Dose response of chlorhexidine against plaque and comparison with triclosan.

Abstract:

:The optimum dose of chlorhexidine delivered by mouthrinse, which balances efficacy against local side-effects, is generally considered to be in the region of 20 mg 2 x daily. Unfortunately, there have been few dose-response studies for chlorhexidine mouthrinses and for these, only limited details are published. The aims of this study were to determine the dose response of chlorhexidine to plaque inhibition and position a 0.1% triclosan rinse within this model. 28 subjects took part in this 7-treatment, double-blind, randomised cross-over 4-day plaque regrowth study. The rinses were 0.01%, 0.05%, 0.1% and 0.2% chlorhexidine, 0.1% triclosan and minus active controls for chlorhexidine and triclosan. On day 1 from a zero plaque baseline, volunteers suspended tooth-cleaning and commenced supervised 2 x daily rinsing with 10 ml volumes of the allocated rinses. On Day 5, plaque was scored by index and area. Treatment differences between the 7 rinses were highly significant. A clear dose-response pattern was seen for chlorhexidine with mean plaque scores decreasing with increasing dose. Even at 0.01%, chlorhexidine showed considerable and significant plaque inhibition compared to control. Triclosan at 0.1% showed limited plaque inhibition and less than 0.01% chlorhexidine. The findings of this study suggest that consideration could be given to low concentration chlorhexidine rinses as adjuncts to oral hygiene.

journal_name

J Clin Periodontol

authors

Jenkins S,Addy M,Newcombe RG

doi

10.1111/j.1600-051x.1994.tb00313.x

subject

Has Abstract

pub_date

1994-04-01 00:00:00

pages

250-5

issue

4

eissn

0303-6979

issn

1600-051X

journal_volume

21

pub_type

临床试验,杂志文章,随机对照试验
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    abstract:BACKGROUND:Diabetes mellitus (DM) is undiagnosed in approximately 1/2 of the patients actually suffering from the disease. In addition, the prevalence of DM is more than 2x as high in patients with periodontitis when compared to periodontally healthy subjects. Thus, a high number of patients with periodontitis may have...

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    doi:10.1034/j.1600-051x.2002.290306.x

    authors: Beikler T,Kuczek A,Petersilka G,Flemmig TF

    更新日期:2002-03-01 00:00:00

  • Exercise attenuates alveolar bone loss and anxiety-like behaviour in rats with periodontitis.

    abstract:AIM:To evaluate the effects of physical training on inflammatory and behavioural parameters of Wistar rats with periodontal disease (PD). MATERIALS AND METHODS:Twenty four animals were distributed in a 2 × 2 factorial design (with and without exercise, with and without PD). Trained animals swimmed one hour daily durin...

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    doi:10.1111/jcpe.12794

    authors: Andrade EF,Orlando DR,Gomes JAS,Foureaux RC,Costa RC,Varaschin MS,Rogatto GP,de Moura RF,Pereira LJ

    更新日期:2017-11-01 00:00:00

  • Cost effectiveness of periodontal services.

    abstract::This paper presents the combined use of decision trees and cost-effectiveness analysis to determine on which patients new diagnostic tests can be useful, and whether they can change the dentist's decision to provide different services and thus improve patient outcomes in 5 different categories of patients. A decision ...

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    doi:10.1111/j.1600-051x.1996.tb02089.x

    authors: Douglass CW,Fox CH

    更新日期:1996-03-01 00:00:00

  • Comparison of body composition and periodontal disease using nutritional assessment techniques: Third National Health and Nutrition Examination Survey (NHANES III).

    abstract:OBJECTIVES:The objective of this study was to investigate the association of body composition (obesity) and periodontal disease using simple, inexpensive nutritional assessment techniques available in the Third National Health and Nutrition Examination Survey (NHANES III). MATERIAL AND METHODS:Caucasian subjects, aged...

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    doi:10.1034/j.1600-051x.2003.00353.x

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  • Mouse model of experimental periodontitis induced by Porphyromonas gingivalis/Fusobacterium nucleatum infection: bone loss and host response.

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    pub_type: 杂志文章

    doi:10.1111/j.1600-051X.2009.01393.x

    authors: Polak D,Wilensky A,Shapira L,Halabi A,Goldstein D,Weiss EI,Houri-Haddad Y

    更新日期:2009-05-01 00:00:00

  • Evidence grade associating periodontitis with preterm birth and/or low birth weight: II: a systematic review of randomized trials evaluating the effects of periodontal treatment.

    abstract:AIM:The aim of this systematic review was to evaluate whether maternal periodontal disease treatment (MPDT) can reduce the incidence of preterm birth (PB) and/or low birth weight (LBW). METHODS:The Cochrane Central Register of Controlled Trials, MEDLINE and EMBASE were searched for entries up to October 2010 without r...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1111/j.1600-051X.2011.01761.x

    authors: Chambrone L,Pannuti CM,Guglielmetti MR,Chambrone LA

    更新日期:2011-10-01 00:00:00

  • Sinus augmentation using rhBMP-2/ACS in a mini-pig model: Influence of an adjunctive ceramic bone biomaterial.

    abstract:BACKGROUND:Recombinant human bone morphogenetic protein-2 in an absorbable collagen sponge carrier (rhBMP-2/ACS) has been shown to support significant bone formation when used to augment the maxillary sinus for implant dentistry. Nevertheless, bone biomaterials have been suggested to extend rhBMP-2/ACS with limited sup...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章

    doi:10.1111/jcpe.12921

    authors: Susin C,Lee J,Fiorini T,de Freitas RM,Chiu HC,Prasad HS,Buxton AN,Wikesjö UM

    更新日期:2018-08-01 00:00:00

  • Effect of folate on phenytoin hyperplasia.

    abstract::There have been some reports that folic acid inhibits phenytoin-induced gingival hyperplasia. The purpose of this double-blind study was to quantify clinically the effects of both systemic and topical administration of folic acid on phenytoin-induced gingival overgrowth in man. For a period of 6 months, one group of p...

    journal_title:Journal of clinical periodontology

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1600-051x.1987.tb00983.x

    authors: Drew HJ,Vogel RI,Molofsky W,Baker H,Frank O

    更新日期:1987-07-01 00:00:00

  • Keratinized tissue gain after free gingival graft augmentation procedures around teeth and dental implants: A prospective observational study.

    abstract:AIM:The primary goal was to compare the amount of keratinized tissue width (KTW) gain after free gingival graft (FGG) procedures around implants and teeth after 6 and 12 months of healing. MATERIALS AND METHODS:Patients with mucogingival defects (<2 mm of KT) around teeth and implants underwent a gingival augmentation...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章

    doi:10.1111/jcpe.13394

    authors: Golmayo P,Barallat L,Losada M,Valles C,Nart J,Pascual-La Rocca A

    更新日期:2021-02-01 00:00:00

  • Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.

    abstract::A new periodontitis classification scheme has been adopted, in which forms of the disease previously recognized as "chronic" or "aggressive" are now grouped under a single category ("periodontitis") and are further characterized based on a multi-dimensional staging and grading system. Staging is largely dependent upon...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章

    doi:10.1111/jcpe.12946

    authors: Papapanou PN,Sanz M,Buduneli N,Dietrich T,Feres M,Fine DH,Flemmig TF,Garcia R,Giannobile WV,Graziani F,Greenwell H,Herrera D,Kao RT,Kebschull M,Kinane DF,Kirkwood KL,Kocher T,Kornman KS,Kumar PS,Loos BG,Machtei E

    更新日期:2018-06-01 00:00:00

  • Effect of non-erupted 3rd molars on distal roots and supporting structures of approximal teeth. A radiographic survey of 202 cases.

    abstract::Root resorption of 2nd molars in proximity to non-erupted 3rd molars has been widely reported. The purpose of this study was to determine the prevalence of root resorption in second molars adjacent to non-erupted third molars. Its association to age and gender of the patient, location and inclination of the non-erupte...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章

    doi:10.1111/j.1600-051x.1996.tb00616.x

    authors: Nemcovsky CE,Libfeld H,Zubery Y

    更新日期:1996-09-01 00:00:00

  • Microbiology in the management of destructive periodontal disease.

    abstract::This paper summarizes the rationale for the application of microbiology in the management of destructive periodontal diseases. The subgingival microbiota in patients with severe periodontitis is complex and contains high numbers of obligate anaerobic bacteria as well as facultative micro-organisms. It has become clear...

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    pub_type: 杂志文章,评审

    doi:10.1111/j.1600-051x.1991.tb02308.x

    authors: van Winkelhoff AJ,de Graaff J

    更新日期:1991-07-01 00:00:00

  • Radiographic study of the prevalence of periodontal bone loss in Australian school-aged children attending the Royal Dental Hospital of Melbourne.

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    pub_type: 杂志文章

    doi:10.1111/j.1600-051X.2005.00767.x

    authors: Darby IB,Lu J,Calache H

    更新日期:2005-09-01 00:00:00

  • Increased release of elastase from in vitro activated peripheral neutrophils in patients with adult periodontitis.

    abstract::The main object of this study was to determine if there was a difference between patients with adult periodontitis and healthy controls in the release of elastase. We also wanted to test the release of alpha-1-antitrypsin and lactoferrin from in vitro-activated peripheral neutrophils. A leukocyte-rich preparation from...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章

    doi:10.1034/j.1600-051x.1999.260402.x

    authors: Figueredo CM,Gustafsson A,Asman B,Bergström K

    更新日期:1999-04-01 00:00:00

  • A controlled 6-month clinical trial to study the effects of a stannous fluoride dentifrice on gingivitis.

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    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1600-051X.2007.01109.x

    authors: Mallatt M,Mankodi S,Bauroth K,Bsoul SA,Bartizek RD,He T

    更新日期:2007-09-01 00:00:00

  • Periodontal repair in dogs: effect of rhBMP-2 concentration on regeneration of alveolar bone and periodontal attachment.

    abstract::The objective of this study was to evaluate the effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) concentration on regeneration of alveolar bone and cementum, and on associated root resorption and ankylosis. Contralateral, critical size, supra-alveolar, periodontal defects were surgically produced and...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章

    doi:10.1034/j.1600-051x.1999.260610.x

    authors: Wikesjö UM,Guglielmoni P,Promsudthi A,Cho KS,Trombelli L,Selvig KA,Jin L,Wozney JM

    更新日期:1999-06-01 00:00:00

  • Periodontal status of Finnish adolescents with insulin-dependent diabetes mellitus.

    abstract::The periodontal status of 85 12-18 year-old Finnish adolescents with insulin-dependent diabetes mellitus (IDDM) and their paired, age- and sex-matched healthy controls was assessed clinically and radiographically. The clinical examination consisted of plaque index, gingival index (GI), retentive calculus index, WHO co...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章

    doi:10.1111/j.1600-051x.1989.tb01028.x

    authors: Sandholm L,Swanljung O,Rytömaa I,Kaprio EA,Mäenpää J

    更新日期:1989-11-01 00:00:00

  • How do visual-spatial and psychomotor abilities influence clinical performance in periodontal plastic surgery?

    abstract:AIM:We want to evaluate the relationship of self-assessed experience and proficiency, manual dexterity and visual-spatial ability with surgical performance. MATERIAL AND METHODS:A total of 26 professionals were included in the study which consisted of four parts: (a) self-assessment by a questionnaire regarding profic...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章

    doi:10.1111/jcpe.13028

    authors: Burkhardt R,Hämmerle CHF,Lang NP,Research Group on Oral Soft Tissue Biology & Wound Healing.

    更新日期:2019-01-01 00:00:00

  • Implants and infections with special reference to oral bacteria.

    abstract::Osseointegration or bony anchorage of oral implants was first described by Brånemark and coworkers. This type of connection between the titanium oxide layer and the bone gives stable long-term results for the implants in function. Fibrous tissue interphase between implant and bone will allow mobility which will gradua...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2710.1992.tb01226.x

    authors: Haanaes HR

    更新日期:1990-08-01 00:00:00

  • Analysis of the TGF-beta1 promoter polymorphism (C-509T) in patients with chronic periodontitis.

    abstract:BACKGROUND:A polymorphism in the promoter region of the transforming growth factor beta-1 (TGF-beta1) gene was described at position -509. This polymorphism represents a C-to-T base exchange, which creates a YY1 consensus sequence in an area involved with down transcription regulation. This polymorphism has been associ...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章

    doi:10.1034/j.1600-051x.2003.00323.x

    authors: de Souza AP,Trevilatto PC,Scarel-Caminaga RM,de Brito RB,Line SR

    更新日期:2003-06-01 00:00:00

  • The relationship of the periodontal status to fluoride levels of alveolar bone and tooth roots.

    abstract::The periodontal status and fluoride levels of alveolar bone and tooth roots were compared for subjects from a high (2.5 ppm F) and a low (less than 0.05 ppm F) fluoride area. The plaque index, gingival index, probing depth and loss of attachment were measured to determine the periodontal status. The fluoride levels we...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章

    doi:10.1111/j.1600-051x.1988.tb01573.x

    authors: Reddy J,Grobler SR

    更新日期:1988-04-01 00:00:00

  • Clinical, microbiological and host defense parameters associated with a case of localized prepubertal periodontitis.

    abstract::A 4-year-old Japanese boy was referred to Osaka University Dental Hospital because of severe mobility and pain of the right lower primary canine. The canine had severe bone loss and a pocket depth exceeding 5-6 mm. The left lower canine showed slight mobility and moderate alveolar bone loss. The other primary teeth sh...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章

    doi:10.1111/j.1600-051x.1995.tb01771.x

    authors: Yoshida-Minami I,Kishimoto K,Suzuki A,Fujiwara T,Shintani S,Morisaki I,Sobue S,Miyamoto M,Nagai A,Kurihara H

    更新日期:1995-01-01 00:00:00

  • Periodontal therapy by local delivery of tetracycline.

    abstract::The present investigation assessed the feasibility of treating periodontal disease by controlled delivery of antibacterial agents from within periodontal pockets. Tetracycline-filled hollow fibers placed in the gingival sulcus were shown to have a dramatic effect both on the periodontal microflora and clinical manifes...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章

    doi:10.1111/j.1600-051x.1979.tb02186.x

    authors: Goodson JM,Haffajee A,Socransky SS

    更新日期:1979-04-01 00:00:00

  • A longitudinal study on insulin-dependent diabetes mellitus and periodontal disease.

    abstract::In the present two-year longitudinal investigation, the progression of periodontal disease was assessed after 1 year from the baseline examination in 38 dentate subjects and after 2 years in 22 dentate subjects with a mean duration of 18 years of insulin-dependent diabetes mellitus. The diabetics, aged 35 to 56 years ...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章

    doi:10.1111/j.1600-051x.1993.tb00338.x

    authors: Seppälä B,Seppälä M,Ainamo J

    更新日期:1993-03-01 00:00:00

  • Chronic lymphocytic leukaemia with gingival and palatal deposits.

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    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章

    doi:10.1111/j.1600-051x.1994.tb01173.x

    authors: Porter SR,Matthews RW,Scully C

    更新日期:1994-09-01 00:00:00

  • Prevalence of Actinobacillus actinomycetemcomitans and clinical conditions in children and adolescents from rural and urban areas of central Italy.

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    pub_type: 杂志文章

    doi:10.1034/j.1600-051x.2000.027008549.x

    authors: Paolantonio M,di Bonaventura G,di Placido G,Tumini V,Catamo G,di Donato A,Piccolomini R

    更新日期:2000-08-01 00:00:00

  • Bone modelling at fresh extraction sockets: immediate implant placement versus spontaneous healing: an experimental study in the beagle dog.

    abstract:OBJECTIVES:The purpose of this investigation is to describe histologically the undisturbed healing of fresh extraction sockets when compared to immediate implant placement. METHODS:In eight beagle dogs, after extraction of the 3P3 and 4P4, implants were inserted into the distal sockets of the premolars, while the mesi...

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    pub_type: 杂志文章

    doi:10.1111/j.1600-051X.2011.01803.x

    authors: Vignoletti F,Discepoli N,Müller A,de Sanctis M,Muñoz F,Sanz M

    更新日期:2012-01-01 00:00:00

  • Polymorphisms in genes coding for enzymes metabolizing smoking-derived substances and the risk of periodontitis.

    abstract:OBJECTIVES:Although the direct cause for periodontitis is oral bacterial infection, its progression depends upon genetic and environmental factors. Smoking, one of the environmental factors, is a risk factor for the development and severity of periodontitis. Therefore, individual susceptibility to periodontitis may be ...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章

    doi:10.1111/j.1600-051X.2004.00587.x

    authors: Kim JS,Park JY,Chung WY,Choi MA,Cho KS,Park KK

    更新日期:2004-11-01 00:00:00

  • The prevalence of BANA-hydrolyzing periodontopathic bacteria in smokers.

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    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章

    doi:10.1111/j.1600-051x.1999.tb02526.x

    authors: Kazor C,Taylor GW,Loesche WJ

    更新日期:1999-12-01 00:00:00

  • Multi-centre, randomized clinical trial on the efficacy and safety of recombinant human platelet-derived growth factor with β-tricalcium phosphate in human intra-osseous periodontal defects.

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    更新日期:2011-02-01 00:00:00