当前位置： SCI文献检索 > EUROPEAN JOURNAL OF CLINICAL INVESTIGATION期刊下所有文献 > Ascorbate-induced hyperoxalaemia has no significant effect on lactate generation or erythrocyte 2,3,diphosphoglycerate in dialysis patients.

Ascorbate-induced hyperoxalaemia has no significant effect on lactate generation or erythrocyte 2,3,diphosphoglycerate in dialysis patients.

Abstract：

:To examine the possible effects of hyperoxalaemia on anaerobic metabolism and erythrocyte pyruvate kinase activity, we induced a rise in plasma oxalate in 11 dialysis patients by the oral administration of ascorbic acid, 500 mg day-1 for 3 weeks. Blood samples were taken from the same antecubital vein before and after the supplementation period, without venous stasis, after an overnight fast. This protocol allowed patients to be used as their own controls. Five healthy subjects underwent an identical protocol to exclude any effect of ascorbate per se. Mean (SEM) plasma oxalate (mumol l-1) rose from 30.3 (3.5) to 48.4 (6.1) in patients and from 1.4 (0.2) to 6.8 (0.9) in healthy subjects. Whole blood ascorbate (mg l-1) rose from 7.0 (0.7) to 26.6 (2.5) in patients and from 9.3 (1.2) to 17.8 (1.8) in healthy subjects (reference range 7.5-20.0 mg l-1). No changes were observed in either group in plasma creatinine, bicarbonate, haemoglobin, or erythrocyte 2,3,diphosphoglycerate (2,3 DPG) after the 3 week supplementation period. Before supplementation lactate generation (area under curve, mmol min l-1) in the 5 min following a 60 s period of standardized ischaemic forearm exercise was significantly (P = 0.026) greater in patients [69.1 (4.7)] than in healthy subjects [46.9 (6.7)]; no significant change in lactate generation occurred in either group after ascorbate-induced hyperoxalaemia. We conclude that changes in plasma oxalate of the order of 20 mumol l-1 have no significant effect on lactate generation or 2,3,DPG levels in uraemic subjects.

journal_name

Eur J Clin Invest

journal_title

European journal of clinical investigation

authors

Tomson CR,Channon SM,Ward MK,Laker MF

doi

10.1111/j.1365-2362.1990.tb01878.x

subject

Has Abstract

pub_date

1990-08-01 00:00:00

pages

411-5

issue

4

eissn

0014-2972

issn

1365-2362

journal_volume

20

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION文献大全
  • Complete iodide trapping defect in two cases with congenital hypothyroidism: adaptation of thyroid to huge iodide supplementation.

    abstract：:Two cases of congenital defect in iodide trapping mechanism are related. The absence of thyroid and gastric concentration of 99mTcO4 led to the diagnosis. The study of saliva and gastric:serum concentration ratios confirmed the complete defect. The kinetics of radioiodine studied by external detection showed an early ...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.1987.tb01244.x

    authors： Leger FA,Doumith R,Courpotin C,Helal OB,Davous N,Aurengo A,Savoie JC

    更新日期：1987-06-01 00:00:00

  • Factors influencing spontaneous mobilization of CD34+ and CD133+ progenitor cells after myocardial infarction.

    abstract：BACKGROUND:Bone marrow-derived circulating progenitor cells (BM-CPCs) are mobilized into adult peripheral blood (PB) during acute myocardial infarction (AMI) and may contribute to the regeneration of infarcted myocardium. The purpose of the present study is to determine whether mobilization of BM-CPCs into PB depends o...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.2007.01876.x

    authors： Turan RG,Brehm M,Koestering M,Tobias Z,Bartsch T,Steiner S,Picard F,Ebner P,Schannwell CM,Strauer BE

    更新日期：2007-11-01 00:00:00

  • The association between CYBA gene C242T variant and risk of metabolic syndrome.

    abstract：BACKGROUND:Both inflammation and oxidative stress may contribute to pathogenesis of metabolic syndrome (MetS). The C242T polymorphism (rs4673) in the CYBA gene, as the main components of NAD (P) H oxidase, causes inter-individual variability in the enzyme activity. We aimed to investigate the association between this p...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/eci.13275

    authors： Pourgholi L,Pourgholi F,Ziaee S,Goodarzynejad H,Hosseindokht M,Boroumand M,Mandegary A

    更新日期：2020-09-01 00:00:00

  • Platelet noradrenaline release in patients with familial hypercholesterolaemia.

    abstract：:We have examined resting and thrombin (0.3 units ml-1) induced release of noradrenaline by washed platelets from 15 normal subjects and eight patients with heterozygous familial hypercholesterolaemia. Platelets from both normal and hypercholesterolaemic subjects showed irreversible aggregation with 0.3 units ml-1 thro...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.1989.tb00225.x

    authors： Smith CC,Wilson AP,Prichard BN,Betteridge DJ

    更新日期：1989-06-01 00:00:00

  • C5a anaphylatoxin and its role in critical illness-induced organ dysfunction.

    abstract：:Critical illness is an aetiologically and clinically heterogeneous syndrome that is characterised by organ failure and immune dysfunction. Mortality in critically ill patients is driven by inflammation-associated organ damage and a profound vulnerability to nosocomial infection. Both factors are influenced by the acti...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章,评审

    doi：10.1111/eci.13028

    authors： Wood AJT,Vassallo A,Summers C,Chilvers ER,Conway-Morris A

    更新日期：2018-12-01 00:00:00

  • Accuracy of prehospital point-of-care lactate in early in-hospital mortality.

    abstract：BACKGROUND:Emergency medical services (EMS) routinely face complex scenarios where decisions should be taken with limited clinical information. The development of fast, reliable and easy to perform warning biomarkers could help in such decision-making processes. The present study aims at characterizing the validity of ...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/eci.13341

    authors： Martín-Rodríguez F,López-Izquierdo R,Medina-Lozano E,Ortega Rabbione G,Del Pozo Vegas C,Carbajosa Rodríguez V,Castro Villamor MÁ,Sánchez-Soberon I,Sanz-García A

    更新日期：2020-12-01 00:00:00

  • Nonalcoholic fatty liver disease increases the risk of gastroesophageal reflux disease: A systematic review and meta-analysis.

    abstract：BACKGROUND:Increasing evidence indicates that nonalcoholic fatty liver disease (NAFLD) is linked to an increased risk of extra-hepatic conditions. However, it is currently uncertain whether NAFLD is associated with the risk of gastroesophageal reflux disease (GERD). We performed a systematic review and meta-analysis of...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章,meta分析

    doi：10.1111/eci.13158

    authors： Xue J,Xin H,Ren N,Zhou C,Yang J,Song L,Qin S

    更新日期：2019-09-01 00:00:00

  • Quinidine reduces biliary clearance of digoxin in man.

    abstract：:Quinidine is known to reduce the renal clearance of digoxin, but this effect does not completely explain the influence of quinidine on the total clearance of digoxin. We therefore studied the effect of quinidine administration on biliary clearance of digoxin in five patients with atrial fibrillation. Biliary clearance...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.1987.tb01246.x

    authors： Angelin B,Arvidsson A,Dahlqvist R,Hedman A,Schenck-Gustafsson K

    更新日期：1987-06-01 00:00:00

  • Irradiated cultured apoptotic peripheral blood mononuclear cells regenerate infarcted myocardium.

    abstract：BACKGROUND:Acute myocardial infarction (AMI) is followed by post AMI cardiac remodelling, often leading to congestive heart failure. Homing of c-kit+ endothelial progenitor cells (EPC) has been thought to be the optimal source for regenerating infarcted myocardium. METHODS:Immune function of viable peripheral blood mo...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.2009.02111.x

    authors： Ankersmit HJ,Hoetzenecker K,Dietl W,Soleiman A,Horvat R,Wolfsberger M,Gerner C,Hacker S,Mildner M,Moser B,Lichtenauer M,Podesser BK

    更新日期：2009-06-01 00:00:00

  • Plasma lipids affect maximum velocity not sodium affinity of human sodium-lithium countertransport: distinction from essential hypertension.

    abstract：:Inheritance is a major determinant of increased sodium-lithium countertransport (SLC) activity in hypertension. However, hyperlipidaemia can also cause increased SLC activity in some individuals and it is difficult to distinguish this effect from the effect of hypertension. Erythrocyte SLC activity and its kinetic det...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.1992.tb01435.x

    authors： Rutherford PA,Thomas TH,Laker MF,Wilkinson R

    更新日期：1992-11-01 00:00:00

  • HIF-1α and HIF-2α induce angiogenesis and improve muscle energy recovery.

    abstract：BACKGROUND:Cardiovascular patients suffer from reduced blood flow leading to ischaemia and impaired tissue metabolism. Unfortunately, an increasing group of elderly patients cannot be treated with current revascularization methods. Thus, new treatment strategies are urgently needed. Hypoxia-inducible factors (HIFs) upr...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/eci.12333

    authors： Niemi H,Honkonen K,Korpisalo P,Huusko J,Kansanen E,Merentie M,Rissanen TT,André H,Pereira T,Poellinger L,Alitalo K,Ylä-Herttuala S

    更新日期：2014-10-01 00:00:00

  • TGF-beta1 overexpression in the transversalis fascia of patients with direct inguinal hernia.

    abstract：BACKGROUND:The aetiology of inguinal hernia includes changes in collagen turnover and metalloproteinase (MMP) expression, and direct hernia has been linked to increased MMP-2 expression. Since transforming growth factor beta1 (TGFbeta1) plays a role in tissue remodelling, this growth factor could directly affect metall...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.2007.01816.x

    authors： Pascual G,Corrales C,Gómez-Gil V,Buján J,Bellón JM

    更新日期：2007-06-01 00:00:00

  • Ischaemia or reperfusion: which is a main trigger for changes in nitric oxide mRNA synthases expression?

    abstract：OBJECTIVE:To investigate alterations in endothelial nitric oxide synthase and inducible nitric oxide synthase mRNA expressions and nitric oxide release in the myocardium during ischaemia/reperfusion and determine whether these changes are ischaemic and/or reperfusion dependent. MATERIALS AND METHODS:Isolated rat heart...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.2005.01553.x

    authors： Pevni D,Frolkis I,Shapira I,Schwartz D,Schwartz IF,Chernichovski T,Lev-Ran O,Sharony R,Uretzky G

    更新日期：2005-09-01 00:00:00

  • Bone mass and biochemical parameters of bone metabolism in men with spinal osteoporosis.

    abstract：:With advancing age both sexes have an increased incidence of osteoporotic fractures, although fractures are more common in women than in men. Whereas in women several potential risk factors have been identified, less is known about osteoporosis in men. A total of 27 Austrian men (mean age: 65 +/- 2 years) with atrauma...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.1992.tb01503.x

    authors： Resch H,Pietschmann P,Woloszczuk W,Krexner E,Bernecker P,Willvonseder R

    更新日期：1992-08-01 00:00:00

  • PPARgamma2 protects against obesity by means of a mechanism that mediates insulin resistance.

    abstract：BACKGROUND:Many studies have focused on the physiological parameters and genetic predisposition of subjects presenting both obesity and insulin resistance (IR) and it has been suggested that the peroxisome proliferator-activated receptor gamma 2 (PPARgamma2) Pro12Ala variant may contribute to the observed variability i...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.2009.02198.x

    authors： Macias-Gonzalez M,Moreno-Santos I,García-Almeida JM,Tinahones FJ,Garcia-Fuentes E

    更新日期：2009-11-01 00:00:00

  • Determinants of the postpericardiotomy syndrome: a systematic review.

    abstract：BACKGROUND:Postpericardiotomy syndrome (PPS) is a common complication following cardiac surgery; however, the exact pathogenesis remains uncertain. Identifying risk factors of PPS might help to better understand the syndrome. The aim of this study was to provide an overview of existing literature around determinants of...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章,评审

    doi：10.1111/eci.12764

    authors： van Osch D,Nathoe HM,Jacob KA,Doevendans PA,van Dijk D,Suyker WJ,Dieleman JM

    更新日期：2017-06-01 00:00:00

  • Why is soluble intercellular adhesion molecule-1 related to cardiovascular mortality?

    abstract：:Increased plasma levels of soluble adhesion molecules are associated with an increased risk of atherothrombosis. The pathophysiological mechanisms responsible for these associations are not known. The aim of the present study was to investigate the association of soluble intercellular adhesion molecule-1 (sICAM-1) con...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1046/j.1365-2362.2002.00919.x

    authors： Becker A,van Hinsbergh VW,Jager A,Kostense PJ,Dekker JM,Nijpels G,Heine RJ,Bouter LM,Stehouwer CD

    更新日期：2002-01-01 00:00:00

  • The normal occurrence of two molecular forms of the eight complement component (C8) and their concentrations in a family with C8 deficiency.

    abstract：:A haemolytically inactive alpha-mobile complement C8 component was identified by crossed immunoelectrophoresis in a 27-year-old male with recurrent meningococcal infections and absence of complement mediated serum haemolytic activity. The patient's serum/plasma contained no demonstrable normal C8. C8 inhibitor activit...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.1983.tb00084.x

    authors： Brandslund I,Teisner B,Strate M,Grunnet N,Svehag SE,Isager H,Wang P

    更新日期：1983-04-01 00:00:00

  • Effect of hormone replacement therapy on the susceptibility of low-density lipoprotein to oxidation among postmenopausal hypercholesterolaemic women.

    abstract：:The effect of sequential combined hormone replacement therapy on the susceptibility of low-density lipoprotein to oxidative modification was investigated in a double-blind, randomized placebo-controlled study. Hypercholesterolaemic, postmenopausal women were supplemented with 17 beta-oestradiol and norethisterone acet...

    journal_title：European journal of clinical investigation

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1046/j.1365-2362.1996.390593.x

    authors： Nenseter MS,Volden V,Berg T,Drevon CA,Ose L,Tonstad S

    更新日期：1996-12-01 00:00:00

  • Plasma renin activity in diabetic autonomic neuropathy.

    abstract：:Postural changes in plasma renin activity were studied in three groups of age and duration-matched male diabetics (potent, impotent and with postural hypotension) and in non-diabetic control subjects. Those diabetic subjects with postural hypotension due to automatic neuropathy had no increase in plasma renin activity...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.1976.tb00532.x

    authors： Campbell IW,Ewing DJ,Anderton JL,Thompson JH,Horn DB,Clarke BF

    更新日期：1976-09-10 00:00:00

  • Prognostic value of serum lactic dehydrogenase (S-LDH) in multiple myeloma.

    abstract：:Serum lactic dehydrogenase (S-LDH) was analysed at diagnosis in ninety-three patients with multiple myeloma. The patients were then followed up after a mean observation period of 39 months (SD 29). Serum lactic dehydrogenase was elevated in twenty-seven out of ninety-three patients and found to correlate with the seru...

    journal_title：European journal of clinical investigation

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1111/j.1365-2362.1987.tb02197.x

    authors： Simonsson B,Brenning G,Källander C,Ahre A

    更新日期：1987-08-01 00:00:00

  • Markers of inflammation and disuse in vastus lateralis of chronic obstructive pulmonary disease patients.

    abstract：BACKGROUND:Disuse and/or local inflammation in the muscle cannot be excluded as potential influences for the decreased muscle force in patients hospitalised due to an acute chronic obstructive pulmonary disease (COPD) exacerbation. This study aims to compare expression levels of markers of disuse (insulin-like growth f...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.2007.01867.x

    authors： Crul T,Spruit MA,Gayan-Ramirez G,Quarck R,Gosselink R,Troosters T,Pitta F,Decramer M

    更新日期：2007-11-01 00:00:00

  • Effect of insulin analogues on 3t3-l1 adipogenesis and lipolysis.

    abstract：BACKGROUND:Insulin has several biological functions besides glycaemic control. We investigated and compared the effects of six different commercial insulins on adipocyte cell differentiation, the lipolytic activity of differentiated cells, and the expression levels of genes involved in adipogenesis and associated with ...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.2011.02492.x

    authors： García-Escobar E,Rodríguez-Pacheco F,Haro-Mora JJ,Gomez-Zumaquero JM,Rubio-Martín E,Gutierrez-Repiso C,Soriguer F,Rojo-Martínez G

    更新日期：2011-09-01 00:00:00

  • Association of high plasma antioxidant capacity with new lesion formation in carotid atherosclerosis: a prospective study.

    abstract：BACKGROUND:In atherosclerosis, both reductions and elevations in plasma levels of antioxidants have been reported. This study investigated total antioxidant capacity of plasma from subjects with atherosclerotic disease. MATERIALS AND METHODS:The study population consisted of 48 men with or without carotid atherosclero...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1046/j.1365-2362.1998.00357.x

    authors： Reinisch N,Kiechl S,Mayr C,Schratzberger P,Dunzendorfer S,Kähler CM,Buratti T,Willeit J,Wiedermann CJ

    更新日期：1998-10-01 00:00:00

  • Lack of association between changes in plasma leptin concentration and in food intake during the menstrual cycle.

    abstract：BACKGROUND:Changes in plasma leptin concentration and food intake occur during the menstrual cycle; because leptin regulates food intake, one could hypothesize that changes in plasma leptin concentration and in food intake are associated throughout the menstrual cycle. However, no data have ever been provided to suppor...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1046/j.1365-2362.1999.00488.x

    authors： Paolisso G,Rizzo MR,Mazziotti G,Rotondi M,Tagliamonte MR,Varricchio G,Carella C,Varricchio M

    更新日期：1999-06-01 00:00:00

  • Anabolic effects of rhIGF-I/IGFBP-3 in vivo are influenced by thyroid status.

    abstract：BACKGROUND:There are close interrelationships between hormones that regulate bone formation and protein biosynthesis. For example, growth hormone and thyroid hormones can influence plasma levels of insulin-like growth factor-I (IGF-I). A patient's status regarding hormones other than IGF-I may thus indirectly modify th...

    journal_title：European journal of clinical investigation

    pub_type： 临床试验,杂志文章

    doi：10.1046/j.1365-2362.2001.00793.x

    authors： Svanberg E,Healey J,Mascarenhas D

    更新日期：2001-04-01 00:00:00

  • Sympathetic activation in cardiovascular disease: evidence, clinical impact and therapeutic implications.

    abstract：BACKGROUND:The sympathetic nervous exerts a key role in cardiovascular homeostasis control by regulating cardiac output, systemic vascular resistance, heart rate and blood pressure. MATERIALS AND METHODS:Data collected during the past 30 years have unequivocally shown that in a considerable number of cardiovascular as...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章,评审

    doi：10.1111/eci.12553

    authors： Grassi G,Seravalle G,Mancia G

    更新日期：2015-12-01 00:00:00

  • Increase in type I and type IV collagenolytic activity in primary cultures of keratoconus cornea.

    abstract：:The collagenolytic activities were assayed in fibroblast cultures established from ten keratoconus and six control corneal explants. The assays included those for both type I and type IV collagenase. The amount of free, directly assayable type I collagenase was highly increased in the media of keratoconus primary cell...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.1986.tb01311.x

    authors： Ihalainen A,Salo T,Forsius H,Peltonen L

    更新日期：1986-02-01 00:00:00

  • Bacteria and spontaneous experimental colitis: immunological changes.

    abstract：BACKGROUND:Intestinal commensal flora seems to be a requisite for both human and experimental intestinal inflammation. Our aim was to assess the immunological changes in the colon of IL-10(-/-) mice depending on the environmental conditions. MATERIALS AND METHODS:Twelve wild-type (WT) and 24 IL-10(-/-) 4-week-old mice...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.2011.02499.x

    authors： Pedrosa E,Lorén V,Cabré E,Doménech E,Ojanguren I,Gassull MA,Mañé J

    更新日期：2011-10-01 00:00:00

  • A comparative study of two methods of measurement of fractional calcium absorption: results in normal individuals and patients with various disturbances of calcium metabolism.

    abstract：:Two methods of measurement of fractional calcium absorption have been compared in the same individuals. There is a significant correlation between fractional 47Ca absorption as measured with a blood counting method and with an external counting method after intravenous and oral administration of 47Ca (P less than 0.00...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.1978.tb00826.x

    authors： Juttmann JR,Ruis AM,Hagenouw-Taal JC,Lockefeer JH,Birkenhäger JC

    更新日期：1978-06-01 00:00:00