Increased bone loss and amount of osteoclasts in kinin B1 receptor knockout mice.

Abstract:

AIM:The pathophysiology of periodontal diseases involves aspects of immunity and bone remodelling. Considering the role of the kinin B1 receptor (Bdkrb1) in inflammation and healing, the purpose of this study was to evaluate the contribution of Bdkrb1 to the pathogenesis of periodontitis. MATERIAL AND METHODS:We used a model of ligature-induced experimental periodontitis (LIEP) in mice lacking Bdkrb1 (Bdkrb1(-/-) ) to test the role of this receptor in bone loss and cytokine secretion by lymph nodes cells. Angiotensin-converting enzyme inhibitor (ACEi) was used as a pharmacological strategy to support the genetic model. Also, autonomous effect of Bdkrb1 deletion was evaluated in osteoclasts precursors from bone marrow. RESULTS:Bdkrb1(-/-) mice exhibit increased bone loss and IL-17 secretion in response to LIEP when compared to wild type. LIEP does not modify TNF-α, IFN-γ and IL-10 levels in Bdkrb1(-/-) mice after 21 days. Bone marrow cells from Bdkrb1(-/-) displayed increased differentiation into functional osteoclasts with consistent artificial calcium phosphate degradation. Furthermore, treatment of mice with ACEi prevented bone destruction. CONCLUSION:Bdkrb1 participates in the pathogenesis of LIEP bone loss possibly through mechanisms that involve modulation of the TH 17 response, thereby demonstrating its role in the development of periodontitis.

journal_name

J Clin Periodontol

authors

Gonçalves-Zillo TO,Pugliese LS,Sales VM,Mori MA,Squaiella-Baptistão CC,Longo-Maugéri IM,Lopes JD,de Oliveira SM,Monteiro AC,Pesquero JB

doi

10.1111/jcpe.12097

subject

Has Abstract

pub_date

2013-07-01 00:00:00

pages

653-60

issue

7

eissn

0303-6979

issn

1600-051X

journal_volume

40

pub_type

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