Abstract：
OBJECTIVES:This study examined differences in the efficacy of antibiotics against a single strain of three periodontal pathogens grown in an artificial biofilm. METHODS:Single species biofilms were established with artificial saliva and one of the following bacterial strains: Actinobacillus actinomycetemcomitans Y4, Streptococcus constellatus 384b (a clinical isolate) and Porphyromonas gingivalis ATCC 33277. The efficacy of the antibiotics clindamycin, doxycycline, metronidazole, and moxifloxacin to these bacteria was determined using concentrations up to 100-fold minimal inhibitory concentration (MIC) to planctonic bacteria over 48 h. RESULTS:The ability of the bacteria to form a biofilm varied. The biofilms of S. constellatus 384b and A. actinomycetemcomitans Y4 contained more viable bacteria and showed a larger thickness in SEM photographs than those of P. gingivalis ATCC 33277. The antibiotics tested showed different efficacy for the different strains. Moxifloxacin was the most efficient antibiotic: onefold MIC was sufficient to eliminate A. actinomycetemcomitans Y4 and P. gingivalis ATCC 33277 after 48 h. However, only the 50-fold MIC completely eradicated S. constellatus 384b. SEM photographs underlined the damaging effect of moxifloxacin on the biofilm structure. CONCLUSION:The complete removal of bacteria by the use of antibiotics alone seems to be impossible when taking into account MIC values and the level of antibiotics in gingival fluid.
journal_name
J Clin Periodontoljournal_title
Journal of clinical periodontologyauthors
Eick S,Seltmann T,Pfister Wdoi
10.1111/j.0303-6979.2004.00490.xkeywords:
subject
Has Abstractpub_date
2004-05-01 00:00:00pages
376-83issue
5eissn
0303-6979issn
1600-051Xpii
CPE490journal_volume
31pub_type
杂志文章abstract：FOCUSED QUESTION:What is the clinical influence of probiotics as an adjunctive therapy of scaling and root planing (SRP) when compared with SRP alone or in combination with placebo in the treatment of chronic periodontitis (CP). METHODS:Electronic databases were searched up to July 2015. Randomized controlled trials (...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章,meta分析,评审
doi：10.1111/jcpe.12545
更新日期：2016-06-01 00:00:00
abstract：AIM:The aim of this study was to determine the association between periodontitis and the incidence of preterm birth (PB), low birth weight (LBW) and preterm low birth weight (PLBW) MATERIAL AND METHODS: One thousand and ninety-six women were enrolled. Periodontal data, pregnancy outcome variables and information on oth...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051X.2007.01166.x
更新日期：2008-01-01 00:00:00
abstract：OBJECTIVES:The aim of this study was to investigate the postoperative healing and microbial profile of donor sites of routine and pre-wounded free gingival grafts (FGGs). METHODS:Ten volunteers, recruited into a split mouth study, had one side of the palate pre-wounded. Five days later, grafts were harvested from both...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/jcpe.12494
更新日期：2016-03-01 00:00:00
abstract：BACKGROUND:Treatment of localized aggressive periodontitis (LAP) may include systemic antibiotics, yet it is unclear at what stage of treatment planning antibiotics are most effective. AIM:This retrospective analysis compared immediate versus delayed antibiotic therapy on clinical parameters and gingival crevicular fl...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/jcpe.12001
更新日期：2012-11-01 00:00:00
abstract：:This study examines the incidence and severity of postoperative pain after gingivectomy using one non-eugenol-containing periodontal dressing, Coe-pak (n = 76) and 2 eugenol-containing periodontal dressings, Wondrpak (n = 64) and Nobetec (n = 86). All patients were subjected to gingivectomy using 1 type of local anaes...
journal_title：Journal of clinical periodontology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1111/j.1600-051x.1990.tb00028.x
更新日期：1990-07-01 00:00:00
abstract：OBJECTIVES:The aim of this case-control study was to ascertain if women who experienced a preterm (or premature) birth had any differences in periodontal disease severity compared with women who delivered at term. MATERIAL AND METHODS:Subjects were recruited postpartum. Case subjects delivered a baby before 37 weeks o...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051X.2004.00598.x
更新日期：2005-01-01 00:00:00
abstract：BACKGROUND, AIMS:Zinc-citrate-containing toothpastes have previously been suggested to be of value at inhibiting plaque and gingival inflammation. Present formulations have included triclosan which is thought to contribute major antibacterial/antiplaque effects. Alternative antimicrobial agents and other ingredients su...
journal_title：Journal of clinical periodontology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1034/j.1600-051x.2001.028002157.x
更新日期：2001-02-01 00:00:00
abstract：AIM:The aim of this study was to compare short- and long-term root coverage and aesthetic outcomes of the coronally advanced flap (CAF) alone or in combination with a connective tissue graft (CTG) for the treatment of multiple gingival recessions. METHODS:Fifty patients with multiple (≥2) adjacent gingival recessions ...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章,随机对照试验
doi：10.1111/jcpe.12224
更新日期：2014-04-01 00:00:00
abstract：BACKGROUND:Chlorhexidine (CHX) 0.2% solution, still the golden standard as mouthrinse for the prevention of plaque formation and development of gingivitis, has some limited side-effects such as extrinsic tooth staining, poor taste, taste disturbance, sensitivity changes in tongue, pain, and the content of alcohol. Thes...
journal_title：Journal of clinical periodontology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1034/j.1600-051x.2001.281207.x
更新日期：2001-12-01 00:00:00
abstract：OBJECTIVES:The purpose of this study was to elucidate whether the association between beta-3 adrenergic receptor polymorphism and periodontal disease is modified by body weight. MATERIAL AND METHODS:We enrolled 332 postmenopausal women and determined their HbA1C levels (%) and beta-3 adrenergic receptor (rs4994) genot...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/jcpe.12235
更新日期：2014-05-01 00:00:00
abstract：AIMS:The objective of this study was to characterize the inhibitory effects of Weissella cibaria isolates on volatile sulphur compounds (VSC) production both in vitro and in vivo. MATERIAL AND METHODS:We isolated and identified three hydrogen peroxide-generating lactobacilli from children's saliva, and assessed their ...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051X.2006.00893.x
更新日期：2006-03-01 00:00:00
abstract：OBJECTIVES:Safety and efficacy of glycine powder air-polishing (GPAP) in removing subgingival biofilm have been previously demonstrated. The hypothesis that GPAP results in less gingival erosion than sodium bicarbonate air-polishing (SBAP) or hand-instrumentation was assessed. MATERIAL AND METHODS:In each of 10 patien...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章,随机对照试验
doi：10.1111/j.1600-051X.2007.01195.x
更新日期：2008-04-01 00:00:00
abstract：PURPOSE:To investigate the amount of the mineralization of a bovine bone substitute material in sinus floor augmentation after healing times of 3 and 6 months. MATERIALS AND METHODS:Fifty-one patients were randomized into two healing time groups and received sinus floor augmentations with a bovine bone material. After...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章,随机对照试验
doi：10.1111/jcpe.12466
更新日期：2015-11-01 00:00:00
abstract：OBJECTIVE:This study evaluates whether or not, among other factors, membrane-coverage of antrostomy defects improves implant survival in sinus augmentation procedures. MATERIALS AND METHODS:We performed a two-arm and split-mouth randomized controlled clinical trial on 104 and 5 patients respectively. In the two-arm st...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章,随机对照试验
doi：10.1111/jcpe.12153
更新日期：2013-11-01 00:00:00
abstract：AIM:To test the hypothesis that a synthetic hydroxyapatite/β-tricalcium phosphate (HA/TCP) construct combined with polyethylene glycol (PEG) hydrogel including recombinant human bone morphogenetic proteins-2 (rhBMP-2) enhances new bone formation compared with bone morphogenetic proteins-2 (BMP-2) delivered using the HA...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/jcpe.12264
更新日期：2014-08-01 00:00:00
abstract：:There have been some reports that folic acid inhibits phenytoin-induced gingival hyperplasia. The purpose of this double-blind study was to quantify clinically the effects of both systemic and topical administration of folic acid on phenytoin-induced gingival overgrowth in man. For a period of 6 months, one group of p...
journal_title：Journal of clinical periodontology
pub_type： 临床试验,杂志文章
doi：10.1111/j.1600-051x.1987.tb00983.x
更新日期：1987-07-01 00:00:00
abstract：AIM:The purpose of this study was to evaluate the relationship between periodontal disease and general health status in community-dwelling elderly using serum albumin concentration as a criterion index of the severity of an underlying disease and nutrition status. METHODS:Serum albumin level was detected by the bromcr...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051X.2005.00901.x
更新日期：2006-05-01 00:00:00
abstract：AIM:The aim of this study was to assess the use of a micro-brush to remove plaque deposits from subgingival, periodontally involved root surfaces in vivo. METHODS:30 periodontally involved teeth requiring extraction for periodontal or prosthetic reasons in 26 adult patients were utilised. For inclusion, teeth had to d...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1034/j.1600-051x.2001.028009820.x
更新日期：2001-09-01 00:00:00
abstract：BACKGROUND AND PURPOSE:Periodontal maintenance is critical for the long-term success of prosthodontic treatment. This study investigates the validity of questionnaires/models in monitoring periodontitis for Chinese prosthodontic patients. METHODS:In total, 114 patients completed the questionnaire. The chi-squared test...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/jcpe.12103
更新日期：2013-06-01 00:00:00
abstract：AIM:In this study, we investigated the effect of differences in periodontal status in the masticatory performance of dentate subjects with the same occlusal supporting area. MATERIALS AND METHODS:The subjects of the analysis were classified into those of Eichner A1-3 (n = 1094) and Eichner B1-4 (n = 529). Subjects' pe...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/jcpe.12241
更新日期：2014-05-01 00:00:00
abstract：:The present study was designed to examine if alveolar bone, located adjacent to a root surface deprived of its periodontal ligament and cementum layer, can stimulate the reformation of a connective tissue attachment. The maxillary and mandibular incisors in 3 monkeys were extracted. Immediately after tooth extraction,...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051x.1984.tb01306.x
更新日期：1984-01-01 00:00:00
abstract：AIM:There is a paucity of up-to-date data regarding prevalence and risk indicators of periodontitis in Italy. Therefore, the aim of this study was to evaluate the prevalence of periodontitis and its risk indicators among adults from an urban area in North Italy. MATERIAL AND METHODS:This cross-sectional survey used a ...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/jcpe.12420
更新日期：2015-07-01 00:00:00
abstract：AIM:The aim of this study was to determine the prevalence and the structure of the leukotoxin promoter region of Actinobacillus actinomycetemcomitans in an ethnic Chinese population. METHOD:Subgingival plaque samples were collected from 42 patients with moderate to advanced periodontitis and 50 periodontally healthy p...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1034/j.1600-051x.2001.028009886.x
更新日期：2001-09-01 00:00:00
abstract：OBJECTIVES:To evaluate the efficacy of subgingival instrumentation (PICOS-1), sonic/ultrasonic/hand instruments (PICOS-2) and different subgingival instrumentation delivery protocols (PICOS-3) to treat periodontitis. METHODS:Systematic electronic search (CENTRAL/MEDLINE/EMBASE/SCOPUS/LILACS) to March 2019 was conducte...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章,评审
doi：10.1111/jcpe.13245
更新日期：2020-07-01 00:00:00
abstract：:The present investigation attempted to determine if the pattern of past periodontal destruction could be concisely summarized, and related to other clinical and microbiological parameters. 61 subjects between the ages of 12 and 61 years with destructive periodontal disease were evaluated at 6 sites per tooth for redne...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051x.1986.tb00856.x
更新日期：1986-07-01 00:00:00
abstract：BACKGROUND:While there seems to be a common belief that psychosocial stress affects oral hygiene behavior, this assumption has rarely been proved. The present study thus aims to analyse stress effects on oral hygiene. MATERIAL AND METHODS:16 matched pairs of medical students each consisting of 1 student participating ...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1034/j.1600-051x.2001.028005459.x
更新日期：2001-05-01 00:00:00
abstract：:Staining of teeth and mucous membranes is a well-known side-effect with chlorhexidine mouthrinses in which dietary chromogens play an important rôle. The purpose of this study was to determine whether a co-polymer anti-adhesive agent would prevent staining by a low concentration chlorhexidine solution. Additionally, t...
journal_title：Journal of clinical periodontology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1111/j.1600-051x.1995.tb01796.x
更新日期：1995-12-01 00:00:00
abstract：AIM:To evaluate the safety and efficacy of autologous periodontal ligament-derived mesenchymal stem cells (PDL-MSCs) embedded in a xenogeneic bone substitute (XBS) for the regenerative treatment of intra-bony periodontal defects. MATERIAL AND METHODS:This quasi-randomized controlled pilot phase II clinical trial inclu...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/jcpe.13368
更新日期：2020-11-01 00:00:00
abstract：OBJECTIVES:The objective of this study was to investigate the association of body composition (obesity) and periodontal disease using simple, inexpensive nutritional assessment techniques available in the Third National Health and Nutrition Examination Survey (NHANES III). MATERIAL AND METHODS:Caucasian subjects, aged...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1034/j.1600-051x.2003.00353.x
更新日期：2003-04-01 00:00:00
abstract：OBJECTIVE:To compare two sonic toothbrushes in relation to the reversal of experimental gingivitis. MATERIALS AND METHODS:Subjects refrained from brushing mandibular teeth for 21 days. During a 4-week treatment phase, the right or left side of the mouth was brushed with either the Sonic Complete (SC) or Sonicare Elite...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章,随机对照试验
doi：10.1111/j.1600-051X.2005.00851.x
更新日期：2005-12-01 00:00:00
