increased expression of genes that contribute to a pro-inflammatory state in older compared to younger animals. Regarding dental caries, research relating to changes in immune functioning and the impact of ageing is in its infancy. A small number of studies have reported components of innate and adaptive immunity that affect the composition of saliva and dental biofilms with possible impacts on caries progression. CONCLUSION:There is evidence that immune functioning related to periodontitis and (less investigated) dental caries alters with increasing age. In both conditions, age-associated mechanistic changes in immune functioning are complex and incompletely understood and it is not clear how these relate to disease susceptibility.
journal_name
J Clin Periodontoljournal_title
Journal of clinical periodontologyauthors
Preshaw PM,Henne K,Taylor JJ,Valentine RA,Conrads Gdoi
10.1111/jcpe.12675subject
Has Abstractpub_date
2017-03-01 00:00:00pages
S153-S177eissn
0303-6979issn
1600-051Xjournal_volume
44 Suppl 18pub_type
杂志文章,评审abstract:AIM:The purpose of this retrospective case series study was to evaluate the usefulness and performance of a comprehensive approach to assigning periodontal prognosis by assessing the risk of tooth loss due to periodontal disease (TLPD) and estimate the survival time (ST) of periodontally compromised teeth (PCT). MATER...
journal_title:Journal of clinical periodontology
pub_type:
doi:10.1111/jcpe.12857
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND, AIMS:The form of the molar roots and their furcated region influence both the pathogenesis of periodontal destruction and therapeutic attempts. METHOD:Using a specially-constructed measuring device, 359 1st and 2nd molars, both upper and lower, were analysed 3-dimensionally. The parameters measured were ho...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1034/j.1600-051x.2000.027012926.x
更新日期:2000-12-01 00:00:00
abstract::This paper presents the combined use of decision trees and cost-effectiveness analysis to determine on which patients new diagnostic tests can be useful, and whether they can change the dentist's decision to provide different services and thus improve patient outcomes in 5 different categories of patients. A decision ...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1111/j.1600-051x.1996.tb02089.x
更新日期:1996-03-01 00:00:00
abstract:BACKGROUND:Aim of this systematic review (SR) of randomized controlled trials (RCTs) was to evaluate effect of different flap designs and graft materials for root coverage, in terms of aesthetics, patient satisfaction and self-reported morbidity (post-operative pain/discomfort). MATERIAL AND METHODS:A comprehensive li...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章,评审
doi:10.1111/jcpe.13346
更新日期:2020-11-01 00:00:00
abstract::This paper summarizes the rationale for the application of microbiology in the management of destructive periodontal diseases. The subgingival microbiota in patients with severe periodontitis is complex and contains high numbers of obligate anaerobic bacteria as well as facultative micro-organisms. It has become clear...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章,评审
doi:10.1111/j.1600-051x.1991.tb02308.x
更新日期:1991-07-01 00:00:00
abstract::The purpose of this study was to investigate the validity and reproducibility of an oral rating index (ORI) as a conceptual measurement of "gingival health care" level in adults. The study was conducted on 163 patients who received medical examinations and attended for dental checkups at a hospital. The score of the O...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1034/j.1600-051x.2000.027006411.x
更新日期:2000-06-01 00:00:00
abstract:AIM:To develop an improved method for quantitative assessment of antimicrobial efficacy and substantivity of mouth rinses and dentifrices on in vivo treated plaque. MATERIAL AND METHODS:Nine- and 72-h-old plaques were formed in volunteers carrying out standardized hygiene using NaF-containing dentifrice. Plaques were ...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1111/j.1600-051X.2005.00859.x
更新日期:2006-01-01 00:00:00
abstract:AIM:The aim of this study was to determine the prospective association between sex steroid concentrations with periodontal progression and incident tooth loss in men and women. METHODS:We used data from 1465 women and 1838 men (age 20-81 years) with completed five-year-follow-up from the Study-of-Health-in-Pomerania, ...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1111/jcpe.12493
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Although a growing body of evidence indicates that oral irrigation with water has therapeutic benefits in periodontitis, the mechanisms of action have not been elucidated. The aims of this study were: (1) to analyze the effects of oral irrigation (Water Pik Oral Irrigator) on the clinical signs of adult peri...
journal_title:Journal of clinical periodontology
pub_type: 临床试验,杂志文章
doi:10.1034/j.1600-051x.2000.027002134.x
更新日期:2000-02-01 00:00:00
abstract::In a study of the efficacy of modified Widman flap surgery and scaling and root planning accompanied by 1 of 4 systemic adjunctive agents, Augmentin, tetracycline, ibuprofen or placebo, it was observed that subjects differed in their response to therapy. The difference was only partially accounted for by the adjunctiv...
journal_title:Journal of clinical periodontology
pub_type: 临床试验,杂志文章
doi:10.1111/j.1600-051x.1995.tb00816.x
更新日期:1995-08-01 00:00:00
abstract::This study examined age relationships and mutual interrelationships between cultivable Actinobacillus actinomycetemcomitans and Bacteroides intermedius in 1624 periodontitis patients, 15 to 89 years of age. Each subject contributed a pooled subgingival sample, obtained from 3 deep periodontal pockets with paper points...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:
更新日期:1990-10-01 00:00:00
abstract::The aim of the present study was to examine the Actinobacillus actinomycetemcomitans carrier rate in Chinese subjects, and to determine serotype distribution, presence of the leukotoxin gene lktA and the structure of the lktA-promoter region. Subgingival microbiological samples were obtained from 31 Chinese subjects w...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1034/j.1600-051x.1999.260803.x
更新日期:1999-08-01 00:00:00
abstract:AIM:To compare the effect of oral infection with Porphyromonas gingivalis or Fusobacterium nucleatum versus infection with both bacteria on mouse periodontal tissues, and to characterize the inflammatory response. MATERIALS AND METHODS:Mice were orally infected with P. gingivalis, F. nucleatum or both. At 42 days post...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1111/j.1600-051X.2009.01393.x
更新日期:2009-05-01 00:00:00
abstract:OBJECTIVES:To explore the subgingival periodontal microflora in a Saudi Arabian population with a special focus on its relationship with various smoking habits. MATERIAL AND METHODS:A total of 198 individuals in the age range 17-60 years were included in the study. 29% were water-pipe smokers, 18% cigarette smokers, 1...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1111/j.1600-051X.2005.00710.x
更新日期:2005-06-01 00:00:00
abstract:OBJECTIVES:To determine the plaque-removing ability of a Sonicare Plus electric toothbrush in an in vitro model. MATERIAL AND METHODS:Multispecies oral biofilms derived from human saliva were grown on hydroxyapatite discs in a constant-depth film fermenter. The biofilms were placed in a typodont model so that they mim...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1034/j.1600-051x.2003.00307.x
更新日期:2003-07-01 00:00:00
abstract::The polymorphonuclear neutrophil (PMN) appears to be an important cell in the protection of the host from pathogenic periodontal microorganisms and, despite some reports to the contrary, it is generally assumed that early-onset forms of periodontal disease (including both juvenile and rapidly progressing periodontitis...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1111/j.1600-051x.1994.tb00300.x
更新日期:1994-03-01 00:00:00
abstract:BACKGROUND:The hypothesis was tested that bacterial susceptibilities in aggressive periodontitis change upon administration of systemic antibiotics as adjuncts to periodontal therapy. METHODS:In 23 subjects (average age 38.9+/-6.7 years) with aggressive periodontitis, microbial parameters were assessed prior to and 1 ...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1034/j.1600-051x.2003.10196.x
更新日期:2003-03-01 00:00:00
abstract:BACKGROUND:Tobacco smoking is an accepted risk factor for periodontal disease. Most studies in the periodontal literature rely on reported smoking habits which can be unreliable. This review specifically addresses this problem. METHODS:Methods of assessing tobacco smoke exposure, variation in individual smoking habits...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章,评审
doi:10.1034/j.1600-051x.2001.280801.x
更新日期:2001-08-01 00:00:00
abstract::The purpose of this study was to evaluate the sensitivity of 4 clinical techniques used in detecting early plaque during a period of dietary sucrose restriction and during a period of sucrose supplementation. The accumulation of plaque during experimental periods of 3 h, 6 h and 18 h was recorded in a group of 38 dent...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1111/j.1600-051x.1986.tb00862.x
更新日期:1986-08-01 00:00:00
abstract:OBJECTIVE:To assess the efficacy of the novel ultrasonic Vector -system system for subgingival debridement and to compare the results with conventional periodontal instrumentation in vitro and in vivo. MATERIAL AND METHODS:Forty extracted human teeth were treated in vitro: Vector -system with polishing (VP) and abrasi...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1600-051X.2006.00960.x
更新日期:2006-08-01 00:00:00
abstract:OBJECTIVES:The aim of this clinical study was to intra-individually compare Class V restorations of a calcium aluminate cement (CAC), resin composite and enamel with respect to the adjacent levels of interleukin (IL)-1alpha, IL-1beta and IL-1 receptor antagonist (IL-1ra) in gingival crevicular fluid (GCF). The hypothes...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1111/j.1600-051X.2005.00698.x
更新日期:2005-05-01 00:00:00
abstract::The concept of locally delivering chemotherapeutic agents to the periodontal pocket as a method to treat periodontal disease has been studied for over 20 years. A number of locally delivered chemotherapeutic agents in periodontal therapy are either currently available or under investigation. Clinical efficacy derives ...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1111/j.1600-051x.1998.tb02395.x
更新日期:1998-11-01 00:00:00
abstract:BACKGROUND:Current interest in the assessment of probing attachment level measurements has been stimulated by recent introduction of novel periodontal probes as well as by the reclassification of periodontal diseases. Clinical attachment level (CAL) is currently the "gold standard" for diagnosing and monitoring periodo...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1111/j.0303-6979.2004.00464.x
更新日期:2004-03-01 00:00:00
abstract:AIM:The study was set to evaluate the validity of subjective jaw bone quality assessment. MATERIALS AND METHODS:A total of 298 patients (198 females, mean age 56.4) were treated with oral implants at the Periodontology Department at the University Hospital of KUL. A total of 761 TiUnite implants have been installed. S...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1111/j.1600-051X.2007.01047.x
更新日期:2007-04-01 00:00:00
abstract::This report will focus attention on the diagnostic and therapeutic difficulties involved in a patient who presented with a gingival papillary-verrucous lesion, which subsequently developed into a squamous cell carcinoma. ...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1111/j.1600-051x.1987.tb01515.x
更新日期:1987-01-01 00:00:00
abstract:AIM:A recent cluster analysis has identified three gingival biotypes among 100 periodontally healthy subjects based on different combinations of morphometric data related to maxillary front teeth and surrounding soft tissues. Patients with a thin-scalloped biotype are considered at risk because they have been associate...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1111/j.1600-051X.2009.01479.x
更新日期:2009-11-01 00:00:00
abstract::Osseointegration or bony anchorage of oral implants was first described by Brånemark and coworkers. This type of connection between the titanium oxide layer and the bone gives stable long-term results for the implants in function. Fibrous tissue interphase between implant and bone will allow mobility which will gradua...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2710.1992.tb01226.x
更新日期:1990-08-01 00:00:00
abstract:OBJECTIVES:Increased levels of reactive oxygen species lead to oxidative stress. Recent data suggest increased lipid peroxidation (LPO) levels and oxidative stress in periodontitis. Malondialdehyde (MDA), a significant LPO product, increases in oxidative stress. In this study, MDA levels and total oxidant status (TOS) ...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1111/j.1600-051X.2007.01091.x
更新日期:2007-07-01 00:00:00
abstract:BACKGROUND:The aim of this randomized controlled clinical trial was to determine the effects of single-visit full-mouth ultrasonic debridement versus quadrant-wise therapy. MATERIAL AND METHODS:Thirty-six subjects with chronic periodontitis, were randomly allocated to three groups--quadrant-wise ultrasonic debridement...
journal_title:Journal of clinical periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1600-051X.2005.00775.x
更新日期:2005-07-01 00:00:00
abstract:OBJECTIVES:The aim of the present study was to compare the combination therapy of deep intrabony periodontal defects using an Er:YAG laser (ERL) and enamel matrix protein derivative (EMD) to scaling and root planing+ ethylenediaminetetraacetic acid (EDTA)+EMD. MATERIAL AND METHODS:Twenty-two patients with chronic peri...
journal_title:Journal of clinical periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1034/j.1600-051x.2003.00412.x
更新日期:2003-11-01 00:00:00