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Substance P and neurokinin A in gingival crevicular fluid in periodontal health and disease.

Abstract：

:The aims of the present study were to investigate whether the tachykinins substance P and neurokinin A were present in gingival crevicular fluid in both periodontal health and disease and to study the relationship with periodontal inflammation. Gingival crevicular fluid (GCF) was collected from a healthy, a gingivitis and a periodontitis site in 20 subjects with periodontitis and from a healthy site in 20 subjects without periodontitis. The volume of GCF was measured and each sample subsequently analysed for substance P and neurokinin A by radioimmunoassay. There were significantly increased levels of substance P-like immunoreactivity (SP-LI) and neurokinin A-like immunoreactivity (NKA-LI) in gingivitis and periodontitis sites compared with healthy sites. Both tachykinins were significantly elevated in periodontitis affected subjects, with significantly more tachykinin-like immunoreactivity at healthy sites in periodontitis affected compared with periodontally-healthy subjects. Despite the considerable individual variation in the levels of SP-LI and NKA-LI, both tachykinins were present at levels at which they could have biological activity. It is concluded that substance P and neurokinin A may have a rôle in the pathogenesis of periodontal disease and that further investigations could prove useful in clarifying the mechanisms through which neuropeptides could modulate periodontal health and disease.

journal_name

J Clin Periodontol

journal_title

Journal of clinical periodontology

authors

Linden GJ,McKinnell J,Shaw C,Lundy FT

doi

10.1111/j.1600-051x.1997.tb01192.x

subject

Has Abstract

pub_date

1997-11-01 00:00:00

pages

799-803

issue

11

eissn

0303-6979

issn

1600-051X

journal_volume

24

pub_type

杂志文章

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