Periodontitis and arterial stiffness: a systematic review and meta-analysis.

Abstract:

INTRODUCTION AND AIMS:Patients with periodontitis have a higher risk of cardiovascular diseases, although a causal relationship between these conditions remains unclear. Arterial stiffness is considered a marker of arteriosclerosis and a risk factor for cardiovascular diseases. A systematic review of the literature on clinical studies using pulse wave velocity (PWV) to assess arterial stiffness in patients with periodontitis was carried out to answer the following questions: (i) Do patients with periodontitis have impaired arterial stiffness compared to non-periodontal diseased subjects? (ii) Is periodontal treatment effective as a means to improve arterial stiffness in patients with periodontitis? LITERATURE REVIEW:Literature search was done on different databases up to September 2014. All clinical studies (excluding case reports) using PWV in patients with periodontitis were retrieved for a full-text evaluation. A total of 10 studies were included. Patients with periodontitis have increased arterial stiffness compared to controls (PWV mean difference 0.85 m/s; 95% confidence interval: 0.53-1.16; p<0.00001). The only two interventional studies showed contradictory results on the effects of periodontal treatment on PWV. CONCLUSION:Patients with periodontitis appear to have higher values of PWV compared to controls. The effect of periodontal treatment on arterial stiffness remains unclear.

journal_name

J Clin Periodontol

authors

Schmitt A,Carra MC,Boutouyrie P,Bouchard P

doi

10.1111/jcpe.12467

subject

Has Abstract

pub_date

2015-11-01 00:00:00

pages

977-87

issue

11

eissn

0303-6979

issn

1600-051X

journal_volume

42

pub_type

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