Increased bone loss and amount of osteoclasts in kinin B1 receptor knockout mice.


AIM:The pathophysiology of periodontal diseases involves aspects of immunity and bone remodelling. Considering the role of the kinin B1 receptor (Bdkrb1) in inflammation and healing, the purpose of this study was to evaluate the contribution of Bdkrb1 to the pathogenesis of periodontitis. MATERIAL AND METHODS:We used a model of ligature-induced experimental periodontitis (LIEP) in mice lacking Bdkrb1 (Bdkrb1(-/-) ) to test the role of this receptor in bone loss and cytokine secretion by lymph nodes cells. Angiotensin-converting enzyme inhibitor (ACEi) was used as a pharmacological strategy to support the genetic model. Also, autonomous effect of Bdkrb1 deletion was evaluated in osteoclasts precursors from bone marrow. RESULTS:Bdkrb1(-/-) mice exhibit increased bone loss and IL-17 secretion in response to LIEP when compared to wild type. LIEP does not modify TNF-α, IFN-γ and IL-10 levels in Bdkrb1(-/-) mice after 21 days. Bone marrow cells from Bdkrb1(-/-) displayed increased differentiation into functional osteoclasts with consistent artificial calcium phosphate degradation. Furthermore, treatment of mice with ACEi prevented bone destruction. CONCLUSION:Bdkrb1 participates in the pathogenesis of LIEP bone loss possibly through mechanisms that involve modulation of the TH 17 response, thereby demonstrating its role in the development of periodontitis.


J Clin Periodontol


Gonçalves-Zillo TO,Pugliese LS,Sales VM,Mori MA,Squaiella-Baptistão CC,Longo-Maugéri IM,Lopes JD,de Oliveira SM,Monteiro AC,Pesquero JB




Has Abstract


2013-07-01 00:00:00












  • Electron microscopic study of junctional and oral gingival epithelia in the juvenile and adult beagle dog.

    abstract::A previous study demonstrated structural differences in the junctional epithelium between juvenile and adult dogs. In juveniles the junctional epithelium showed some resemblances to the oral gingival epithelium, and a cuticular structure at the dento-gingival junction was of particular interest. The oral gingival epit...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: Matsson L,Theilade J,Attström R

    更新日期:1979-12-01 00:00:00

  • Gingivitis in the deciduous and permanent dentition. An experimental study in the dog.

    abstract::The present investigation was performed in order to study the reaction of the gingiva in the deciduous and permanent dentition of dogs to 3 weeks of plaque accumulation. The study was carried out in 10 beagles, divided into 2 groups of 5 dogs each; group I and group II. When the dogs of group I were 10 weeks old, a me...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: Berglundh T,Liljenberg B,Ericsson I,Lindhe J

    更新日期:1989-08-01 00:00:00

  • Chronic lymphocytic leukaemia with gingival and palatal deposits.

    abstract::The oral features of a patient with notable maxillary and mandibular gingival enlargement secondary to leukaemic infiltration in chronic lymphocyte leukaemia are presented. ...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: Porter SR,Matthews RW,Scully C

    更新日期:1994-09-01 00:00:00

  • Digital subtraction radiography in assessing bone changes in periodontal defects following guided tissue regeneration.

    abstract::19 patients with a total of 23 periodontal lesions were selected for the study. Following flap-elevation, an occlusive membrane (Gore Tex) adjusted to the size and shape of the lesion was applied. The membrane was removed 4-6 weeks later by a 2nd operation. Clinical attachment levels were measured and intraoral radiog...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: Wenzel A,Warrer K,Karring T

    更新日期:1992-03-01 00:00:00

  • Comparison of the plaque removal efficacy of a new flossing aid (Quik Floss) to finger flossing.

    abstract::The purpose of this clinical trial was to compare the effectiveness and safety of a new dental flossing device (Quik Floss) to finger flossing in plaque removal, reduction of gingival inflammation and patient preference. 30 healthy, non-flossing adults with 20 natural teeth, a plaque index (PI) of at least 1.8 and a g...

    journal_title:Journal of clinical periodontology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Carter-Hanson C,Gadbury-Amyot C,Killoy W

    更新日期:1996-09-01 00:00:00

  • Prognostic value of a simplified method for periodontal risk assessment during supportive periodontal therapy.

    abstract:AIM:To evaluate the association between risk scores generated with a simplified method for periodontal risk assessment (Perio Risk), and tooth loss as well as bone loss during supportive periodontal therapy (SPT). MATERIALS & METHODS:Data related to 109 patients (42 males; mean age: 42.2 ± 10.2 years, range 22-62) enr...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: Trombelli L,Minenna L,Toselli L,Zaetta A,Checchi L,Checchi V,Nieri M,Farina R

    更新日期:2017-01-01 00:00:00

  • Periodontal manifestations of systemic diseases and developmental and acquired conditions: Consensus report of workgroup 3 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.

    abstract:BACKGROUND:A variety of systemic diseases and conditions can affect the course of periodontitis or have a negative impact on the periodontal attachment apparatus. Gingival recessions are highly prevalent and often associated with hypersensitivity, the development of caries and non-carious cervical lesions on the expose...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章,实务指引


    authors: Jepsen S,Caton JG,Albandar JM,Bissada NF,Bouchard P,Cortellini P,Demirel K,de Sanctis M,Ercoli C,Fan J,Geurs NC,Hughes FJ,Jin L,Kantarci A,Lalla E,Madianos PN,Matthews D,McGuire MK,Mills MP,Preshaw PM,Reynolds MA

    更新日期:2018-06-01 00:00:00

  • Comparison of periodontitis patients' classification in the 2018 versus 1999 classification.

    abstract:OBJECTIVES:We aimed to assess how the 2018 and 1999 classifications of periodontal diseases reflect (a) patients' characteristics, (b) disease severity/extent/progression and (c) tooth loss (TL) during observation period. METHODS:A total of 251 patients were followed over 21.8 ± 6.2 years. For the 1999 classification,...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: Graetz C,Mann L,Krois J,Sälzer S,Kahl M,Springer C,Schwendicke F

    更新日期:2019-09-01 00:00:00

  • Dose response of chlorhexidine against plaque and comparison with triclosan.

    abstract::The optimum dose of chlorhexidine delivered by mouthrinse, which balances efficacy against local side-effects, is generally considered to be in the region of 20 mg 2 x daily. Unfortunately, there have been few dose-response studies for chlorhexidine mouthrinses and for these, only limited details are published. The ai...

    journal_title:Journal of clinical periodontology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Jenkins S,Addy M,Newcombe RG

    更新日期:1994-04-01 00:00:00

  • Root coverage procedures improve patient aesthetics. A systematic review and Bayesian network meta-analysis.

    abstract:BACKGROUND:The aim of this study was to perform a systematic review (SR) of randomized controlled trials (RCTs) to explore if periodontal plastic surgery procedures for the treatment of single and multiple gingival recessions (Rec) may improve aesthetics at patient and professional levels. MATERIAL AND METHODS:In orde...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章,meta分析


    authors: Cairo F,Pagliaro U,Buti J,Baccini M,Graziani F,Tonelli P,Pagavino G,Tonetti MS

    更新日期:2016-11-01 00:00:00

  • Analysis of changes in gingival contour from three-dimensional co-ordinate data in subjects with drug-induced gingival overgrowth.

    abstract:OBJECTIVES:This aim of this study was to develop and assess a technique that could be used to assess accurately the gingival volume changes seen in drug-induced gingival overgrowth by the analysis of data obtained from an entire gingival surface by means of three-dimensional imaging. MATERIAL AND METHODS:Stone dental ...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: Thomason JM,Ellis JS,Jovanovski V,Corson M,Lynch E,Seymour RA

    更新日期:2005-10-01 00:00:00

  • Formation and regeneration of a Wnt-responsive junctional epithelium.

    abstract:AIM:To identify the molecular mechanisms mediating the persistent defensive functions of the self-renewing junctional epithelium (JE). MATERIALS AND METHODS:Two strains of Wnt reporter mice, Axin2CreErt2/+ ;R26RmTmG/+ and Axin2LacZ/+ , were employed, along with three clinically relevant experimental scenarios where th...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: Yuan X,Chen J,Van Brunt LA,Grauer J,Xu Q,Pei X,Wang L,Zhao Y,Helms JA

    更新日期:2020-12-01 00:00:00

  • Local delivery of chemotherapeutic agents in periodontal therapy: has its time arrived?

    abstract::The concept of locally delivering chemotherapeutic agents to the periodontal pocket as a method to treat periodontal disease has been studied for over 20 years. A number of locally delivered chemotherapeutic agents in periodontal therapy are either currently available or under investigation. Clinical efficacy derives ...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: Finkelman RD,Williams RC

    更新日期:1998-11-01 00:00:00

  • Fluctuations in crevicular and salivary anti-A. viscosus antibody levels in response to treatment of gingivitis.

    abstract::Experimental gingivitis studies support a pathogenic rôle for Actinomyces viscosus because of its numerical predominance in disease-associated plaques. The aims of the present investigation were to quantify specific crevicular IgG against A. viscosus before and after conventional gingivitis treatment and to determine ...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: Tynelius-Bratthall G,Ellen RP

    更新日期:1985-10-01 00:00:00

  • Clinical research activity in periodontal medicine: a systematic mapping of trial registers.

    abstract:AIM:The primary aim of the study was to systematically map registration records on periodontal medicine in clinical trial registers. The secondary aim was to assess the evolution of periodontal medicine in clinical periodontal research as a whole. MATERIAL AND METHODS:We searched all registration records related to pe...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章,评审


    authors: Monsarrat P,Blaizot A,Kémoun P,Ravaud P,Nabet C,Sixou M,Vergnes JN

    更新日期:2016-05-01 00:00:00

  • Width/length ratios of normal clinical crowns of the maxillary anterior dentition in man.

    abstract::The purpose of this investigation was to analyze the clinical crown of the 3 tooth groups of the maxillary anterior sextant of the permanent dentition of normal subjects with respect to (i) width, length and the width/length ratios and (ii) determine if there is a correlation between tooth dimensions or tooth group ra...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: Sterrett JD,Oliver T,Robinson F,Fortson W,Knaak B,Russell CM

    更新日期:1999-03-01 00:00:00

  • The efficacy of 0.12% chlorhexidine mouthrinse compared with 0.2% on plaque accumulation and periodontal parameters: a systematic review.

    abstract:OBJECTIVES:The aim of this systematic review was to evaluate the effects of 0.12% chlorhexidine (CHX) mouthrinse compared with 0.2% on plaque and periodontal parameters. MATERIALS AND METHODS:MEDLINE-PubMed and the Cochrane Central Register of Controlled Trials were searched for (randomized) clinical trials and cohort...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章,评审


    authors: Berchier CE,Slot DE,Van der Weijden GA

    更新日期:2010-09-01 00:00:00

  • Polymorphisms in genes coding for enzymes metabolizing smoking-derived substances and the risk of periodontitis.

    abstract:OBJECTIVES:Although the direct cause for periodontitis is oral bacterial infection, its progression depends upon genetic and environmental factors. Smoking, one of the environmental factors, is a risk factor for the development and severity of periodontitis. Therefore, individual susceptibility to periodontitis may be ...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: Kim JS,Park JY,Chung WY,Choi MA,Cho KS,Park KK

    更新日期:2004-11-01 00:00:00

  • Toothbrushing promotes gingival fibroblast proliferation more effectively than removal of dental plaque.

    abstract:OBJECTIVES:Removal of dental plaque is an essential element of periodontal treatment. However, there have also been studies of the effects of the mechanical stimulation provided by toothbrushing on gingival host-defense mechanisms. The aim of the study was to evaluate the effects of toothbrushing on gingival fibroblast...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: Horiuchi M,Yamamoto T,Tomofuji T,Ishikawa A,Morita M,Watanabe T

    更新日期:2002-09-01 00:00:00

  • Oral hygiene phase revisited: How different study designs have affected results in intervention studies.

    abstract::Every periodontal researcher have been taught, and every textbook in periodontics have advocated, that a phase in which the patient is meticulously motivated and instructed in proper oral hygiene-the oral hygiene phase-must be included in any periodontal intervention. However, how is this oral hygiene phase actually p...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章,评审


    authors: Preus HR,Maharajasingam N,Rosic J,Baelum V

    更新日期:2019-05-01 00:00:00

  • Microscopic spirochete counts in untreated subjects with and without periodontal tissue destruction.

    abstract::The purpose of the study was to determine microscopically the %s of spirochetes at sites without periodontal destruction in subjects with destructive periodontal diseases (cases) and in subjects free of it (controls), who had not received professional prophylaxis. From a sample of 164 individuals aged between 30-44 ye...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: Lembariti BS,Mikx FH,van Palenstein Helderman WH

    更新日期:1995-03-01 00:00:00

  • Antagonists of Wnt/β-catenin signalling in the periodontitis associated with type 2 diabetes and smoking.

    abstract:AIM:This study evaluated the levels of sclerostin (SOST) and Dickkopf (DKK)-1 in the chronic periodontitis (CP) associated with type 2 diabetes (DM) and/or smoking. Relationships between SOST, DDK1, RANKL, OPG, IL-1ß, IL-6 and TNF-α, and pathogens were assessed. MATERIAL AND METHODS:The study population included non-d...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: Miranda TS,Napimoga MH,Feres M,Marins LM,da Cruz DF,da Silva HDP,Duarte PM

    更新日期:2018-03-01 00:00:00

  • Predictive power of various models for longitudinal attachment level change.

    abstract::Several statistical models that have been suggested in the periodontal literature for describing longitudinal attachment level changes, such as the gradual loss, single-burst, multiple-burst, and random walk models as well as other models introduced in this paper are compared by their power to predict future attachmen...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: Yang MC,Marks RG,Clark WB,Magnusson I

    更新日期:1992-02-01 00:00:00

  • Chemotherapeutic agents for controlling plaque and gingivitis.

    abstract::There has been a vigorous search for many years for chemical agents that could supplement or even supplant patient-dependent mechanical plaque control and thus reduce or prevent oral disease. 5 categories of agents or approaches have been considered: (1) broad spectrum antiseptics, (2) antibiotics aimed at specific ba...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章,评审


    authors: Mandel ID

    更新日期:1988-09-01 00:00:00

  • Quality of reporting of descriptive studies in implant dentistry. Critical aspects in design, outcome assessment and clinical relevance.

    abstract:OBJECTIVES:The aim of this study was to conduct a review on quality of reporting on descriptive studies in implant dentistry using the STROBE Statement and to analyse possible changes in quality of reporting on descriptive studies in implant dentistry over time. MATERIAL AND METHODS:A hand search to select descriptive...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章,评审


    authors: Meijer HJ,Raghoebar GM

    更新日期:2012-02-01 00:00:00

  • Antimicrobial peptides and periodontal disease.

    abstract:AIMS:The goal of this review is to identify the antimicrobial proteins in the oral fluids, saliva and gingival crevicular fluid and identify functional families and candidates for antibacterial treatment. RESULTS:Periodontal biofilms initiate a cascade of inflammatory and immune processes that lead to the destruction ...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章,评审


    authors: Gorr SU,Abdolhosseini M

    更新日期:2011-03-01 00:00:00

  • The gingival biotype: measurement of soft and hard tissue dimensions - a radiographic morphometric study.

    abstract:BACKGROUND:Gingival biotypes have been reported to influence the outcome of restorative therapies. The aim of this study was to evaluate the correlation of different morphometric parameters with the thickness of the buccal gingiva and alveolar bone at different apico-coronal levels. METHODS:In 60 periodontally healthy...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: Stein JM,Lintel-Höping N,Hammächer C,Kasaj A,Tamm M,Hanisch O

    更新日期:2013-12-01 00:00:00

  • Prevalence of periodontitis in an adult population from an urban area in North Italy: findings from a cross-sectional population-based epidemiological survey.

    abstract:AIM:There is a paucity of up-to-date data regarding prevalence and risk indicators of periodontitis in Italy. Therefore, the aim of this study was to evaluate the prevalence of periodontitis and its risk indicators among adults from an urban area in North Italy. MATERIAL AND METHODS:This cross-sectional survey used a ...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: Aimetti M,Perotto S,Castiglione A,Mariani GM,Ferrarotti F,Romano F

    更新日期:2015-07-01 00:00:00

  • Dental biofilms at healthy and inflamed gingival margins.

    abstract:OBJECTIVES:The increased plaque formation observed in gingival inflammation is not fully understood. Receptor proteins in the dental pellicle might influence bacterial adhesion and subsequent plaque formation. The purpose of the present study was to examine proteins and microorganisms in dental biofilms, at healthy and...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: Rüdiger SG,Carlén A,Meurman JH,Kari K,Olsson J

    更新日期:2002-06-01 00:00:00

  • Periodontal reasons for tooth loss in an Asian population.

    abstract::This study analysed data on periodontal reasons for tooth extractions, obtained from 52 dentists practising general dentistry in Singapore. The results revealed that, out of 2172 teeth extracted from 1276 patients, 35.8% were lost due to periodontal disease and 35.4% due to caries. Extraction due to periodontal proble...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: Ong G

    更新日期:1996-04-01 00:00:00