当前位置： SCI文献检索 > EUROPEAN JOURNAL OF CLINICAL INVESTIGATION期刊下所有文献 > TGF-beta1 overexpression in the transversalis fascia of patients with direct inguinal hernia.

TGF-beta1 overexpression in the transversalis fascia of patients with direct inguinal hernia.

Abstract：

BACKGROUND:The aetiology of inguinal hernia includes changes in collagen turnover and metalloproteinase (MMP) expression, and direct hernia has been linked to increased MMP-2 expression. Since transforming growth factor beta1 (TGFbeta1) plays a role in tissue remodelling, this growth factor could directly affect metalloproteinase secretion and thus the proteolytic activity of these enzymes. We hypothesized that TGFbeta1 expression could also be altered in direct inguinal hernias. MATERIALS AND METHODS:Tissue specimens were obtained from the transversalis fascia (TF) of organ donors (controls; n = 10) and patients with inguinal hernia (indirect; n = 20/direct; n = 20), who were also divided into two groups according to age (20-40/41-60 years). Tissue sections were immunohistochemically labelled using anti-LAP TGFbeta1 (latent form) and anti-TGFbeta1 (active form) antibodies, and fragments of tissue were subjected to Western blot analysis. RESULTS:No significant differences in LAP-TGFbeta1 expression were detected between specimens from control and hernia patients. However, significantly higher levels of active TGFbeta1 were detected in the TF of patients with direct hernia (P < 0.05). Age affected the expression of the growth factor in its active form, and significant differences emerged between direct hernias and controls/indirect hernias only in the younger age groups. CONCLUSIONS:Our findings indicate overexpression of the active form of TGFbeta1 in the TF of young patients with direct hernia. This overexpression reflects an attempt to counterbalance the enhanced matrix degradation process observed in these patients, identifying a subset of patients requiring the use of a prosthetic material for primary hernia repair.

journal_name

Eur J Clin Invest

journal_title

European journal of clinical investigation

authors

Pascual G,Corrales C,Gómez-Gil V,Buján J,Bellón JM

doi

10.1111/j.1365-2362.2007.01816.x

subject

Has Abstract

pub_date

2007-06-01 00:00:00

pages

516-21

issue

6

eissn

0014-2972

issn

1365-2362

pii

ECI1816

journal_volume

37

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION文献大全
  • Urinary excretion of complement C3d in patients with renal diseases.

    abstract：INTRODUCTION:Complement-mediated tubular injury may play an important role in the progression of renal diseases. C3d is a presumed marker of complement activation. Its precursor C3dg has been detected in the urine of patients with membranous nephropathy. However, little is known of the renal handling of C3d or its excr...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1046/j.1365-2362.2003.01153.x

    authors： Branten AJ,Kock-Jansen M,Klasen IS,Wetzels JF

    更新日期：2003-06-01 00:00:00

  • Relative down-regulation of apoptosis and autophagy genes in colorectal cancer.

    abstract：BACKGROUND:Cancer is often caused by disturbance in the regulation and/or execution of programmed cell death (PCD, including apoptosis and autophagy). Our aim was to investigate these two pathways simultaneously in the same samples to understand further the pathological roles of PCDs in colorectal cancer. MATERIALS AN...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.2010.02383.x

    authors： Chang YT,Tseng HC,Huang CC,Chen YP,Chiang HC,Chou FP

    更新日期：2011-01-01 00:00:00

  • Reduced circulating levels of TWEAK are associated with gestational diabetes mellitus.

    abstract：BACKGROUND:To evaluate the inflammatory axis mediated by tumour necrosis factor-like weak inducer of apoptosis (TWEAK) and its scavenger receptor CD163 during pregnancy and their influence on insulin sensitivity in normal pregnancy and in gestational diabetes mellitus (GDM). MATERIALS AND METHODS:One hundred and thirt...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/eci.12375

    authors： Simón-Muela I,Llauradó G,Chacón MR,Olona M,Näf S,Maymó-Masip E,Gil P,de la Flor M,Gonzalez Clemente JM,Vendrell J,Megía A

    更新日期：2015-01-01 00:00:00

  • Why is soluble intercellular adhesion molecule-1 related to cardiovascular mortality?

    abstract：:Increased plasma levels of soluble adhesion molecules are associated with an increased risk of atherothrombosis. The pathophysiological mechanisms responsible for these associations are not known. The aim of the present study was to investigate the association of soluble intercellular adhesion molecule-1 (sICAM-1) con...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1046/j.1365-2362.2002.00919.x

    authors： Becker A,van Hinsbergh VW,Jager A,Kostense PJ,Dekker JM,Nijpels G,Heine RJ,Bouter LM,Stehouwer CD

    更新日期：2002-01-01 00:00:00

  • The glomerular sieving of pepsinogen A and C in man.

    abstract：:Pepsinogen A (PGA) and pepsinogen C (PGC) are negatively charged, low molecular weight (LMW) proteins with a striking difference in renal handling: PGA (molecular weight 43,500 daltons) shows a high fractional excretion while the fractional excretion of PGC (molecular weight 40,500 daltons) is low, presumably due to t...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.1989.tb00234.x

    authors： ten Kate RW,Pals G,Res JC,van Kamp GJ,Verheugt FW,Pronk JC,Donker AJ,Eriksson AW,Meuwissen SG

    更新日期：1989-06-01 00:00:00

  • Broad identification of bacterial type from pus by 1H MR spectroscopy.

    abstract：BACKGROUND:Abscess formation is a common bacterial infection and requires an immediate antimicrobial approach for apposite treatment. Delay in patient treatment is usually a common feature, as the bacterial identification of clinical samples is based on the culture, which is a time-consuming exercise. The current study...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1046/j.1365-2362.2003.01148.x

    authors： Garg M,Misra MK,Chawla S,Prasad KN,Roy R,Gupta RK

    更新日期：2003-06-01 00:00:00

  • Lipid parameters in patients with acute coronary syndromes versus stable coronary artery disease.

    abstract：BACKGROUND:Differences in lipid parameters between patients with acute coronary syndromes (ACS) and patients with stable coronary artery disease (CAD) are unclear and are addressed in this study. METHODS:We enrolled 582 patients with angiographically proven stable CAD (of whom 26·9% had diabetes mellitus type 2 (T2DM)...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/eci.12513

    authors： Vonbank A,Saely CH,Rein P,Drexel H

    更新日期：2015-10-01 00:00:00

  • Antisense c-myc fragments induce normal differentiation cycles in HL-60 cells.

    abstract：BACKGROUND:We have investigated the potential for using antisense technology as a means of delivering treatment for acute myeloblastic leukaemia (FAB-M2) by gene therapy. MATERIALS AND METHODS:A test recombinant adenovirus vector was constructed containing human c-myc antisense fragments to study the effects of alteri...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.2006.01589.x

    authors： Chen JP,Chen L,Leek J,Lin C

    更新日期：2006-01-01 00:00:00

  • Effect of acute hyperglycaemia on sensory processing in diabetic autonomic neuropathy.

    abstract：BACKGROUND:Acute hyperglycaemia is known to increase gastrointestinal (GI) sensitivity in healthy subjects and may contribute to the increased prevalence of GI symptoms in diabetes patients. The aim of this study was to evaluate the effect of acute hyperglycaemia on perception and brain responses to painful visceral an...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.2010.02335.x

    authors： Frøkjaer JB,Søfteland E,Graversen C,Dimcevski G,Drewes AM

    更新日期：2010-10-01 00:00:00

  • Multiple biochemical effects in the pathogenesis of alcoholic fatty liver.

    abstract：:The pathogenesis of alcoholic fatty liver is unknown, but several causes have been proposed based on biochemical findings. These include the metabolism of alcohol leading to a shift in the cytosolic [NAD+]/ [NADH] ratio to reduction, which in turn causes a direct inhibition of beta-oxidation and enhanced triacylglycer...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章,评审

    doi：10.1046/j.1365-2362.1997.1780727.x

    authors： Eaton S,Record CO,Bartlett K

    更新日期：1997-09-01 00:00:00

  • Hyperaluminaemia in critically ill patients: role of antacid therapy and impaired renal function.

    abstract：:A significant rise in serum concentrations of aluminum was demonstrated in 23 patients prophylactically treated with the antacid magaldrate, whereas no increase in serum aluminium was observed in another 26 critically ill patients, in whom the use of antacids was avoided. In parallel, urinary excretion rates of alumin...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.1991.tb01365.x

    authors： Ittel TH,Gladziwa U,Mück W,Sieberth HG

    更新日期：1991-02-01 00:00:00

  • Effects of insulin-like growth factor-I (IGF-I), insulin and combined IGF-I-insulin infusions on protein metabolism in dogs.

    abstract：:The effect of infusions of recombinant insulin-like growth factor-I (IGF-I) (34, 103 or 688 pmol min-1 kg-1), insulin (3.4, 10.3 or 68.8 pmol min-1 kg-1) or combined infusions (34 pmol IGF-I + 3.4 pmol min-1 kg-1 insulin or 103 pmol IGF-I + 3.4 pmol min-1 kg-1 insulin) on protein metabolism, using an infusion of [1-14...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.1994.tb01094.x

    authors： Umpleby AM,Shojaee-Moradie F,Thomason MJ,Kelly JM,Skottner A,Sonksen PH,Jones RH

    更新日期：1994-05-01 00:00:00

  • Pregnancy-associated plasma protein A and mortality in haemodialysis.

    abstract：BACKGROUND:Elevated pregnancy-associated plasma protein A (PAPP-A) levels are associated with increased risk of death in ischaemic heart disease as well as in haemodialysis patients. Previous research indicates that the prognostic value of PAPP-A may be stronger in patients with concomitant diabetes mellitus or signs o...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章,多中心研究

    doi：10.1111/eci.12959

    authors： Nilsson E,Rudholm T,Stenvinkel P,Ärnlöv J

    更新日期：2018-08-01 00:00:00

  • Effect of food on antacid neutralizing capacity in man.

    abstract：:In order to estimate their in-vivo reactivity two antacids of equal theoretical neutralizing capacity (approximately 3.9 mol/l at pH 3.5) but of different chemical composition were employed as intragastric titrant (pH 3.5) following a liquid protein meal (oxo) in two groups of five volunteers each. The two antacids ch...

    journal_title：European journal of clinical investigation

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1111/j.1365-2362.1982.tb00995.x

    authors： Halter F,Huber R,Häcki WH,Varga L,Bachmann C

    更新日期：1982-06-01 00:00:00

  • Associated factors of co-existent pulmonary tuberculosis and lung cancer: A case-control study.

    abstract：BACKGROUND:Although the incidence of co-existent pulmonary tuberculosis (PTB) and lung cancer in China is increasing, risk factors related to its development are still poorly understood. We aimed to investigate which clinical factors were associated with the odds of co-existent PTB and lung cancer (PTB-lung cancer) cas...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/eci.13432

    authors： Zheng L,Yin J,Wang S,Jiang H,Hu P,Kang Z,Lv P,Li W,Cai C

    更新日期：2020-10-14 00:00:00

  • Influence of apolipoprotein E polymorphism on plasma vitamin A and vitamin E levels.

    abstract：BACKGROUND:Plasma concentrations of vitamins A and E are positively correlated with those of concurrent lipids and, on the other hand, lipid levels are influenced by apolipoprotein E polymorphism. Therefore, the effect of this polymorphism on both vitamins was analysed in an adult population. MATERIALS AND METHODS:Sub...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1046/j.1365-2362.2002.00983.x

    authors： Gómez-Coronado D,Entrala A,Alvarez JJ,Ortega H,Olmos JM,Castro M,Sastre A,Herrera E,Lasunción MA

    更新日期：2002-04-01 00:00:00

  • Captopril enhances insulin responsiveness of forearm muscle tissue in non-insulin-dependent diabetes mellitus.

    abstract：:Bradykinin infusion has been shown to improve glucose metabolism in non-insulin-dependent diabetic subjects (NIDD). Therefore, we tested the following hypothesis: inhibition of Kininase II, the bradykinin (BK) degrading enzyme, by captopril may also improve glucose metabolism in NIDD. Immediate effects of captopril on...

    journal_title：European journal of clinical investigation

    pub_type： 临床试验,杂志文章

    doi：10.1111/j.1365-2362.1987.tb01141.x

    authors： Jauch KW,Hartl W,Guenther B,Wicklmayr M,Rett K,Dietze G

    更新日期：1987-10-01 00:00:00

  • High-dose glucose-insulin-potassium treatment reduces myocardial apoptosis in patients with acute myocardial infarction.

    abstract：BACKGROUND:Several clinical trials have suggested that a metabolic cocktail of glucose-insulin-potassium (GIK) decreases mortality rates in patients with acute myocardial infarction (AMI). It has also been reported that Fas-mediated apoptosis plays an important role in ischaemic/reperfusion injury in the rat model. Thi...

    journal_title：European journal of clinical investigation

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1111/j.1365-2362.2005.01468.x

    authors： Zhang L,Zhang L,Li YH,Zhang HY,Chen ML,Gao MM,Hu AH,Yang HS,Yang HS

    更新日期：2005-03-01 00:00:00

  • The role of intravenous administration of dextran 70 in enteric bacterial translocation after partial hepatectomy in rats.

    abstract：:The aim of this study was to assess the effect of intravenous dextran on bacterial translocation and intestinal vascular endothelial and epithelial barrier function after experimental partial hepatectomy. We determined systemic arterial pressure, enteric bacterial growth (proximal and distal small intestine and colon)...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1046/j.1365-2362.1997.2030750.x

    authors： Wang XO,Sun ZW,Soltesz V,Deng XM,Andersson R

    更新日期：1997-11-01 00:00:00

  • Effect of indomethacin upon angiotensin-induced changes in blood pressure and plasma aldosterone in normal man.

    abstract：:The effect of indomethacin (75 mg/day for 3 days) on the response to i.v. angiotensin II was investigated in eight healthy, sodium-repleted, male subjects. Indomethacin reduced the release of aldosterone during the i.v. administration of angiotensin II (5, 10 and 20 ng kg-1 min-1), whereas the pressor response to angi...

    journal_title：European journal of clinical investigation

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1111/j.1365-2362.1981.tb02044.x

    authors： Vierhapper H,Waldhäusl W,Nowotny P

    更新日期：1981-04-01 00:00:00

  • Studies on the turnover of endogenous cathodal trypsinogen in man.

    abstract：:The concentration in serum of cathodal trypsinogen has been studied in certain clinical and experimental situations. The concentration correlated with pancreatic amylase activity. Low levels were found in patients with malabsorption due to exocrine pancreatic insufficiency. The concentration rose after endoscopic retr...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.1978.tb00868.x

    authors： Borgström A,Ohlsson K

    更新日期：1978-12-01 00:00:00

  • Immune activation and degradation of tryptophan in coronary heart disease.

    abstract：BACKGROUND:Inflammation and immune activation appear to be important in the pathogenesis of coronary heart disease (CHD). Cytokine interferon-gamma, which is released during cell-mediated immune responses, induces indoleamine (2,3)-dioxygenase (IDO), an enzyme degrading tryptophan to kynurenine. Therefore, immune stimu...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1046/j.1365-2362.2003.01186.x

    authors： Wirleitner B,Rudzite V,Neurauter G,Murr C,Kalnins U,Erglis A,Trusinskis K,Fuchs D

    更新日期：2003-07-01 00:00:00

  • Platelets from diabetic subjects show diminished sensitivity to prostacyclin.

    abstract：:Prostacyclin, an unstable metabolite of arachidonic acid metabolism, has been shown to have potent platelet antiaggregatory and vasodilator activity. Available evidence suggests that arterial prostacyclin production is diminished in the diabetic state. In this study we have examined the sensitivity of platelets from d...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.1982.tb00686.x

    authors： Betteridge DJ,El Tahir KE,Reckless JP,Williams KI

    更新日期：1982-10-01 00:00:00

  • Weight reduction, but not a moderate intake of fish oil, lowers concentrations of inflammatory markers and PAI-1 antigen in obese men during the fasting and postprandial state.

    abstract：BACKGROUND:In obese subjects, chronic low-grade inflammation contributes to an increased risk of metabolic abnormalities, which are reversed by weight loss. Sustained weight loss, however, is difficult to achieve and more insight into dietary approaches on anti-inflammatory responses in obese subjects is needed. In thi...

    journal_title：European journal of clinical investigation

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1111/j.1365-2362.2004.01414.x

    authors： Jellema A,Plat J,Mensink RP

    更新日期：2004-11-01 00:00:00

  • NFkappaB, cytokines, TLR 3 and 7 expression in human end-stage HCV and alcoholic liver disease.

    abstract：BACKGROUND/AIMS:Conflicting observations exist concerning the role of nuclear factor kappa B (NFjB) in alcoholic liver disease (ALD) in animal models. To date no studies have examined this aspect in human liver tissue. We here assessed cytokines and toll-like receptors (TLRs) expressions in conjunction with NFkappaB ac...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/j.1365-2362.2010.02295.x

    authors： Stärkel P,De Saeger C,Strain AJ,Leclercq I,Horsmans Y

    更新日期：2010-07-01 00:00:00

  • Antitumour and toxic effects on Wistar rats of two new platinum complexes.

    abstract：BACKGROUND:Cancer chemotherapy in humans based on metal complexes started at the clinical level in the late 1970s with the use of cisplatin, which forms intra-strand cross-links with DNA. METHODS:Two new platinum complexes of cis-geometry with the amino acids inosine (ino) and l-alanine (ala), Pt(ino)2Cl2 and cis-[Pt(...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1046/j.1365-2362.2002.00932.x

    authors： Charalabopoulos K,Karkabounas S,Ioachim E,Papalimneou V,Syrigos K,Evangelou A,Agnantis N,Hadjiliadis N

    更新日期：2002-02-01 00:00:00

  • Effects of high-altitude chronic hypoxia on platelet alpha 2-receptors in man.

    abstract：:During chronic high-altitude (HA) exposure, basal and exercise-induced noradrenaline (NA) increases do not parallel blood pressure (BP) changes observed; unlike beta-adrenergic receptors, to our knowledge no data are available on alpha-receptors. We studied platelet alpha 2- and leucocyte beta-receptors and basal cate...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1046/j.1365-2362.1997.1150663.x

    authors： Zaccaria M,Borea PA,Opocher G,Ponchia A,Varani K,Fraccarollo D,Scandellari C

    更新日期：1997-04-01 00:00:00

  • Temporal changes of soluble ST2 after cardiovascular interventions.

    abstract：BACKGROUND:Soluble ST2 (sST2), a member of the IL-1 receptor family, has been proposed as a novel biomarker with predictive value for heart failure and mortality in patients suffering from cardiovascular diseases. The influence of clinical characteristics on variability of sST2 levels is relatively unexplored. Here, we...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/eci.12022

    authors： Willems S,Sels JW,Flier S,Versteeg D,Buhre WF,de Kleijn DP,Hoefer IE,Pasterkamp G

    更新日期：2013-02-01 00:00:00

  • Soluble TWEAK plasma levels increase after renal transplantation and associate with the improvement of endothelial function.

    abstract：BACKGROUND:Soluble TWEAK (sTWEAK) and asymmetric dimethyl arginine (ADMA) concentrations have been associated with endothelial function in patients with chronic kidney disease (CKD). We tested the hypothesis that the improvement in endothelial function observed after renal transplantation is directly linked to the norm...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/eci.12166

    authors： Yilmaz MI,Sonmez A,Saglam M,Yaman H,Unal HU,Gok M,Cetinkaya H,Eyileten T,Oguz Y,Sari S,Yildirim AO,Vural A,Carrero JJ,Blanco-Colio LM

    更新日期：2013-12-01 00:00:00

  • Uricaemia and ejection fraction in elderly heart failure outpatients.

    abstract：BACKGROUND:Preliminary data suggest that serum uric acid (SUA) could be involved in the prognosis of chronic heart failure (HF). The aim of our study was to test the relationship between SUA and left ventricular ejection fraction (EF%) in a cohort of elderly hypertensive outpatients with chronic HF. DESIGN:We consecut...

    journal_title：European journal of clinical investigation

    pub_type： 杂志文章

    doi：10.1111/eci.12273

    authors： Borghi C,Cosentino ER,Rinaldi ER,Cicero AF

    更新日期：2014-06-01 00:00:00