Abstract:
AIMS:To update the existing scientific evidence on the efficacy of local antimicrobials as adjuncts to subgingival debridement in the treatment of chronic periodontitis. MATERIAL AND METHODS:Fifty-six papers were selected, reporting data from 52 different investigations. All the studies reported changes in probing pocket depth (PPD) and clinical attachment level (CAL) and most in plaque index (PlI) and/or bleeding on probing (BOP). Meta-analyses were performed with the data retrieved from the studies fulfilling the inclusion criteria. RESULTS:The overall effect of the subgingival application of antimicrobials was statistically significant (p = 0.000) for both changes in PPD and CAL with a weighted mean difference (WMD) of -0.407 and -0.310 mm respectively. No significant differences occurred for changes in BOP and PlI. Subgingival application of tetracycline fibres, sustained released doxycycline and minocycline demonstrated a significant benefit in PPD reduction (WMD between 0.5 and 0.7 mm). The rest of the tested outcomes demonstrated a high heterogeneity. The local application of chlorhexidine and metronidazole showed a minimal effect when compared with placebo (WMD between 0.1 and 0.4 mm). CONCLUSIONS:The scientific evidence supports the adjunctive use of local antimicrobials to debridement in deep or recurrent periodontal sites, mostly when using vehicles with proven sustained release of the antimicrobial.
journal_name
J Clin Periodontoljournal_title
Journal of clinical periodontologyauthors
Matesanz-Pérez P,García-Gargallo M,Figuero E,Bascones-Martínez A,Sanz M,Herrera Ddoi
10.1111/jcpe.12026subject
Has Abstractpub_date
2013-03-01 00:00:00pages
227-41issue
3eissn
0303-6979issn
1600-051Xjournal_volume
40pub_type
杂志文章,meta分析,评审abstract::The oral features of a patient with notable maxillary and mandibular gingival enlargement secondary to leukaemic infiltration in chronic lymphocyte leukaemia are presented. ...
journal_title:Journal of clinical periodontology
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journal_title:Journal of clinical periodontology
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journal_title:Journal of clinical periodontology
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journal_title:Journal of clinical periodontology
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journal_title:Journal of clinical periodontology
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journal_title:Journal of clinical periodontology
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journal_title:Journal of clinical periodontology
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journal_title:Journal of clinical periodontology
pub_type: 杂志文章
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journal_title:Journal of clinical periodontology
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pub_type: 临床试验,杂志文章,随机对照试验
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