Abstract：
AIM:The pathophysiology of periodontal diseases involves aspects of immunity and bone remodelling. Considering the role of the kinin B1 receptor (Bdkrb1) in inflammation and healing, the purpose of this study was to evaluate the contribution of Bdkrb1 to the pathogenesis of periodontitis. MATERIAL AND METHODS:We used a model of ligature-induced experimental periodontitis (LIEP) in mice lacking Bdkrb1 (Bdkrb1(-/-) ) to test the role of this receptor in bone loss and cytokine secretion by lymph nodes cells. Angiotensin-converting enzyme inhibitor (ACEi) was used as a pharmacological strategy to support the genetic model. Also, autonomous effect of Bdkrb1 deletion was evaluated in osteoclasts precursors from bone marrow. RESULTS:Bdkrb1(-/-) mice exhibit increased bone loss and IL-17 secretion in response to LIEP when compared to wild type. LIEP does not modify TNF-α, IFN-γ and IL-10 levels in Bdkrb1(-/-) mice after 21 days. Bone marrow cells from Bdkrb1(-/-) displayed increased differentiation into functional osteoclasts with consistent artificial calcium phosphate degradation. Furthermore, treatment of mice with ACEi prevented bone destruction. CONCLUSION:Bdkrb1 participates in the pathogenesis of LIEP bone loss possibly through mechanisms that involve modulation of the TH 17 response, thereby demonstrating its role in the development of periodontitis.
journal_name
J Clin Periodontoljournal_title
Journal of clinical periodontologyauthors
Gonçalves-Zillo TO,Pugliese LS,Sales VM,Mori MA,Squaiella-Baptistão CC,Longo-Maugéri IM,Lopes JD,de Oliveira SM,Monteiro AC,Pesquero JBdoi
10.1111/jcpe.12097subject
Has Abstractpub_date
2013-07-01 00:00:00pages
653-60issue
7eissn
0303-6979issn
1600-051Xjournal_volume
40pub_type
杂志文章abstract：OBJECTIVE:To determine the concentration of cathepsin K secreted into the crevicular fluid around dental implants and its correlation with clinical parameters of healthy implants and implants showing clinical signs of peri-implantitis. MATERIAL AND METHODS:Nineteen patients with 40 implants with and without peri-impla...
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journal_title：Journal of clinical periodontology
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journal_title：Journal of clinical periodontology
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pub_type： 临床试验,杂志文章,随机对照试验
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pub_type： 杂志文章,多中心研究,随机对照试验
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journal_title：Journal of clinical periodontology
pub_type： 杂志文章,评审
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journal_title：Journal of clinical periodontology
pub_type： 杂志文章,随机对照试验
doi：10.1111/j.1600-051X.2006.00962.x
更新日期：2006-09-01 00:00:00
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journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051X.2004.00617.x
更新日期：2004-11-01 00:00:00
abstract：AIMS:To systematically review the literature addressing the following focused questions: "What is the efficacy of either (#1) alternative or (#2) additional methods to professional mechanical plaque removal (PMPR) on progression of attachment loss during supportive periodontal therapy (SPT) in periodontitis patients?"....
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/jcpe.13269
更新日期：2020-07-01 00:00:00
