Effect of acute hyperglycaemia on sensory processing in diabetic autonomic neuropathy.

abstract：AIM:Observationally, low serum testosterone among men is associated with cardiovascular diseases and its risk factors, but it is unclear whether raising endogenous androgens would be protective. To clarify the role of androgens, the association of two different androgen biomarkers (serum testosterone and androstanediol...

journal_title：European journal of clinical investigation

authors： Schooling CM

更新日期：2013-12-01 00:00:00

abstract：:Increased plasma levels of soluble adhesion molecules are associated with an increased risk of atherothrombosis. The pathophysiological mechanisms responsible for these associations are not known. The aim of the present study was to investigate the association of soluble intercellular adhesion molecule-1 (sICAM-1) con...

journal_title：European journal of clinical investigation

authors： Becker A,van Hinsbergh VW,Jager A,Kostense PJ,Dekker JM,Nijpels G,Heine RJ,Bouter LM,Stehouwer CD

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:The ratio of serum C-reactive protein (CRP) to albumin has been proven to be a more accurate indicator than albumin and CRP levels alone in determining the prognosis of patients with cancer and critical illness. The aim of this study was to determine whether the CRP/albumin ratio (CAR) can be linked to imper...

journal_title：European journal of clinical investigation

authors： Karabağ Y,Çağdaş M,Rencuzogullari I,Karakoyun S,Artaç İ,İliş D,Yesin M,Çağdaş ÖS,Altıntaş B,Burak C,Tanboğa HI

更新日期：2018-06-01 00:00:00

abstract：:Reduced glutathione (GSH) and activity of GSH related enzymes play a key role in defence against oxygen free radicals, whose production is, as known, raised in patients affected by diabetes mellitus, and at the same time they may contribute to the process of platelet aggregation. The purpose of this study was to evalu...

journal_title：European journal of clinical investigation

authors： Di Simplicio P,de Giorgio LA,Cardaioli E,Lecis R,Miceli M,Rossi R,Anichini R,Mian M,Seghieri G,Franconi F

更新日期：1995-09-01 00:00:00

abstract：:Efficient fragmentation is the most important prerequisite for successful treatment of gallstones by extracorporeally induced shock waves. No data are available on the amount of energy necessary for stone disintegration and on the threshold energy below which no further fragmentation occurs. We therefore performed an ...

journal_title：European journal of clinical investigation

authors： Neubrand M,Greinwald I,Lobentanzer H,Paumgartner G,Hermeking H,Sauerbruch T

更新日期：1997-03-01 00:00:00

abstract：BACKGROUND:In a previous study, we demonstrated the presence of receptors for somatostatin, a neuropeptide with immunoregulatory properties, in the inflammatory lesions of patients suffering from sarcoidosis and other granulomatous diseases by in vivo somatostatin receptor scintigraphy and in vitro autoradiography. How...

journal_title：European journal of clinical investigation

authors： ten Bokum AM,Hofland LJ,de Jong G,Bouma J,Melief MJ,Kwekkeboom DJ,Schonbrunn A,Mooy CM,Laman JD,Lamberts SW,van Hagen PM

更新日期：1999-07-01 00:00:00

abstract：:We present a sensitive time-resolved fluorometric immunofunctional assay (TR-FIA) for direct quantitation of functional growth hormone-binding protein (GHBP), using an immunoassay kit for growth hormone (GH-DELFIA). In addition to the immobilized GH antibody, one monoclonal antibody against GHBP was used. This anti-GH...

journal_title：European journal of clinical investigation

authors： Fisker S,Frystyk J,Skriver L,Vestbo E,Ho KK,Orskov H

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND:Different studies, mostly cross-sectional, have found an association between low levels of thyroid hormones, even within the normal range, and a greater body mass index. The aim of this study was to determine the association between thyroid function and the risk for obesity. MATERIALS AND METHODS:In this po...

journal_title：European journal of clinical investigation

authors： Soriguer F,Valdes S,Morcillo S,Esteva I,Almaraz MC,de Adana MS,Tapia MJ,Dominguez M,Gutierrez-Repiso C,Rubio-Martin E,Garrido-Sanchez L,Perez V,Garriga MJ,Rojo-Martinez G,Garcia-Fuentes E

更新日期：2011-11-01 00:00:00

abstract：:The stimulant action of branched-chain amino acids upon insulin release was examined in rat pancreatic islets incubated at physiological concentrations of D-glucose and L-glutamine. In the presence of the latter nutrients, L-leucine and L-isoleucine used together at a physiological concentration (0.25 mmol/l each) dou...

journal_title：European journal of clinical investigation

authors： Sener A,Malaisse WJ

更新日期：1981-12-01 00:00:00

abstract：:Oral lichen planus (OLP) is a common oral disorder that manifests a mucosal reaction to a variety of aetiological factors, including liver disorder. This study investigated the relationship between OLP and hepatitis C virus (HCV) infection by studying the prevalence of hepatitis B and C virus infection or liver diseas...

journal_title：European journal of clinical investigation

authors： Nagao Y,Sata M,Tanikawa K,Itoh K,Kameyama T

更新日期：1995-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Microcirculatory changes contribute to clinical symptoms and disease progression in chronic heart failure (CHF). A depression of coronary flow reserve is associated with a lower myocardial capillary density in biopsies. We hypothesized that changes in cardiac microcirculation might also be refl...

journal_title：European journal of clinical investigation

authors： Wadowski PP,Hülsmann M,Schörgenhofer C,Lang IM,Wurm R,Gremmel T,Koppensteiner R,Steinlechner B,Schwameis M,Jilma B

更新日期：2018-02-01 00:00:00

abstract：:Deoxyribonucleic acid synthesis requires adequate cellular concentrations of the four deoxyribonucleoside triphosphates. Using a sensitive enzymic assay, we have measured the concentrations (pools) of these compounds in human bone marrow cells and in lymphocytes. The mean concentrations (pmol/10(6) cells) in normal hu...

journal_title：European journal of clinical investigation

authors： Tattersall MH,Lavoie A,Ganeshaguru K,Tripp E,Hoffbrand AV

更新日期：1975-04-01 00:00:00

abstract：BACKGROUND:We hypothesized the existence of different hormonal response patterns to repeated lower body negative pressure (LBNP) and head-up tilt (HUT) in healthy males. We compared hormonal, cardiovascular and plasma volume changes from rest to stress within- and between-LBNP and HUT applications. Hormones investigate...

journal_title：European journal of clinical investigation

authors： Roessler A,Goswami N,Haditsch B,Loeppky JA,Luft FC,Hinghofer-Szalkay H

更新日期：2011-08-01 00:00:00

abstract：:Resealed erythrocytes are potential slow release carriers for drugs and enzymes. We have investigated carrier erythrocyte survival in human volunteers using gentamicin (G) as encapsulated cell marker; G was readily incorporated into red cells by hypo-osmotic dialysis (87% efficiency of incorporation) and did not exit ...

journal_title：European journal of clinical investigation

authors： Eichler HG,Rameis H,Bauer K,Korn A,Bacher S,Gasić S

更新日期：1986-02-01 00:00:00

abstract：:The change in bone mass during 1 1/2 years was determined in a longitudinal study of sixty adult insulin-treated diabetic out-patients. During the study period the mean bone mass decreased by 1.30 +/- 0.28 (SEM)% (P less than 0.001), to a mean value of 91.0 +/- 1.7% of normal (P less than 0.001). The rate of bone loss...

journal_title：European journal of clinical investigation

authors： McNair P,Christiansen C,Christensen MS,Madsbad S,Faber OK,Binder C,Transbøl I

更新日期：1981-02-01 00:00:00

abstract：BACKGROUND:Acute myocardial infarction (AMI) is followed by post AMI cardiac remodelling, often leading to congestive heart failure. Homing of c-kit+ endothelial progenitor cells (EPC) has been thought to be the optimal source for regenerating infarcted myocardium. METHODS:Immune function of viable peripheral blood mo...

journal_title：European journal of clinical investigation

authors： Ankersmit HJ,Hoetzenecker K,Dietl W,Soleiman A,Horvat R,Wolfsberger M,Gerner C,Hacker S,Mildner M,Moser B,Lichtenauer M,Podesser BK

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:Carotid intima-media thickness and carotid plaque are well-established imaging markers used to capture different stages of the atherosclerotic disease process. We aimed to quantify to which extent carotid intima-media thickness predicts incidence of first-ever carotid plaque. MATERIALS AND METHODS:Two indep...

journal_title：European journal of clinical investigation

authors： Tschiderer L,Klingenschmid G,Seekircher L,Willeit P

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Disuse and/or local inflammation in the muscle cannot be excluded as potential influences for the decreased muscle force in patients hospitalised due to an acute chronic obstructive pulmonary disease (COPD) exacerbation. This study aims to compare expression levels of markers of disuse (insulin-like growth f...

journal_title：European journal of clinical investigation

authors： Crul T,Spruit MA,Gayan-Ramirez G,Quarck R,Gosselink R,Troosters T,Pitta F,Decramer M

更新日期：2007-11-01 00:00:00

abstract：:The work was designed to study the effects of a meat meal on glomerular filtration rate (GFR), renal plasma flow (RPF), and plasma concentrations of glucagon, insulin, growth hormone, renin, aldosterone, total amino acids, and NH3 in healthy humans (H) as well as in patients with Child A liver cirrhosis (LC). The meat...

journal_title：European journal of clinical investigation

authors： De Santo NG,Anastasio P,Loguercio C,del Vecchio Blanco C,Capasso G,Coppola S,Bellini L,Spagnuolo G,Federico P,Alfieri R

更新日期：1992-01-01 00:00:00

abstract：:A kindred in which several members have otherwise typical acute intermittent porphyria but normal erythrocyte uroporphyrinogen-I-synthase activity has been described from Finland. We studied two porphyric members of this kindred, two patients with typical acute intermittent porphyria, and two healthy controls using th...

journal_title：European journal of clinical investigation

authors： Mustajoki P,Tenhunen R

更新日期：1985-10-01 00:00:00

abstract：:Based on pathophysiological findings Lp(a) is considered to be a cardiovascular risk factor. The Göttingen Risk Incidence and Prevalence Study (GRIPS) provides the possibility to evaluate this impact of Lp(a) on the basis of a large prospective cohort study. GRIPS included 6002 men, aged 40-59.9 years at baseline. Dat...

journal_title：European journal of clinical investigation

authors： Cremer P,Nagel D,Labrot B,Mann H,Muche R,Elster H,Seidel D

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND:The cholesterol-esterifying enzyme, lecithin:cholesterol acyltransferase (LCAT), is instrumental in high-density lipoprotein (HDL) remodelling. LCAT may also modify oxidative and inflammatory processes, as supported by an inverse relationship with HDL antioxidative functionality and a positive relationship w...

journal_title：European journal of clinical investigation

authors： Gruppen EG,Connelly MA,Otvos JD,Bakker SJ,Dullaart RP

更新日期：2015-08-01 00:00:00

abstract：:Synthetic stable analogues of thromboxane A2 (TXA2), cyclic endoperoxides (PGH2) and prostacyclin (PGI2) opened up new opportunities for investigating the mechanisms of action of these compounds. They proved to be useful pharmacological probes for characterizing PGI2 and TXA2/PGH2 receptors. Over the past few years, n...

journal_title：European journal of clinical investigation

authors： Jaschonek K,Muller CP

更新日期：1988-02-01 00:00:00

abstract：:Lipid and carbohydrate metabolism variables were studied in twenty-eight patients with chronic renal failure (mean GFR 7.7 +/- 2.5 ml/min) and uraemic symptoms. 71% of the patients had hypertriglyceridaemia (greater than or equal to 2.2 mmol/l). Total serum cholesterol was normal while VLDL cholesterol was high and al...

journal_title：European journal of clinical investigation

authors： Attman PO,Gustafson A

更新日期：1979-08-01 00:00:00

abstract：:The ATP-binding cassette transporter P-glycoprotein is now recognized as an important determinant for disposition of multiple drugs. The use of P-glycoprotein-expressing cell lines, the generation of P-glycoprotein knockout mice as well as studies in animals and humans contributed to a better understanding on the role...

journal_title：European journal of clinical investigation

authors： Fromm MF

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND:Observational studies have shown that high levels of serum uric acid (UA) were associated with atrial fibrillation (AF). However, the causal effect of urate on the risk of AF is still unknown. To clarify the potential causal association between UA and AF, we performed a Mendelian randomization (MR) analysis ...

journal_title：European journal of clinical investigation

authors： Hong M,Park JW,Yang PS,Hwang I,Kim TH,Yu HT,Uhm JS,Joung B,Lee MH,Jee SH,Pak HN

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:Kinetic abnormalities of apolipoprotein B (apoB)-containing lipoproteins in noninsulin-dependent diabetes mellitus (NIDDM) remain poorly understood. To get further insight into these abnormalities we performed a stable isotope kinetic experiment comparing the metabolism of apoB-containing lipoproteins in mod...

journal_title：European journal of clinical investigation

authors： Duvillard L,Pont F,Florentin E,Galland-Jos C,Gambert P,Vergès B

更新日期：2000-08-01 00:00:00

abstract：BACKGROUND:Intestinal commensal flora seems to be a requisite for both human and experimental intestinal inflammation. Our aim was to assess the immunological changes in the colon of IL-10(-/-) mice depending on the environmental conditions. MATERIALS AND METHODS:Twelve wild-type (WT) and 24 IL-10(-/-) 4-week-old mice...

journal_title：European journal of clinical investigation

authors： Pedrosa E,Lorén V,Cabré E,Doménech E,Ojanguren I,Gassull MA,Mañé J

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:Several clinical trials have suggested that a metabolic cocktail of glucose-insulin-potassium (GIK) decreases mortality rates in patients with acute myocardial infarction (AMI). It has also been reported that Fas-mediated apoptosis plays an important role in ischaemic/reperfusion injury in the rat model. Thi...

journal_title：European journal of clinical investigation

authors： Zhang L,Zhang L,Li YH,Zhang HY,Chen ML,Gao MM,Hu AH,Yang HS,Yang HS

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:Plasma brain natriuretic peptide (BNP) is elevated in asymptomatic patients with various cardiac abnormalities. We tested the hypothesis that measuring BNP is useful for detecting asymptomatic patients with cardiac abnormalities who are not identified by conventional health check-up programmes. MATERIALS AN...

journal_title：European journal of clinical investigation

authors： Takase H,Toriyama T,Sugiura T,Takahashi A,Sugiyama M,Ohashi M,Ueda R,Dohi Y

更新日期：2007-04-01 00:00:00