Effects of long-term octreotide treatment on the response of portal-systemic collaterals to vasopressin in portal hypertensive rats.


BACKGROUND:Chronic portal hypertension is associated with the development of portal-systemic collaterals. Long-term octreotide treatment has been shown to enhance the constrictive response to vasopressin in the mesenteric arteries of portal hypertensive rats. This study investigated the effects of long-term octreotide treatment on the response of portal-systemic collaterals to vasopressin in portal hypertensive rats. METHODS:Partially portal vein-ligated rats were divided into two groups to receive subcutaneous injection of either placebo (5% dextrose in water) or octreotide (30 microg kg(-1)) twice daily for 7 days. Two series of experiments were performed to measure: (a) the systemic and portal hemodynamics and cumulative concentration-response curves of collateral vessels to vasopressin (10(-10) to 10(-7 )M) and (b) the slopes of the flow-pressure curves of collaterals (an index of portal-systemic shunting). The cumulative concentration-response curves and flow pressure curves were determined by the in situ collateral perfusion. RESULTS:Long-term octreotide treatment significantly lowered the portal pressure without changes in the mean arterial pressure. Vasopressin significantly and similarly increased the perfusion pressure of collateral vessels in both the placebo- and octreotide-treated groups. In addition, long-term octreotide treatment exerted no effect on the EC(50) of vasopressin (-8.25 +/- 0.19 vs. -8.20 +/- 0.10, P > 0.05) and the slopes of flow-pressure curves (0.97 +/- 0.02 vs. 0.94 +/- 0.04, P > 0.05) in the collaterals. CONCLUSION:Despite lowering the portal pressure, long-term octreotide treatment did not enhance the vasoconstrictive effect of vasopressin in the collateral vessels of portal hypertensive rats and ameliorate the degree of portal-systemic shunting.


Eur J Clin Invest


Wang SS,Chan CC,Lee FY,Chang FY,Lin HC,Chen CT,Huang HC,Tai CC,Lai IN,Lee SD





Has Abstract


2002-05-01 00:00:00














  • Tetrahydroxylated bile acids in healthy human newborns.

    abstract::Urine was collected in four healthy infants, born after 35-39 weeks of gestation. The collections were made for 24 h starting immediately after birth. Bile acids were extracted, separated into conjugate groups, solvolysed, hydrolysed and quantified by gas-liquid chromatography as methyl ester trimethylsilyl ether deri...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章


    authors: Strandvik B,Wikström SA

    更新日期:1982-08-01 00:00:00

  • Response of myocardial cellular energy metabolism to variation of buffer composition during open-chest experimental cardiopulmonary resuscitation in the pig.

    abstract::The aim of the present study was to investigate possible relationships in piglets between myocardial energy-related metabolites and intracellular electrolytes during open-chest cardiopulmonary resuscitation (OCCPR) supplemented by the administration of alkaline buffers with varying sodium content. Our hypothesis was t...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章


    authors: Wiklund L,Ronquist G,Roomans GM,Rubertsson S,Waldenström A

    更新日期:1997-05-01 00:00:00

  • Humming-induced release of nasal nitric oxide for assessment of sinus obstruction in allergic rhinitis: pilot study.

    abstract:BACKGROUND:Humming greatly increases nasal nitric oxide (NO) in healthy people by causing a rapid washout of NO from the sinuses. This increase is abolished in patients with complete sinus ostial obstruction. OBJECTIVE:Allergic rhinitis is a risk factor for development of sinusitis and we wanted to study whether nasal...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章


    authors: Maniscalco M,Sofia M,Weitzberg E,De Laurentiis G,Stanziola A,Rossillo V,Lundberg JO

    更新日期:2004-08-01 00:00:00

  • Heterozygous apolipoprotein C-II deficiency: lipoprotein and apoprotein phenotype and RsaI restriction enzyme polymorphism in the Apo C-IIPadova kindred.

    abstract::Deficiency of apolipoprotein C-II (apo C-II), the cofactor for lipoprotein lipase, results in the familial chylomicronaemia syndrome characterized by severe hypertriglyceridaemia and fasting chylomicronaemia. To investigate the biochemical features of the heterozygous state for apo C-II deficiency, we characterized th...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章


    authors: Gabelli C,Bilato C,Santamarina-Fojo S,Martini S,Brewer HB Jr,Crepaldi G,Baggio G

    更新日期:1993-09-01 00:00:00

  • Associated factors of co-existent pulmonary tuberculosis and lung cancer: A case-control study.

    abstract:BACKGROUND:Although the incidence of co-existent pulmonary tuberculosis (PTB) and lung cancer in China is increasing, risk factors related to its development are still poorly understood. We aimed to investigate which clinical factors were associated with the odds of co-existent PTB and lung cancer (PTB-lung cancer) cas...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章


    authors: Zheng L,Yin J,Wang S,Jiang H,Hu P,Kang Z,Lv P,Li W,Cai C

    更新日期:2020-10-14 00:00:00

  • Effect of heparin and aspirin on platelet and clotting activation during leukapheresis.

    abstract::Beta-thromboglobulin (beta TG), serotonin (5HT) and fibrinopeptide A (FPA) were assessed in twenty-two normal donors before, during, and at the end of leukapheresis. Seven procedures were carried out adding heparin to the circuit, and seven adding acetyl salicylic acid (ASA). The remaining eight procedures were carrie...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章


    authors: Fabris F,Casonato A,Randi ML,Belloni M,Quaino V,Ongaro G,Girolami A

    更新日期:1985-08-01 00:00:00

  • Proposed mechanism of induction of gastric carcinoids: the gastrin hypothesis.

    abstract::Novel, powerful and long-acting inhibitors of gastric acid secretion include second generation H2-blockers and so-called proton pump inhibitors, such as omeprazole. Gastric carcinoids were found to develop in experimental animals as a consequence of continuous long-term administration of several of these highly effect...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章,评审


    authors: Håkanson R,Sundler F

    更新日期:1990-10-01 00:00:00

  • Analysis of hematogones in bone marrow from acute myeloid leukaemia cases posttherapy.

    abstract:BACKGROUND:Increased bone marrow (BM) hematogones (HGs) are often observed in patients with marrow regenerating status. Many studies have focused on the role of HGs in acute lymphoblastic leukaemia (ALL), but very little has been done to understand their effects on acute myeloid leukaemia (AML). MATERIALS AND METHODS:...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章


    authors: Zheng J,Du W,Yao J,You Y,Li W,He Y,Li X,Liu W,Wu Y,Hu Y,Jin R,Zou P,Huang S,Hu Y,Zhang M

    更新日期:2013-11-01 00:00:00

  • Effects of insulin treatment on endoneurial and systemic oxidative stress in relation to nerve conduction in streptozotocin-diabetic rats.

    abstract::As increased oxidative stress is probably a pathogenetic factor in the development of diabetic complications, we studied nerve function and endogenous antioxidants in plasma, erythrocytes and sciatic nerve of untreated and insulin-treated streptozotocin-diabetic rats. After 18 weeks, the diabetes-induced sciatic nerve...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章


    authors: van Dam PS,Bravenboer B,van Asbeck BS,van Oirschot JF,Marx JJ,Gispen WH

    更新日期:1996-12-01 00:00:00

  • Five cardiac hormones decrease the number of human small-cell lung cancer cells.

    abstract:BACKGROUND:Four peptide hormones of a family of six hormones, i.e. atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), C-natriuretic peptide (CNP), long acting natriuretic peptide (LANP), vessel dilator and kaliuretic peptide, significantly decrease the number of adenocarcinoma cells in culture. The pres...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章


    authors: Vesely BA,Song S,Sanchez-Ramos J,Fitz SR,Alli AA,Solivan SM,Gower WR Jr,Vesely DL

    更新日期:2005-06-01 00:00:00

  • Platelet activation and interaction with leucocytes in patients with sepsis or multiple organ failure.

    abstract::This study focuses on the role of platelet membrane glycoproteins and platelet-leucocyte adhesion in patients with sepsis and multiple organ failure (MOF). Specifically, the study raises the following issues: (1) the influence of sepsis and MOF on platelet activation as assessed by surface expression of platelet membr...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章


    authors: Gawaz M,Fateh-Moghadam S,Pilz G,Gurland HJ,Werdan K

    更新日期:1995-11-01 00:00:00

  • Implementation of proteomic biomarkers: making it work.

    abstract::While large numbers of proteomic biomarkers have been described, they are generally not implemented in medical practice. We have investigated the reasons for this shortcoming, focusing on hurdles downstream of biomarker verification, and describe major obstacles and possible solutions to ease valid biomarker implement...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章


    authors: Mischak H,Ioannidis JP,Argiles A,Attwood TK,Bongcam-Rudloff E,Broenstrup M,Charonis A,Chrousos GP,Delles C,Dominiczak A,Dylag T,Ehrich J,Egido J,Findeisen P,Jankowski J,Johnson RW,Julien BA,Lankisch T,Leung HY,Maahs

    更新日期:2012-09-01 00:00:00

  • Amadori-albumin correlates with microvascular complications and precedes nephropathy in type 1 diabetic patients.

    abstract:BACKGROUND:Amadori-albumin, a major glycated protein, is involved in experimental hyperglycaemia-induced microvascular complications, and is associated with advanced nephropathy in Type I diabetic patients in humans. Our aim was to assess the association of Amadori-albumin with early nephropathy and with retinopathy in...

    journal_title:European journal of clinical investigation

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Schalkwijk CG,Chaturvedi N,Twaafhoven H,van Hinsbergh VW,Stehouwer CD,EUCLID Study Group.

    更新日期:2002-07-01 00:00:00

  • Effects of therapeutic percutaneous electrical stimulation of atrophic human quadriceps on muscle composition, protein synthesis and contractile properties.

    abstract::The effects of percutaneous electrical stimulation (70 V, 300 microseconds pulses at 30 Hz) on muscle composition and rate of protein synthesis were studied in seven patients with quadriceps atrophy secondary to unilateral osteoarthritis of the knee (stimulated group). Quadriceps were stimulated on the affected side f...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章


    authors: Gibson JN,Morrison WL,Scrimgeour CM,Smith K,Stoward PJ,Rennie MJ

    更新日期:1989-04-01 00:00:00

  • Fibrinolytic shut-down after surgery: impairment of the balance between tissue-type plasminogen activator and its specific inhibitor.

    abstract::In nine patients with non-malignant diseases undergoing major upper abdominal surgery, the mechanism of the postoperative fibrinolytic shut-down was investigated because of its potential significance for postoperative deep vein thrombosis by employing new and specific methods for assessing and stimulating the fibrinol...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章


    authors: D'Angelo A,Kluft C,Verheijen JH,Rijken DC,Mozzi E,Mannucci PM

    更新日期:1985-12-01 00:00:00

  • Insulin and glucagon secretion by pancreatic islets from nondiabetic and diabetic sand rats (Psammomys obesus).

    abstract::The secretion of insulin and glucagon was investigated in pancreatic islets from diabetic and nondiabetic sand rats of similar age and weight. The metabolic characterization was based on an intraperitoneal glucose tolerance test. Compared to nondiabetic animals diabetic sand rats had a diminished insulin content in th...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章


    authors: Hahn HJ,Schäfer H,Gottschling HD,Fiedler H

    更新日期:1976-01-30 00:00:00

  • Host defence capacities of pulmonary surfactant: evidence for 'non-surfactant' functions of the surfactant system.

    abstract::The most well characterized function of pulmonary surfactant is its ability to reduce surface tension at the alveolar air-liquid interface, thereby preventing lung collapse. However, several lines of evidence suggest that surfactant may also have 'non-surfactant' functions: specific components of surfactant (proteins ...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章,评审


    authors: Pison U,Max M,Neuendank A,Weissbach S,Pietschmann S

    更新日期:1994-09-01 00:00:00

  • Recovery of T-cell subsets after antiretroviral therapy in HIV-infected children.

    abstract:BACKGROUND:Variation of percentageCD4+ T cells may accurately reflects the kinetics of a comprehensive immune recovery independently of the antiretroviral (ART) regimen. To test this we have investigated the relationship among peripheral blood T-cell subsets with the variation of percentageCD4+ T cells during follow up...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章


    authors: Resino S,Bellón JM,Gurbindo D,León JA,Muñoz-Fernández MA

    更新日期:2003-07-01 00:00:00

  • Metabolic abnormalities of apolipoprotein B-containing lipoproteins in non-insulin-dependent diabetes: a stable isotope kinetic study.

    abstract:BACKGROUND:Kinetic abnormalities of apolipoprotein B (apoB)-containing lipoproteins in noninsulin-dependent diabetes mellitus (NIDDM) remain poorly understood. To get further insight into these abnormalities we performed a stable isotope kinetic experiment comparing the metabolism of apoB-containing lipoproteins in mod...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章


    authors: Duvillard L,Pont F,Florentin E,Galland-Jos C,Gambert P,Vergès B

    更新日期:2000-08-01 00:00:00

  • Enterohepatic cycling of bilirubin as a cause of 'black' pigment gallstones in adult life.

    abstract::In contrast to bile salts, which undergo a highly efficient enterohepatic circulation with multiple regulatory and physiologic functions, glucuronic acid conjugates of bilirubin are biliary excretory molecules that in health do not have a continuing biologic life. Intestinal absorptive cells are devoid of recapture tr...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章,评审


    authors: Vítek L,Carey MC

    更新日期:2003-09-01 00:00:00

  • Inhibition of paracrine angiotensin-converting enzyme in vivo: effects on interstitial glucose and lactate concentrations in human skeletal muscle.

    abstract::Microdialysis was used to selectively assess the effect of the paracrine renin-angiotensin system (RAS) on interstitial glucose and lactate concentration profiles in skeletal muscle of healthy volunteers (n = 8) during basal and insulin-stimulated conditions. Paracrine RAS was selectively inhibited by local retrodialy...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章


    authors: Müller M,Fasching P,Schmid R,Burgdorff T,Waldhäusl W,Eichler HG

    更新日期:1997-10-01 00:00:00

  • Effects of myocardial revascularization following acute coronary occlusion in pigs.

    abstract::In a comparative study in pigs the extent of myocardial infarction has been estimated following a temporary three hour coronary occlusion and following a permanent coronary ligation. For evaluation of the cellular injury the infarct size has been determined by a histochemical staining procedure and correlated with ser...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章


    authors: Althaus U,Janett J,Scholl E,Riedwyl H

    更新日期:1976-01-30 00:00:00

  • The effect of smoking on post-heparin lipoprotein and hepatic lipase, cholesteryl ester transfer protein and lecithin:cholesterol acyl transferase activities in human plasma.

    abstract:INTRODUCTION:Smoking is associated with dyslipidaemia, particularly raised plasma triglycerides and reduced high-density lipoprotein (HDL)-cholesterol and a delayed clearance of triglyceride in fat tolerance tests. The aim of this study was to investigate whether these phenomena could be explained by a reduced lipoprot...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章


    authors: Freeman DJ,Caslake MJ,Griffin BA,Hinnie J,Tan CE,Watson TD,Packard CJ,Shepherd J

    更新日期:1998-07-01 00:00:00

  • CREB transcription factor modulates Bcl2 transcription in response to C5a in HL-60-derived neutrophils.

    abstract:BACKGROUND:Complement fragment C5a and neutrophils have been implicated in the pathogenesis of renal disease and C5a has also been shown to delay apoptosis of human neutrophils via a transcription-independent pathway. However, transcription-dependent pathways have not been well described. The present study examined whe...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章


    authors: Perianayagam MC,Madias NE,Pereira BJ,Jaber BL

    更新日期:2006-05-01 00:00:00

  • Effect of dazoxiben, a thromboxane synthetase inhibitor on skin-blood flow following cold challenge in patients with Raynaud's phenomenon.

    abstract::The effects of dazoxiben on finger-blood flow in response to cold challenge were studied in normal subjects and patients with Raynaud's phenomenon. In normal subjects concentrations of TXB2 and 6-oxo-PGF1 alpha were measured in blood taken from dorsal hand veins following cold challenge. In a parallel multicentre stud...

    journal_title:European journal of clinical investigation

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Tindall H,Tooke JE,Menys VC,Martin MF,Davies JA

    更新日期:1985-02-01 00:00:00

  • Lichen planus and hepatitis C virus in the northern Kyushu region of Japan.

    abstract::Oral lichen planus (OLP) is a common oral disorder that manifests a mucosal reaction to a variety of aetiological factors, including liver disorder. This study investigated the relationship between OLP and hepatitis C virus (HCV) infection by studying the prevalence of hepatitis B and C virus infection or liver diseas...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章


    authors: Nagao Y,Sata M,Tanikawa K,Itoh K,Kameyama T

    更新日期:1995-12-01 00:00:00

  • Effect of low protein diet on the renal response to meat ingestion in diabetic nephropathy.

    abstract::We measured the renal haemodynamic and proteinuric response to a meat meal (MM) in ten persistently proteinuric insulin-dependent diabetic patients in a randomized cross-over study of 3 weeks on low protein diet (LPD) or normal protein intake (NPD). On LPD, protein intake (0.64 +/- 0.05 vs 1.15 +/- 0.09 g kg-1 body we...

    journal_title:European journal of clinical investigation

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Pinto JR,Bending JJ,Dodds RA,Viberti GC

    更新日期:1991-04-01 00:00:00

  • Reassignment of the EPB4.1 gene to 1p36 and assessment of its involvement in neuroblastomas.

    abstract:OBJECTIVES:EPB4.1 has been previously mapped to human chromosome 1p33-p34.2. In contradiction to this chromosomal location, we have mapped EPB4.1-1p36 by using fluorescence in situ hybridization and radiation hybrid mapping. In neuroblastomas, deletions of the telomeric end of chromosome 1 (1p36) are the most common ge...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章


    authors: Huang S,Lichtenauer UD,Pack S,Wang C,Kim AC,Lutchman M,Koch CA,Torres-Cruz J,Huang SC,Benz EJ Jr,Christiansen H,Dockhorn-Dworniczak B,Poremba C,Vortmeyer AO,Chishti AH,Zhuang Z

    更新日期:2001-10-01 00:00:00

  • Physicochemical and functional modifications induced by obesity on human erythrocyte membranes.

    abstract:BACKGROUND:Na+,K(+)-ATPase activity was evaluated in relation to membrane composition and molecular organization in erythrocyte membranes from obese patients by the amphyphylic molecule 6-dodecanoyl-2-dimethylamino-naphthalene (Laurdan). Its possible relationship with fat distribution and hyperinsulinaemia was also inv...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章


    authors: Faloia E,Garrapa GG,Martarelli D,Camilloni MA,Lucarelli G,Staffolani R,Mantero F,Curatola G,Mazzanti L

    更新日期:1999-05-01 00:00:00

  • Human and porcine smooth muscle cells share similar proliferation dependence on the mevalonate pathway: implication for in vivo interventions in the porcine model.

    abstract::Proliferation of smooth muscle cells (SMCs) plays an important role in vascular pathobiology by being involved in the development of coronary atherosclerosis and restenosis. Competitive inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase have shown antiproliferative properties on different cell typ...

    journal_title:European journal of clinical investigation

    pub_type: 杂志文章


    authors: Martínez-González J,Badimon L

    更新日期:1996-11-01 00:00:00