Abstract:
:Inheritance is a major determinant of increased sodium-lithium countertransport (SLC) activity in hypertension. However, hyperlipidaemia can also cause increased SLC activity in some individuals and it is difficult to distinguish this effect from the effect of hypertension. Erythrocyte SLC activity and its kinetic determinants sodium affinity (km) and maximum velocity (Vmax) were measured in 25 hyperlipidaemic patients and 15 normal controls (NC). Increased SLC activity (0.31 +/- SEM 0.03 mmol Li/(h x 1 cells) vs. NC 0.20 +/- 0.01, P < 0.01) in the hyperlipidaemic patients was associated with increased Vmax (0.59 +/- 0.07 vs. NC 0.41 +/- 0.03, P < 0.01) but normal km (median 120 range [40-324] mmol l-1 vs. 140 [108-260]. Lipid-lowering therapy resulted in decreased SLC activity secondary to a fall in Vmax. Km remained constant despite the changes in lipids and Vmax. The mechanism of increased SLC activity in hyperlipidaemia is different from that in essential hypertension where increased sodium affinity is found. Measurement of the kinetic characteristics of SLC may discriminate between the independent influences of hypertension and hyperlipidaemia on the sodium-lithium countertransporter.
journal_name
Eur J Clin Investjournal_title
European journal of clinical investigationauthors
Rutherford PA,Thomas TH,Laker MF,Wilkinson Rdoi
10.1111/j.1365-2362.1992.tb01435.xkeywords:
subject
Has Abstractpub_date
1992-11-01 00:00:00pages
719-24issue
11eissn
0014-2972issn
1365-2362journal_volume
22pub_type
杂志文章abstract:BACKGROUND:Thyroid hormone has important effects on the cardiovascular system. The consequences of episodes of acute hypothyroidism on cardiac function have been investigated in only a few studies, and their results are inconclusive. Our objective was to investigate the effects of acute hypothyroidism on cardiac functi...
journal_title:European journal of clinical investigation
pub_type: 杂志文章
doi:10.1111/j.1365-2362.2009.02088.x
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abstract::Anaemia is a common condition among pre-end-stage renal disease (pre-ESRD) patients with chronic kidney disease (CKD). Indeed, data from clinical studies indicate that anaemia may be present in as many as two-thirds of such patients. Use of recombinant human erythropoietin (EPO) provides an effective means of correcti...
journal_title:European journal of clinical investigation
pub_type: 杂志文章,评审
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abstract::Beta-thromboglobulin (beta TG), serotonin (5HT) and fibrinopeptide A (FPA) were assessed in twenty-two normal donors before, during, and at the end of leukapheresis. Seven procedures were carried out adding heparin to the circuit, and seven adding acetyl salicylic acid (ASA). The remaining eight procedures were carrie...
journal_title:European journal of clinical investigation
pub_type: 杂志文章
doi:10.1111/j.1365-2362.1985.tb00166.x
更新日期:1985-08-01 00:00:00
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journal_title:European journal of clinical investigation
pub_type: 杂志文章
doi:10.1111/j.1365-2362.1992.tb01939.x
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abstract:BACKGROUND:Patients with chronic kidney disease (CKD) need regular monitoring, usually by blood urea and creatinine measurements, needing venepuncture, frequent attendances and a healthcare professional, with significant inconvenience. Noninvasive monitoring will potentially simplify and improve monitoring. We tested t...
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journal_title:European journal of clinical investigation
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journal_title:European journal of clinical investigation
pub_type: 杂志文章,评审
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更新日期:2009-12-01 00:00:00
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journal_title:European journal of clinical investigation
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journal_title:European journal of clinical investigation
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journal_title:European journal of clinical investigation
pub_type: 杂志文章
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journal_title:European journal of clinical investigation
pub_type: 杂志文章
doi:10.1111/j.1365-2362.1976.tb00532.x
更新日期:1976-09-10 00:00:00
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journal_title:European journal of clinical investigation
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更新日期:2018-06-01 00:00:00
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journal_title:European journal of clinical investigation
pub_type: 杂志文章
doi:10.1111/j.1365-2362.1978.tb00806.x
更新日期:1978-02-01 00:00:00
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journal_title:European journal of clinical investigation
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journal_title:European journal of clinical investigation
pub_type: 杂志文章
doi:10.1111/eci.13272
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journal_title:European journal of clinical investigation
pub_type: 杂志文章
doi:
更新日期:1992-10-01 00:00:00
abstract::We have examined resting and thrombin (0.3 units ml-1) induced release of noradrenaline by washed platelets from 15 normal subjects and eight patients with heterozygous familial hypercholesterolaemia. Platelets from both normal and hypercholesterolaemic subjects showed irreversible aggregation with 0.3 units ml-1 thro...
journal_title:European journal of clinical investigation
pub_type: 杂志文章
doi:10.1111/j.1365-2362.1989.tb00225.x
更新日期:1989-06-01 00:00:00
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journal_title:European journal of clinical investigation
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doi:10.1046/j.1365-2362.1998.00332.x
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journal_title:European journal of clinical investigation
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:European journal of clinical investigation
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doi:10.1111/j.1365-2362.1987.tb01149.x
更新日期:1987-12-01 00:00:00
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journal_title:European journal of clinical investigation
pub_type: 杂志文章
doi:10.1111/j.1365-2362.1978.tb00817.x
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journal_title:European journal of clinical investigation
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1996-08-01 00:00:00
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更新日期:1977-02-01 00:00:00
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journal_title:European journal of clinical investigation
pub_type: 杂志文章
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journal_title:European journal of clinical investigation
pub_type: 杂志文章
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更新日期:1997-12-01 00:00:00
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journal_title:European journal of clinical investigation
pub_type: 杂志文章
doi:10.1046/j.1365-2362.1997.2030750.x
更新日期:1997-11-01 00:00:00
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journal_title:European journal of clinical investigation
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1991-04-01 00:00:00
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journal_title:European journal of clinical investigation
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1996-11-01 00:00:00
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journal_title:European journal of clinical investigation
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