Cellular immune-endocrine interaction in adrenocortical tissues.

abstract：BACKGROUND:Lipoprotein(a) [Lp(a)] is an important cardiovascular risk factor in the general population. However, prospective data on the vascular risk conferred by Lp(a) in patients with diabetes mellitus are scarce and controversial. It is not known whether the diabetic state affects the association of Lp(a) with vasc...

journal_title：European journal of clinical investigation

authors： Saely CH,Koch L,Schmid F,Marte T,Aczel S,Langer P,Hoefle G,Drexel H

更新日期：2006-02-01 00:00:00

abstract：:The concentration in serum of cathodal trypsinogen has been studied in certain clinical and experimental situations. The concentration correlated with pancreatic amylase activity. Low levels were found in patients with malabsorption due to exocrine pancreatic insufficiency. The concentration rose after endoscopic retr...

journal_title：European journal of clinical investigation

authors： Borgström A,Ohlsson K

更新日期：1978-12-01 00:00:00

abstract：:Skeletal muscle glycogen deposition, and the activation of muscle glycogen synthase and pyruvate dehydrogenase during a hyerinsulinaemic euglycaemic clamp have been measured in six young and six elderly males matched for body mass index, physical activity and diet. Clamp glucose requirement (insulin, 0.1 U kg-1 h-1) w...

journal_title：European journal of clinical investigation

authors： Kruszynska YT,Petranyi G,Alberti KG

更新日期：1988-10-01 00:00:00

abstract：BACKGROUND:In mutations of the low-density lipoprotein (LDL) receptor gene, the defect of internalization is caused by a mutation in the cytoplasmic domain of the receptor linked with exons 17 and 18, and the O-linked sugar domain linked with exon 15 has been speculated not to affect the function of the receptor. Here,...

journal_title：European journal of clinical investigation

authors： Tashiro J,Endo M,Bujo H,Shinomiya M,Morisaki N,Saito Y

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND:A broad spectrum of hepatobiliary disorders are found in patients with inflammatory bowel diseases. The aim of the present work was to study interactions between gut and liver in experimental rat models of colitis and small bowel inflammation. MATERIALS AND METHODS:Colitis was induced either by trinitrobenz...

journal_title：European journal of clinical investigation

authors： Dikopoulos N,Schmid RM,Bachem M,Buttenschoen K,Adler G,Chiang JY,Weidenbach H

更新日期：2007-03-01 00:00:00

abstract：:Combined 47Calcium kinetic and calcium balance studies with correction for dermal calcium loss were performed in thirteen patients with primary hyperparathyroidism (PHP), in whom serum bone-Gla-protein (S-BGP) was measured, and in ten matched controls. Dietary calcium was normal in PHP but both net (7.9 +/- 1.4 mmol C...

journal_title：European journal of clinical investigation

authors： Charles P,Mosekilde L,Jensen FT

更新日期：1986-08-01 00:00:00

abstract：BACKGROUND:Cold ischaemic (CI) injury is associated with reduced renal graft function and survival. However, there is little evidence on the benefits of reducing CI injury within a 24 h period in donation after cardiac death (DCD) kidney transplantation. METHODS:Porcine kidneys subjected to 10-min warm ischaemia were ...

journal_title：European journal of clinical investigation

authors： Hosgood SA,Bagul A,Nicholson ML

更新日期：2011-03-01 00:00:00

abstract：:To examine the possible effects of hyperoxalaemia on anaerobic metabolism and erythrocyte pyruvate kinase activity, we induced a rise in plasma oxalate in 11 dialysis patients by the oral administration of ascorbic acid, 500 mg day-1 for 3 weeks. Blood samples were taken from the same antecubital vein before and after...

journal_title：European journal of clinical investigation

authors： Tomson CR,Channon SM,Ward MK,Laker MF

更新日期：1990-08-01 00:00:00

abstract：:The clinical and physiological relevance of the relationship between gastrin and calcitonin has been investigated in normal subjects and in patients suffering from gastritis or duodenal ulcer. Basal plasma levels of calcitonin are increased in these patients but there is no significant relationship between calcitonin ...

journal_title：European journal of clinical investigation

authors： Heynen G,Brassine A,Daubresse JC,Ligny G,Kanis JA,Gaspar S,Franchimont P

更新日期：1981-08-01 00:00:00

abstract：:Inheritance is a major determinant of increased sodium-lithium countertransport (SLC) activity in hypertension. However, hyperlipidaemia can also cause increased SLC activity in some individuals and it is difficult to distinguish this effect from the effect of hypertension. Erythrocyte SLC activity and its kinetic det...

journal_title：European journal of clinical investigation

authors： Rutherford PA,Thomas TH,Laker MF,Wilkinson R

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND:Neutrophil-mediated inflammation was recently identified as an active contributor to athero-progression. Therapeutic strategies inhibiting neutrophil degranulation or recruitment were hypothesized to positively impact on plaque vulnerability. In this study, we investigated whether treatment with the recently...

journal_title：European journal of clinical investigation

authors： Da Silva AR,Lenglet S,Carbone F,Burger F,Roth A,Liberale L,Bonaventura A,Dallegri F,Stergiopulos N,Santos RA,Mach F,Fraga-Silva RA,Montecucco F

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Clusterin (Apolipoprotein J), a plasma protein with cytoprotective and complement-inhibiting activities, localizes in the infarcted heart during myocardial infarction (MI). Recently, we have shown a protective effect of exogenous clusterin in vitro on ischaemically challenged cardiomyocytes independent of co...

journal_title：European journal of clinical investigation

authors： Van Dijk A,Vermond RA,Krijnen PA,Juffermans LJ,Hahn NE,Makker SP,Aarden LA,Hack E,Spreeuwenberg M,van Rossum BC,Meischl C,Paulus WJ,Van Milligen FJ,Niessen HW

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVE:N(ε)-(carboxymethyl)lysine (CML) is one of the major advanced glycation end products in both diabetics and nondiabetics. CML depositions in the microvasculature have recently been linked to the aetiology of acute myocardial infarction and cognitive impairment in Alzheimer's disease, possibly related to local ...

journal_title：European journal of clinical investigation

authors： Fuijkschot WW,de Graaff HJ,Berishvili E,Kakabadze Z,Kupreishvili K,Meinster E,Houtman M,van Broekhoven A,Schalkwijk CG,Vonk AB,Krijnen PA,Smulders YM,Niessen HW

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Buerger's disease (BD) is a segmental occlusive vascular disease. The aim of this study was to detect functional changes in brachial artery and asymptomatic morphological changes in extra-cranial carotid arteries not affected by the disease process and to assess markers of inflammation and endothelial damage...

journal_title：European journal of clinical investigation

authors： Joras M,Poredos P,Fras Z

更新日期：2006-06-01 00:00:00

abstract：:The cellular mechanisms controlling adaptive intestinal mucosal hypo- and hyperplasia are poorly understood but changes in tissue polyamine levels and in the activity of the key enzymes controlling their synthesis (ornithine decarboxylase: ODC) and degradation (diamine oxidase: DAO) have been implicated. Therefore, in...

journal_title：European journal of clinical investigation

authors： Hosomi M,Stace NH,Lirussi F,Smith SM,Murphy GM,Dowling RH

更新日期：1987-10-01 00:00:00

abstract：:The most well characterized function of pulmonary surfactant is its ability to reduce surface tension at the alveolar air-liquid interface, thereby preventing lung collapse. However, several lines of evidence suggest that surfactant may also have 'non-surfactant' functions: specific components of surfactant (proteins ...

journal_title：European journal of clinical investigation

authors： Pison U,Max M,Neuendank A,Weissbach S,Pietschmann S

更新日期：1994-09-01 00:00:00

abstract：:Investigations have been carried out to explain the heterogeneity of response to catecholamines of human fat cells from various deposits. Adipocytes from two subcutaneous sites (abdominal and femoral) were studied concomitantly in women while omental fat cells were taken from another group of patients undergoing abdom...

journal_title：European journal of clinical investigation

authors： Mauriege P,Galitzky J,Berlan M,Lafontan M

更新日期：1987-04-01 00:00:00

abstract：BACKGROUND:In vitro fertilisation (IVF) has been widely used during the last decades. Recent studies demonstrated some alterations in IVF children's metabolic profile compared with controls. The recently reported lipocalins retinol-binding protein 4 (RBP-4) and neutrophil gelatinase-associated lipocalin (NGAL), as well...

journal_title：European journal of clinical investigation

authors： Sakka SD,Margeli A,Loutradis D,Chrousos GP,Papassotiriou I,Kanaka-Gantenbein C

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:The sympathetic nervous exerts a key role in cardiovascular homeostasis control by regulating cardiac output, systemic vascular resistance, heart rate and blood pressure. MATERIALS AND METHODS:Data collected during the past 30 years have unequivocally shown that in a considerable number of cardiovascular as...

journal_title：European journal of clinical investigation

authors： Grassi G,Seravalle G,Mancia G

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Several clinical trials have suggested that a metabolic cocktail of glucose-insulin-potassium (GIK) decreases mortality rates in patients with acute myocardial infarction (AMI). It has also been reported that Fas-mediated apoptosis plays an important role in ischaemic/reperfusion injury in the rat model. Thi...

journal_title：European journal of clinical investigation

authors： Zhang L,Zhang L,Li YH,Zhang HY,Chen ML,Gao MM,Hu AH,Yang HS,Yang HS

更新日期：2005-03-01 00:00:00

abstract：:The in situ intraperitoneal volume and the mass transfer area coefficients (MTC) of urea, lactate, creatinine, glucose, kanamycin, inulin, beta 2-microglobulin, albumin and IgG were studied in eight continuous ambulatory peritoneal dialysis (CAPD) patients. All patients were studied during a 4-h dialysis dwell, first ...

journal_title：European journal of clinical investigation

authors： Krediet RT,Zuyderhoudt FM,Boeschoten EW,Arisz L

更新日期：1987-02-01 00:00:00

abstract：:Levels of free anti-(xanthine oxidoreductase) (XOR) antibodies in the serum of normal healthy human subjects were determined, using both human and bovine enzyme as antigen, in an enzyme-linked immunosorbent assay (ELISA). Levels of IgM class anti-(human XOR) antibodies were found to be particularly high (mean values r...

journal_title：European journal of clinical investigation

authors： Benboubetra M,Gleeson A,Harris CP,Khan J,Arrar L,Brennand D,Reid J,Reckless JD,Harrison R

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND:Arterial calcification (AC) is a major health problem associated with extreme morbidity and a shortened survival. It is currently without any effective treatment. ATP and the purinergic system in general are now emerging as being important in the pathogenesis of AC and potentially provide a new focus for nov...

journal_title：European journal of clinical investigation

authors： Fish RS,Klootwijk E,Tam FW,Kleta R,Wheeler DC,Unwin RJ,Norman J

更新日期：2013-04-01 00:00:00

abstract：:Lipid and carbohydrate metabolism variables were studied in twenty-eight patients with chronic renal failure (mean GFR 7.7 +/- 2.5 ml/min) and uraemic symptoms. 71% of the patients had hypertriglyceridaemia (greater than or equal to 2.2 mmol/l). Total serum cholesterol was normal while VLDL cholesterol was high and al...

journal_title：European journal of clinical investigation

authors： Attman PO,Gustafson A

更新日期：1979-08-01 00:00:00

abstract：:The effect of renal function on the cyclic AMP (cAMP) response to exogenous parathyroid hormone (PTH) was examined in patients with chronic renal failure (n = 22) and primary hyperparathyroidism (n = 19). In the patients with chronic renal failure there was marked resistance to the effect of exogenous PTH. In primary ...

journal_title：European journal of clinical investigation

authors： Lewin IG,Hendy GN,Papapoulos SE,Tomlinson S,O'Riordan JL

更新日期：1985-02-01 00:00:00

abstract：:Propranolol is used clinically as a prophylactic drug to prevent oesophageal variceal bleeding in cirrhotic patients with portal hypertension. Vascular hyporesponsiveness is a common characteristic of the portal hypertensive state. The present study aimed to investigate whether chronic administration of propranolol co...

journal_title：European journal of clinical investigation

authors： Huang YT,Lin HC,Tsai JF,Hou MC,Hong CY

更新日期：1997-07-01 00:00:00

abstract：:Resealed erythrocytes are potential slow release carriers for drugs and enzymes. We have investigated carrier erythrocyte survival in human volunteers using gentamicin (G) as encapsulated cell marker; G was readily incorporated into red cells by hypo-osmotic dialysis (87% efficiency of incorporation) and did not exit ...

journal_title：European journal of clinical investigation

authors： Eichler HG,Rameis H,Bauer K,Korn A,Bacher S,Gasić S

更新日期：1986-02-01 00:00:00

abstract：BACKGROUND:Gastroesophageal reflux disease (GERD), including erosive reflux disease and non-erosive reflux disease (NERD), is a chronic disease with a significant negative effect on quality of life. State-of-the-art treatment involves proton pump inhibitors (PPIs). However, relapse of symptoms occurs in the majority of...

journal_title：European journal of clinical investigation

authors： Compare D,Pica L,Rocco A,De Giorgi F,Cuomo R,Sarnelli G,Romano M,Nardone G

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:Kinetic abnormalities of apolipoprotein B (apoB)-containing lipoproteins in noninsulin-dependent diabetes mellitus (NIDDM) remain poorly understood. To get further insight into these abnormalities we performed a stable isotope kinetic experiment comparing the metabolism of apoB-containing lipoproteins in mod...

journal_title：European journal of clinical investigation

authors： Duvillard L,Pont F,Florentin E,Galland-Jos C,Gambert P,Vergès B

更新日期：2000-08-01 00:00:00

abstract：BACKGROUND:Chronic hyperglycaemia in diabetes is suggested to be a major cause of diabetic angiopathy. Up until now, the effects of acutely induced hyperglycaemia in non-diabetic subjects as well as hyperglycaemic effects in early diabetes, on mesenteric microcirculation and leucocyte endothelial cell interaction have ...

journal_title：European journal of clinical investigation

authors： Schäffler A,Arndt H,Schölmerich J,Palitzsch K

更新日期：1998-11-01 00:00:00