Evidence for a Na-K-ATPase-inhibitor in erythrocytes of patients with essential hypertension.

abstract：BACKGROUND:We have investigated the potential for using antisense technology as a means of delivering treatment for acute myeloblastic leukaemia (FAB-M2) by gene therapy. MATERIALS AND METHODS:A test recombinant adenovirus vector was constructed containing human c-myc antisense fragments to study the effects of alteri...

journal_title：European journal of clinical investigation

authors： Chen JP,Chen L,Leek J,Lin C

更新日期：2006-01-01 00:00:00

abstract：:Insulin resistance has been reported in normal ageing but discrepancies between such studies may be related to compounding factors such as body composition and exercise patterns. We employed a two-step hyperinsulinaemic euglycaemic clamp to assess peripheral and hepatic tissue insulin sensitivity and glucose recycling...

journal_title：European journal of clinical investigation

authors： Broughton DL,James OW,Alberti KG,Taylor R

更新日期：1991-02-01 00:00:00

abstract：BACKGROUND:The detection of important immunocompetence-like features on endocrine steroid cells raises questions about direct intercellular communication between the adrenal and immune systems. This article summarizes our recent work and new data on immune-adrenal interactions. MATERIALS AND METHODS:RT-PCR and immunoh...

journal_title：European journal of clinical investigation

authors： Marx C,Bornstein SR,Wolkersdörfer GW

更新日期：2000-12-01 00:00:00

abstract：BACKGROUND:Fat tissue is a common material for autologous transplantation in plastic and reconstructive surgery. Basic fibroblast growth factor (bFGF) ameliorates the fat graft survival. A transplantation model has shown the gene expression of matrix metalloproteinases (MMPs) to increase in adipocytes. The aim of this ...

journal_title：European journal of clinical investigation

authors： Kuramochi D,Unoki H,Bujo H,Kubota Y,Jiang M,Rikihisa N,Udagawa A,Yoshimoto S,Ichinose M,Saito Y

更新日期：2008-10-01 00:00:00

abstract：:Activities of urea cycle enzymes were measured in the liver of starved rats 12 and 48 h after bilateral nephrectomy. Control experiments (sham-operated, starved rats) revealed that the activities of only two enzymes of the cycle are altered in the uraemic state: argininosuccinic acid synthetase (EC 6.3.4.5.), which is...

journal_title：European journal of clinical investigation

authors： Hoppe-Seyler G

更新日期：1975-02-01 00:00:00

abstract：BACKGROUND:Lipoprotein(a) [Lp(a)] is an atherothrombotic plasma lipoprotein with unknown function. Little is known about the catabolism of this lipoprotein, in particular the steps related to apolipoprotein(a) [apo(a)] fragmentation and excretion by the kidney. MATERIAL AND METHODS:High plasma levels (up to 9 mg dL(-1...

journal_title：European journal of clinical investigation

authors： Frank S,Hrzenjak A,Blaschitz A,Dohr G,Kostner GM

更新日期：2001-06-01 00:00:00

abstract：:Eur J Clin Invest 2012; 42 (6): 579-588 ABSTRACT: Glucose-based methods are currently gold standards for identifying individuals at risk of type 2 diabetes. Obviously, these methods only consider one of many pathologies of impaired glucose metabolism and they all suffer from a poor specificity as type 2 diabetes risk ...

journal_title：European journal of clinical investigation

authors： Gjesing AP,Pedersen O

更新日期：2012-06-01 00:00:00

abstract：:The concentrations of gastrins containing the active C-terminal tetrapeptide amide (mainly gastrin-34 and gastrin-17) and the N-terminal tridecapeptide fragment of gastrin-17 were measured in antral and duodenal biopsy specimens. The antral concentration of the N-terminal gastrin fragment was much higher in patients w...

journal_title：European journal of clinical investigation

authors： Petersen B,Andersen BN

更新日期：1984-06-01 00:00:00

abstract：:Inflammation is a well-coordinated process in response to tissue injury or infection aimed at restoration of tissue homoeostasis. Platelets and neutrophils are typically viewed important in the context of haemostasis and bacterial killing, respectively. However, as these cells are equipped with readily available armou...

journal_title：European journal of clinical investigation

authors： Soehnlein O

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Glomerulonephritis clusters in families. However, infections are common inducers of glomerulonephritis and may also cluster in families. Studies of adoptees and their biological and adoptive parents may disentangle genetic from environmental causes of familial clustering. This is the first adoption study aim...

journal_title：European journal of clinical investigation

authors： Akrawi DS,Zöller B,Fjellstedt E,Sundquist J,Sundquist K,PirouziFard M

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Thyroid feedback regulation and equilibria between thyroid hormones differ in the presence or absence of a functioning thyroid remnant. MATERIALS AND METHODS:This study examines the relationship between the sensitivity of TSH feedback and thyroid capacity in untreated patients with thyroid autoimmune diseas...

journal_title：European journal of clinical investigation

authors： Hoermann R,Midgley JEM,Larisch R,Dietrich JW

更新日期：2018-10-01 00:00:00

abstract：:The in vivo metabolism in the rat of radioiodinated human and rat high-density lipoprotein was compared with a double-label procedure using 125I and 131I. While rat high-density lipoprotein showed a biphasic serum decay, human high-density lipoprotein was characterized by a monoexponential serum decay. No differences ...

journal_title：European journal of clinical investigation

authors： van't Hooft FM,van Tol A

更新日期：1985-12-01 00:00:00

abstract：:Inheritance is a major determinant of increased sodium-lithium countertransport (SLC) activity in hypertension. However, hyperlipidaemia can also cause increased SLC activity in some individuals and it is difficult to distinguish this effect from the effect of hypertension. Erythrocyte SLC activity and its kinetic det...

journal_title：European journal of clinical investigation

authors： Rutherford PA,Thomas TH,Laker MF,Wilkinson R

更新日期：1992-11-01 00:00:00

abstract：:Adequate pregnancy care of women with systemic lupus erythematosus (SLE) rests on three pillars: a coordinated medical-obstetrical care, an agreed and well-defined management protocol and a good neonatal unit. Pregnancy should be planned following a preconceptional visit for counselling. Women with severe active disea...

journal_title：European journal of clinical investigation

authors： Ruiz-Irastorza G,Khamashta MA

更新日期：2011-06-01 00:00:00

abstract：:In controls and in patients suffering from congestive heart failure (CHF) the circulating levels of catecholamines, neuropeptide Y-like immunoreactivity (NPY-LI), vasoactive intestinal peptide-LI (VIP-LI), substance P-LI (SP-LI) and calcitonin generated peptide-LI (CGRP-LI) markers of sympathetic, parasympathetic and ...

journal_title：European journal of clinical investigation

authors： Edvinsson L,Ekman R,Hedner P,Valdemarsson S

更新日期：1990-02-01 00:00:00

abstract：BACKGROUND:Renal cyclooxygenases (COX) produce the prostaglandins (PG) E2, I2 and thromboxane (TxA2), which interact with distinct G protein-coupled receptors. We investigated the expression of the three EP receptors EP2, EP3 and EP4 and the receptors for PGI2 (IP) and TxA2 (TP) in rats with passive Heymann nephritis (...

journal_title：European journal of clinical investigation

authors： Waldner C,Heise G,Schrör K,Heering P

更新日期：2003-11-01 00:00:00

abstract：:To determine the comparative value of serum Type III procollagen peptide (PIIIP) in paediatric and adult liver disease we have measured PIIIP in 201 healthy subjects (aged 1 day-77 years) and twenty-one children and five adults with chronic active hepatitis (CAH). Healthy children had significantly higher PIIIP levels...

journal_title：European journal of clinical investigation

authors： Trivedi P,Cheeseman P,Portmann B,Hegarty J,Mowat AP

更新日期：1985-04-01 00:00:00

abstract：BACKGROUND:The investigation of the human follicle fluid proteome has gained much interest in the search of new markers as predictors for in vitro fertilization and intracytoplasmic sperm injection (IVF/ICSI) treatment outcome. Follicular fluid folate, as substrate of one carbon (1-C) metabolism, affects follicular met...

journal_title：European journal of clinical investigation

authors： Twigt JM,Bezstarosti K,Demmers J,Lindemans J,Laven JS,Steegers-Theunissen RP

更新日期：2015-08-01 00:00:00

abstract：:The classical view of aldosterone actions via the mineralocorticoid receptor (MR) limited to control of fluid balance and blood pressure homoeostasis has been progressively overcome by clinical and experimental evidence emphasizing the pleiotropic role of MR activation in the pathogenesis of cardiovascular disease. Cl...

journal_title：European journal of clinical investigation

authors： Galuppo P,Bauersachs J

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:Acute myocardial infarction (AMI) is followed by post AMI cardiac remodelling, often leading to congestive heart failure. Homing of c-kit+ endothelial progenitor cells (EPC) has been thought to be the optimal source for regenerating infarcted myocardium. METHODS:Immune function of viable peripheral blood mo...

journal_title：European journal of clinical investigation

authors： Ankersmit HJ,Hoetzenecker K,Dietl W,Soleiman A,Horvat R,Wolfsberger M,Gerner C,Hacker S,Mildner M,Moser B,Lichtenauer M,Podesser BK

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:Bleeding time has been reported to increase during gaseous nitric oxide (NO) inhalation in healthy volunteers and patients, and it has been speculated that inhaled NO inhibits platelet function. However, results have not been unanimous, and we have been unable to document any effects of inhaled NO on circula...

journal_title：European journal of clinical investigation

authors： Albert J,Norman M,Wallén NH,Frostell C,Hjemdahl P

更新日期：1999-11-01 00:00:00

abstract：:Based on pathophysiological findings Lp(a) is considered to be a cardiovascular risk factor. The Göttingen Risk Incidence and Prevalence Study (GRIPS) provides the possibility to evaluate this impact of Lp(a) on the basis of a large prospective cohort study. GRIPS included 6002 men, aged 40-59.9 years at baseline. Dat...

journal_title：European journal of clinical investigation

authors： Cremer P,Nagel D,Labrot B,Mann H,Muche R,Elster H,Seidel D

更新日期：1994-07-01 00:00:00

abstract：:The effect of renal function on the cyclic AMP (cAMP) response to exogenous parathyroid hormone (PTH) was examined in patients with chronic renal failure (n = 22) and primary hyperparathyroidism (n = 19). In the patients with chronic renal failure there was marked resistance to the effect of exogenous PTH. In primary ...

journal_title：European journal of clinical investigation

authors： Lewin IG,Hendy GN,Papapoulos SE,Tomlinson S,O'Riordan JL

更新日期：1985-02-01 00:00:00

abstract：:Basal cyclic AMP levels in blood mononuclear cells from healthy human donors has been studied. A great variation in cyclic AMP content ranging from below 2 to 20 pmol 10(-6) cells was seen. Incubation of the cells at 37 degrees C mostly showed a time-dependent decrease in basal cyclic AMP, levelling off after 16 h. Wh...

journal_title：European journal of clinical investigation

authors： Svenson M,Permin H,Wiik A

更新日期：1984-08-01 00:00:00

abstract：:Anaemia is a common condition among pre-end-stage renal disease (pre-ESRD) patients with chronic kidney disease (CKD). Indeed, data from clinical studies indicate that anaemia may be present in as many as two-thirds of such patients. Use of recombinant human erythropoietin (EPO) provides an effective means of correcti...

journal_title：European journal of clinical investigation

authors： McClellan WM,Jurkovitz C,Abramson J

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:Subclinical hypothyroidism may adversely affect the development of cardiovascular disease (CVD). Less is known about the role of low-normal thyroid function, that is higher thyroid-stimulating hormone and/or lower free thyroxine levels within the euthyroid reference range, in the development of cardio-metabo...

journal_title：European journal of clinical investigation

authors： van Tienhoven-Wind LJ,Dullaart RP

更新日期：2015-05-01 00:00:00

abstract：:We have examined the impact of race and positive family history of type 2 diabetes on glucose/insulin dynamics and the two components of glucose disposal in healthy, first-degree relatives of black and white American patients with type 2 diabetes mellitus who are at a greater risk from the disease and their healthy co...

journal_title：European journal of clinical investigation

authors： Osei K,Cottrell DA

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND:Pseudoxanthoma elasticum (PXE), a rare heritable disorder caused by mutations of the ABCC6 gene, is characterized by fragmentation and mineralization of elastic fibres. We determined the extent of degradation of elastin by measuring and comparing the amount of desmosines in plasma and urine of PXE patients, ...

journal_title：European journal of clinical investigation

authors： Annovazzi L,Viglio S,Gheduzzi D,Pasquali-Ronchetti I,Zanone C,Cetta G,Iadarola P

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND:  Cirrhotic patients are at considerable risk for bacterial infections, possibly through increased intestinal permeability and bacterial overgrowth. Proton pump inhibitors (PPIs) may increase infection risk. We aimed to explore the potential association between PPI use and bacterial infection risk in cirrhot...

journal_title：European journal of clinical investigation

authors： van Vlerken LG,Huisman EJ,van Hoek B,Renooij W,de Rooij FW,Siersema PD,van Erpecum KJ

更新日期：2012-07-01 00:00:00

abstract：:The effects of glucose on the cytoplasmic Ca2+ concentration (Ca2+i) regulating insulin release were investigated using pancreatic beta-cells representative for the normal and diabetic situations. Increase of the glucose concentration resulted in a slight lowering of Ca2+i followed by a rise, often manifested as high ...

journal_title：European journal of clinical investigation

authors： Hellman B,Berne C,Grapengiesser E,Grill V,Gylfe E,Lund PE

更新日期：1990-10-01 00:00:00