Tooth survival and clinical outcomes up to 26 years after guided tissue regeneration therapy in deep intra-bony defects: Follow-up investigation of three randomized clinical trials.

Abstract:

AIM:To investigate tooth survival and clinical long-term outcomes up to 26 years following guided tissue regeneration (GTR) therapy in deep intra-bony defects. METHODS:Patients from three prospective clinical split-mouth studies, which investigated the outcomes of GTR therapy, were re-evaluated 21-26 years after surgery independent of the membrane type used, and tooth survival was assessed according to several site-specific and patient-related factors. RESULTS:About 50 patients contributing 102 defects were available for this long-term follow-up. After up to 26 years (median 23.3 years), 52.9% of the teeth were still in situ. The median survival of the extracted teeth was 13.8 years. Patients with diabetes mellitus and/or smoking history lost significantly more teeth in the long term. Compared to the 1-year situation, there was no new median CAL loss after up to 26 years in the teeth which were still in situ. CONCLUSIONS:Within the limitations of this study, our data show that more than 50% of the initially seriously diseased teeth were still in situ up to 26 years following GTR therapy despite an overall limited adherence to SPT. In the majority of these teeth, the CAL gain 1 year after GTR could be maintained over this long period.

journal_name

J Clin Periodontol

authors

Cieplik F,Ihlenfeld I,Hiller KA,Pummer A,Schmalz G,Buchalla W,Christgau M

doi

10.1111/jcpe.13302

subject

Has Abstract

pub_date

2020-07-01 00:00:00

pages

863-874

issue

7

eissn

0303-6979

issn

1600-051X

journal_volume

47

pub_type

杂志文章
  • Periodontitis and systemic diseases: a record of discussions of working group 4 of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases.

    abstract:BACKGROUND:There has been an explosion in research into possible associations between periodontitis and various systemic diseases and conditions. AIM:To review the evidence for associations between periodontitis and various systemic diseases and conditions, including chronic obstructive pulmonary disease (COPD), pneum...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章

    doi:10.1111/jcpe.12091

    authors: Linden GJ,Herzberg MC,Working group 4 of joint EFP\/AAP workshop.

    更新日期:2013-04-01 00:00:00

  • Clinical benefits of ridge preservation for implant placement compared to natural healing in maxillary teeth: A retrospective study.

    abstract:AIM:The purpose of this retrospective study was to determine clinical benefits of ridge preservation in terms of surgical invasiveness of implant placement compared to natural healing in the maxilla. MATERIALS & METHODS:This study included 178 patients with 206 implants placed at ridge-preserved sites and 493 patients...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章

    doi:10.1111/jcpe.13231

    authors: Park SH,Song YW,Sanz-Martín I,Cha JK,Lee JS,Jung UW

    更新日期:2020-03-01 00:00:00

  • Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.

    abstract::A new periodontitis classification scheme has been adopted, in which forms of the disease previously recognized as "chronic" or "aggressive" are now grouped under a single category ("periodontitis") and are further characterized based on a multi-dimensional staging and grading system. Staging is largely dependent upon...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章

    doi:10.1111/jcpe.12946

    authors: Papapanou PN,Sanz M,Buduneli N,Dietrich T,Feres M,Fine DH,Flemmig TF,Garcia R,Giannobile WV,Graziani F,Greenwell H,Herrera D,Kao RT,Kebschull M,Kinane DF,Kirkwood KL,Kocher T,Kornman KS,Kumar PS,Loos BG,Machtei E

    更新日期:2018-06-01 00:00:00

  • Comparison of new and 3-month-old toothbrushes in plaque removal.

    abstract:OBJECTIVES:It is often recommended that manual toothbrushes should be replaced every 3 months. The aim of this study was to compare the effectiveness of new and 3-month-old toothbrushes in the removal of dental plaque. MATERIALS AND METHODS:A single examiner blind, randomized study was performed in which 40 adult pati...

    journal_title:Journal of clinical periodontology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1034/j.1600-051x.2002.290709.x

    authors: Tan E,Daly C

    更新日期:2002-07-01 00:00:00

  • Interleukin-1 gene polymorphism and periodontal status. A case-control study.

    abstract:OBJECTIVES:This case-control study examined polymorphisms at the interleukin-1 gene in relation to periodontal status, subgingival bacteria and systemic antibodies to periodontal microbiota. METHODS:132 periodontitis patients were age- and gender-matched with 73 periodontally intact controls. Full-mouth clinical asses...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章

    doi:10.1034/j.1600-051x.2001.028005389.x

    authors: Papapanou PN,Neiderud AM,Sandros J,Dahlén G

    更新日期:2001-05-01 00:00:00

  • The role of RgpA in the pathogenicity of Porphyromonas gingivalis in the murine periodontitis model.

    abstract:AIM:To investigate the in vivo role of gingipains in Porphyromonas gingivalis' virulence, and suggest a possible host mechanisms through which the bacteria cause alveolar bone loss. MATERIALS AND METHODS:Mice were orally infected with P. gingivalis wild type, or the gingipains mutants (RgpA⁻, Kgp⁻, RgpA⁻/Kgp⁻). Mice w...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章

    doi:10.1111/jcpe.12139

    authors: Wilensky A,Polak D,Houri-Haddad Y,Shapira L

    更新日期:2013-10-01 00:00:00

  • Irrigation with chlorhexidine to resolve naturally occurring gingivitis. A methodologic study.

    abstract::This study compared oral irrigation and rinsing with chlorhexidine (CHX) and placebo in the treatment of naturally occurring chronic gingivitis. 44 subjects with at least 6 interproximal sites which bled on probing were randomly distributed on a double-blind basis into 4 treatment groups, placebo-rinse, CHX-rinse (0.1...

    journal_title:Journal of clinical periodontology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Brownstein CN,Briggs SD,Schweitzer KL,Briner WW,Kornman KS

    更新日期:1990-09-01 00:00:00

  • Relationship between clinical parameters and cytokine profiles in inflamed gingival tissue and serum samples from patients with chronic periodontitis.

    abstract:OBJECTIVE:The purpose of the present study was to assess the relation between clinical parameters and concentrations of the key (IL-1beta, TNF-alpha, IL-2, IFN-gamma, IL-4, IL-10) cytokines, important in the initiation and progression of periodontal diseases, within inflamed gingival tissues and serum samples from pati...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章

    doi:10.1046/j.0303-6979.2003.00425.x

    authors: Górska R,Gregorek H,Kowalski J,Laskus-Perendyk A,Syczewska M,Madaliński K

    更新日期:2003-12-01 00:00:00

  • Psychosocial stress, lifestyle and periodontal health.

    abstract:BACKGROUND, AIMS:The hypothesis that psychosocial stress and lifestyle are related to periodontal status was tested. MATERIAL AND METHODS:The study was performed in 1997-98 in 10 areas in Lithuania (response rate 53%). Information comprised recordings of oral hygiene, calculated levels of remaining periodontal support...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章

    doi:10.1034/j.1600-051x.2002.290408.x

    authors: Aleksejuniené J,Holst D,Eriksen HM,Gjermo P

    更新日期:2002-04-01 00:00:00

  • The prevalence of dentine hypersensitivity in general dental practice in the UK.

    abstract:AIM:The aim of this study was to establish the prevalence of dentine hypersensitivity in a cross-sectional study of patients visiting general dental practitioners in the South West region of the UK over a period of 1 calendar month. METHOD:Twelve dental practitioners examined 3593 patients over a period of 1 calendar ...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章

    doi:10.1034/j.1600-051x.2000.027011860.x

    authors: Rees JS

    更新日期:2000-11-01 00:00:00

  • Antagonists of Wnt/β-catenin signalling in the periodontitis associated with type 2 diabetes and smoking.

    abstract:AIM:This study evaluated the levels of sclerostin (SOST) and Dickkopf (DKK)-1 in the chronic periodontitis (CP) associated with type 2 diabetes (DM) and/or smoking. Relationships between SOST, DDK1, RANKL, OPG, IL-1ß, IL-6 and TNF-α, and pathogens were assessed. MATERIAL AND METHODS:The study population included non-d...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章

    doi:10.1111/jcpe.12854

    authors: Miranda TS,Napimoga MH,Feres M,Marins LM,da Cruz DF,da Silva HDP,Duarte PM

    更新日期:2018-03-01 00:00:00

  • Serum IgG2 level, Gm(23) allotype and FcgammaRIIa and FcgammaRIIIb receptors in refractory periodontal disease.

    abstract::The purpose of this investigation was to compare the levels of serum IgG2, the frequency of detection of Gm(23)-negative allotype and frequency of detection of FcgammaRIIa and FcgammaRIIIb receptor haplotypes in 32 refractory, 54 successfully treated and 27 periodontally healthy individuals. Refractory subjects showed...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章

    doi:10.1111/j.1600-051x.1998.tb02475.x

    authors: Colombo AP,Eftimiadi C,Haffajee AD,Cugini MA,Socransky SS

    更新日期:1998-06-01 00:00:00

  • Multiple forms of gelatinases/type IV collagenases in saliva and gingival crevicular fluid of periodontitis patients.

    abstract::The aim of the present study was to characterize the eventual presence and molecular forms of gelatinase/type IV collagenase activities in gingival crevicular fluid (GCF) and saliva in different forms of periodontitis; patients with clinically healthy periodontium served as controls. Enzyme activities were monitored e...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章

    doi:10.1111/j.1600-051x.1994.tb00272.x

    authors: Ingman T,Sorsa T,Lindy O,Koski H,Konttinen YT

    更新日期:1994-01-01 00:00:00

  • Serum IgA and IgG antibodies to Treponema vincentii and Treponema denticola in adult periodontitis, juvenile periodontitis and periodontally healthy subjects.

    abstract::13 patients with untreated adult periodontitis (AP) were compared to 8 subjects free of periodontal disease (H) with respect to plaque index (PlI), gingival index (GI), probing depth (PD) and differential counts of subgingival bacterial morphotypes from a pooled sample of 6 surfaces with the greatest probing depth. Se...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章

    doi:10.1111/j.1600-051x.1986.tb00878.x

    authors: Lai CH,Listgarten MA,Evian CI,Dougherty P

    更新日期:1986-09-01 00:00:00

  • Association of periodontal disease to anxiety and depression symptoms, and psychosocial stress factors.

    abstract:OBJECTIVE:A cross-sectional study was conducted to investigate if anxiety, depression and hopelessness symptoms are associated with periodontal disease. METHOD:A total of 160 subjects took part in this study. Probing depth and clinical attachment level were recorded at six sites per tooth and the gingival and plaque i...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章

    doi:10.1111/j.1600-051X.2004.00538.x

    authors: Solis AC,Lotufo RF,Pannuti CM,Brunheiro EC,Marques AH,Lotufo-Neto F

    更新日期:2004-08-01 00:00:00

  • Host response to microbial challenge following resective/non-resective periodontal therapy.

    abstract:BACKGROUND:The host response to microbial challenge depends on the recruitment of homing leucocytes and may be related to the experience to infectious insults over years. PURPOSE:The aim of this study was to investigate the soft tissue reactions to de novo plaque formation at sites treated with either open flap debrid...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1600-051X.2005.00746.x

    authors: Zitzmann NU,Lindhe J,Berglundh T

    更新日期:2005-11-01 00:00:00

  • The relationship of stress and anxiety with chronic periodontitis.

    abstract:AIM:This case-control study investigates the relationship of stress and anxiety with periodontal clinical characteristics. METHOD:Seventy-nine selected patients (mean age 46.8+/-8 years) were assigned to three groups in accordance with their levels of probing pocket depth (PPD): control group (PPD< or =3 mm, n=22), te...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章

    doi:10.1034/j.1600-051x.2003.10271.x

    authors: Vettore MV,Leão AT,Monteiro Da Silva AM,Quintanilha RS,Lamarca GA

    更新日期:2003-05-01 00:00:00

  • Dose response of chlorhexidine against plaque and comparison with triclosan.

    abstract::The optimum dose of chlorhexidine delivered by mouthrinse, which balances efficacy against local side-effects, is generally considered to be in the region of 20 mg 2 x daily. Unfortunately, there have been few dose-response studies for chlorhexidine mouthrinses and for these, only limited details are published. The ai...

    journal_title:Journal of clinical periodontology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1600-051x.1994.tb00313.x

    authors: Jenkins S,Addy M,Newcombe RG

    更新日期:1994-04-01 00:00:00

  • Tooth loss after active periodontal therapy. 1: patient-related factors for risk, prognosis, and quality of outcome.

    abstract:OBJECTIVES:Assessment of patient-related factors contributing (1) to tooth loss and (2) to the quality of treatment outcome 10 years after initiation of anti-infective therapy. MATERIAL AND METHODS:All patients who had received active periodontal treatment 10 years ago by the same examiner were recruited consecutively...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章

    doi:10.1111/j.1600-051X.2007.01184.x

    authors: Eickholz P,Kaltschmitt J,Berbig J,Reitmeir P,Pretzl B

    更新日期:2008-02-01 00:00:00

  • Cost effectiveness of periodontal services.

    abstract::This paper presents the combined use of decision trees and cost-effectiveness analysis to determine on which patients new diagnostic tests can be useful, and whether they can change the dentist's decision to provide different services and thus improve patient outcomes in 5 different categories of patients. A decision ...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章

    doi:10.1111/j.1600-051x.1996.tb02089.x

    authors: Douglass CW,Fox CH

    更新日期:1996-03-01 00:00:00

  • Periodontal therapy by local delivery of tetracycline.

    abstract::The present investigation assessed the feasibility of treating periodontal disease by controlled delivery of antibacterial agents from within periodontal pockets. Tetracycline-filled hollow fibers placed in the gingival sulcus were shown to have a dramatic effect both on the periodontal microflora and clinical manifes...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章

    doi:10.1111/j.1600-051x.1979.tb02186.x

    authors: Goodson JM,Haffajee A,Socransky SS

    更新日期:1979-04-01 00:00:00

  • Change in subgingival microbial profiles in adult periodontitis subjects receiving either systemically-administered amoxicillin or metronidazole.

    abstract:AIM:The current investigation evaluated changes in levels and proportions of 40 bacterial species in subgingival plaque samples during, immediately after and up to 1 year after metronidazole or amoxicillin therapy combined with SRP. METHOD:After baseline clinical and microbiological monitoring, 17 adult periodontitis ...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章

    doi:10.1034/j.1600-051x.2001.028007597.x

    authors: Feres M,Haffajee AD,Allard K,Som S,Socransky SS

    更新日期:2001-07-01 00:00:00

  • Particulate bioglass as a grafting material in the treatment of periodontal intrabony defects.

    abstract::The present clinical trial was designed to evaluate the effects of a bioactive glass, Perioglas, in the treatment of periodontal intrabony defects. 20 patients, 23-55 years of age (44 sites), with intrabony defects completed the 1-year study. Teeth with furcation involvement were excluded. After completion of initial ...

    journal_title:Journal of clinical periodontology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1600-051x.1997.tb00205.x

    authors: Zamet JS,Darbar UR,Griffiths GS,Bulman JS,Brägger U,Bürgin W,Newman HN

    更新日期:1997-06-01 00:00:00

  • Inhibitory effect of Weissella cibaria isolates on the production of volatile sulphur compounds.

    abstract:AIMS:The objective of this study was to characterize the inhibitory effects of Weissella cibaria isolates on volatile sulphur compounds (VSC) production both in vitro and in vivo. MATERIAL AND METHODS:We isolated and identified three hydrogen peroxide-generating lactobacilli from children's saliva, and assessed their ...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章

    doi:10.1111/j.1600-051X.2006.00893.x

    authors: Kang MS,Kim BG,Chung J,Lee HC,Oh JS

    更新日期:2006-03-01 00:00:00

  • Mechanical and chemical implant decontamination in surgical peri-implantitis treatment: preclinical "in vivo" study.

    abstract:OBJECTIVE:The aim of the present study was to evaluate the effect of a titanium brush and chemical agents following surgical treatment of experimental peri-implantitis. MATERIAL AND METHODS:Six implants were installed in the mandible of eight beagle dogs (unit of analysis) 3 months after tooth extraction. Experimental...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章

    doi:10.1111/jcpe.12566

    authors: Carral C,Muñoz F,Permuy M,Liñares A,Dard M,Blanco J

    更新日期:2016-08-01 00:00:00

  • Diode laser for harvesting de-epithelialized palatal graft in the treatment of gingival recession defects: a randomized clinical trial.

    abstract:AIMS:The aim of present randomized controlled clinical study was to evaluate the effects of the use of diode laser for graft harvesting and palatal wound irradiation on post-operative morbidity and root coverage outcomes after a coronally advanced flap (CAF) with de-epithelialized gingival grafts (DGG). METHODS:Fifty-...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/jcpe.12487

    authors: Ozcelik O,Seydaoglu G,Haytac CM

    更新日期:2016-01-01 00:00:00

  • Clinical course of chronic periodontitis. II. Incidence, characteristics and time of occurrence of the initial periodontal lesion.

    abstract:AIM:The purpose of this study was to assess the initiation and progression of periodontal disease during adult life. MATERIALS AND METHODS:In a 26-year longitudinal investigation of the initiation and progression of chronic periodontitis that started in 1969 and included 565 men of Norwegian middle class, 223 who had ...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章

    doi:10.1034/j.1600-051x.2003.00399.x

    authors: Heitz-Mayfield LJ,Schätzle M,Löe H,Bürgin W,Anerud A,Boysen H,Lang NP

    更新日期:2003-10-01 00:00:00

  • Personal risk factors for generalized periodontitis.

    abstract::Periodontitis is generally considered to be a consequence of an unfavourable host-parasite interaction in which bacteria are the determinants of disease. An intense search continues for the bacteria, specific or non-specific, that are responsible for periodontitis and various forms of the periodontal diseases have bee...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1600-051x.1995.tb00125.x

    authors: Clarke NG,Hirsch RS

    更新日期:1995-02-01 00:00:00

  • Lactate dehydrogenase activity in gingival crevicular fluid collected with filter paper strips: analysis in subjects with non-inflamed and mildly inflamed gingiva.

    abstract::A previous study of lactate dehydrogenase (LDH) in gingival crevicular fluid (GCF) suggested that the concentration is 10 to 25 times that of serum (means = 2300 international units/1 versus 100 IU/1 for serum). That study used capillary tubes to collect microliter amounts of GCF. Since invasive collection techniques ...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章

    doi:10.1111/j.1600-051x.1985.tb01374.x

    authors: Lamster IB,Mandella RD,Gordon JM

    更新日期:1985-02-01 00:00:00

  • Relationship of ascorbic acid levels of blood and gingival tissue with response to periodontal therapy.

    abstract::The effect of ascorbic acid megadoses on gingival clinical parameters and vitamin content of blood and gingival tissue was studied. 10 nondeficient individuals, carefully matched according to age, periodontal status, and oral hygiene level, were divided into 2 groups: one received 250 mg q.i.d. of ascorbic acid and th...

    journal_title:Journal of clinical periodontology

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1600-051x.1984.tb01319.x

    authors: Woolfe SN,Kenney EB,Hume WR,Carranza FA Jr

    更新日期:1984-03-01 00:00:00