Importance of P-glycoprotein for drug disposition in humans.

abstract：BACKGROUND:Nowadays there is an increased interest in the role of aortic stiffness in the pathophysiology of heart failure (HF), as it is a major determinant of left ventricular (LV) performance. We aimed at assessing the predictive value of the aortic stiffness parameters, measured by echocardiography, in patients aff...

journal_title：European journal of clinical investigation

authors： Sciatti E,Vizzardi E,Bonadei I,Fabbricatore D,Prati F,Pagnoni M,Metra M

更新日期：2018-07-01 00:00:00

abstract：:The study aimed to assess vascular reactivity to noradrenaline with and without neuropeptide Y in diabetic rats, and to determine whether any abnormality could be attributed to insulin deficiency or to hyperglycaemia per se. The authors compared non-diabetic rats (n = 9) and rats with streptozotocin-induced diabetes t...

journal_title：European journal of clinical investigation

authors： Savage MW,Bodmer CW,Walker AB,Buchan IE,Masson EA,Williams G

更新日期：1995-12-01 00:00:00

abstract：:In controls and in patients suffering from congestive heart failure (CHF) the circulating levels of catecholamines, neuropeptide Y-like immunoreactivity (NPY-LI), vasoactive intestinal peptide-LI (VIP-LI), substance P-LI (SP-LI) and calcitonin generated peptide-LI (CGRP-LI) markers of sympathetic, parasympathetic and ...

journal_title：European journal of clinical investigation

authors： Edvinsson L,Ekman R,Hedner P,Valdemarsson S

更新日期：1990-02-01 00:00:00

abstract：BACKGROUND:The pathogenesis of tumour formation in the anterior pituitary including adrenocorticotropic hormone (ACTH)-secreting tumours has been intensively studied, but the causative mechanisms involved in pituitary cell transformation and tumourigenesis remain unclear. MATERIALS AND METHODS:We searched PubMed on an...

journal_title：European journal of clinical investigation

authors： Dworakowska D,Grossman AB

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Cardiac resynchronization therapy (CRT) is an established therapy for advanced congestive heart failure, improving both survival and hospitalization. The mechanism beneath these improvements still needs to be defined as about one-third of the patients do not benefit from resynchronization. Restoration of sym...

journal_title：European journal of clinical investigation

authors： Martignani C,Diemberger I,Nanni C,Biffi M,Ziacchi M,Boschi S,Corzani A,Fanti S,Sambuceti G,Boriani G

更新日期：2015-08-01 00:00:00

abstract：:Bombesin was originally isolated from amphibian skin, whereas its mammalian counterpart, gastrin-releasing peptide (GRP), was first identified in the nervous system of the gastrointestinal tract. Whether GRP is present in the human skin is not known. Bombesin-like peptides are also known to modulate growth. We therefo...

journal_title：European journal of clinical investigation

authors： Pansky A,Peng F,Eberhard M,Baselgia L,Siegrist W,Baumann JB,Eberle AN,Beglinger C,Hildebrand P

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Different studies, mostly cross-sectional, have found an association between low levels of thyroid hormones, even within the normal range, and a greater body mass index. The aim of this study was to determine the association between thyroid function and the risk for obesity. MATERIALS AND METHODS:In this po...

journal_title：European journal of clinical investigation

authors： Soriguer F,Valdes S,Morcillo S,Esteva I,Almaraz MC,de Adana MS,Tapia MJ,Dominguez M,Gutierrez-Repiso C,Rubio-Martin E,Garrido-Sanchez L,Perez V,Garriga MJ,Rojo-Martinez G,Garcia-Fuentes E

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:Glucocorticosteroids are effective in the treatment of allergic rhinitis, a disease characterized by a variety of symptoms, e.g. rhinorrhea and itching. The time course of symptomatic relief for allergic rhinitis by steroids has not been examined in detail to date, although the onset of steroid action is one...

journal_title：European journal of clinical investigation

authors： Tillmann HC,Stuck BA,Feuring M,Rossol-Haseroth K,Tran BM,Lösel R,Schmidt BM,Hörmann K,Wehling M,Schultz A

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:The use of Procion orange dye (POD) is one of the most widely accepted techniques to assess sarcolemmal damage. This phenomenon has been related to functional adaptation in skeletal muscles. The POD method includes intravenous injection of this colorant in vivo, enabling its identification inside those fibre...

journal_title：European journal of clinical investigation

authors： Palacio J,Gāldiz JB,Alvarez FJ,Orozco-Levi M,Lloreta J,Gea J

更新日期：2002-06-01 00:00:00

abstract：BACKGROUND:To prospectively evaluate the role of procalcitonin (PCT) in screening of patients with thyroid nodules for medullary thyroid carcinoma (MTC). MATERIALS AND METHODS:We measured PCT in 2705 patients with thyroid nodules referred to our centre between January 2011 and December 2017. Those with a positive PCT ...

journal_title：European journal of clinical investigation

authors： Giovanella L,Imperiali M,Piccardo A,Taborelli M,Verburg FA,Daurizio F,Trimboli P

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Chronic hyperglycaemia in diabetes is suggested to be a major cause of diabetic angiopathy. Up until now, the effects of acutely induced hyperglycaemia in non-diabetic subjects as well as hyperglycaemic effects in early diabetes, on mesenteric microcirculation and leucocyte endothelial cell interaction have ...

journal_title：European journal of clinical investigation

authors： Schäffler A,Arndt H,Schölmerich J,Palitzsch K

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND:Increasing evidence indicates that nonalcoholic fatty liver disease (NAFLD) is linked to an increased risk of extra-hepatic conditions. However, it is currently uncertain whether NAFLD is associated with the risk of gastroesophageal reflux disease (GERD). We performed a systematic review and meta-analysis of...

journal_title：European journal of clinical investigation

authors： Xue J,Xin H,Ren N,Zhou C,Yang J,Song L,Qin S

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:The red cell distribution width (RDW) predicts mortality among many populations. RDW is calculated as the standard deviation (SD) of the red blood cell (RBC) volume divided by mean corpuscular volume (MCV). Because higher MCV also predicts mortality, we hypothesized that the RDW numerator (one SD of RBC volu...

journal_title：European journal of clinical investigation

authors： Horne BD,Muhlestein JB,Bennett ST,Muhlestein JB,Ronnow BS,May HT,Bair TL,Anderson JL

更新日期：2015-06-01 00:00:00

abstract：:Postural changes in plasma renin activity were studied in three groups of age and duration-matched male diabetics (potent, impotent and with postural hypotension) and in non-diabetic control subjects. Those diabetic subjects with postural hypotension due to automatic neuropathy had no increase in plasma renin activity...

journal_title：European journal of clinical investigation

authors： Campbell IW,Ewing DJ,Anderton JL,Thompson JH,Horn DB,Clarke BF

更新日期：1976-09-10 00:00:00

abstract：BACKGROUND:Complement fragment C5a and neutrophils have been implicated in the pathogenesis of renal disease and C5a has also been shown to delay apoptosis of human neutrophils via a transcription-independent pathway. However, transcription-dependent pathways have not been well described. The present study examined whe...

journal_title：European journal of clinical investigation

authors： Perianayagam MC,Madias NE,Pereira BJ,Jaber BL

更新日期：2006-05-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to compare the prevalence of lumbar spondylolisthesis (SPL) in patients suffering from low back pain (LBP) with or without rheumatoid arthritis (RA) and to identify potential factors associated with SPL in patients with RA. METHODS:We performed a case-control study. Cases and contro...

journal_title：European journal of clinical investigation

authors： Hagege B,Tubach F,Alfaiate T,Forien M,Dieudé P,Ottaviani S

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:There are close interrelationships between hormones that regulate bone formation and protein biosynthesis. For example, growth hormone and thyroid hormones can influence plasma levels of insulin-like growth factor-I (IGF-I). A patient's status regarding hormones other than IGF-I may thus indirectly modify th...

journal_title：European journal of clinical investigation

authors： Svanberg E,Healey J,Mascarenhas D

更新日期：2001-04-01 00:00:00

abstract：:Thyroid hormones occasionally appear less effective when administered alone to patients with panhypopituitarism, and manifestations suggestive of hypothyroidism have been reported in patients suffering from untreated Addison's disease. In the latter condition, thyrotropin secretion is increased: this occurs already af...

journal_title：European journal of clinical investigation

authors： De Nayer P,Dozin B,Vandeput Y,Bottazzo FC,Crabbe J

更新日期：1987-04-01 00:00:00

abstract：BACKGROUND:Advanced glycation end-products (AGEs) are increased in situations with hyperglycemia and oxidative stress such as diabetes mellitus. They are products of nonenzymatic glycation and oxidation of proteins and lipids. The kidney plays an important role in clearance and metabolism of AGEs. METHODS:Medline and ...

journal_title：European journal of clinical investigation

authors： Busch M,Franke S,Rüster C,Wolf G

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:Angiogenesis is essential for tumour growth and metastasis, and is coordinated by several classes of growth factors mediating their effect through receptors linked, in turn, to tyrosine kinase. These growth factors include angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2) and vascular endothelial growth factor ...

journal_title：European journal of clinical investigation

authors： Caine GJ,Blann AD,Stonelake PS,Ryan P,Lip GY

更新日期：2003-10-01 00:00:00

abstract：:Investigations were carried out to analyse the interactions of alpha 2-antagonists (yohimbine, idazoxan, SK & F-86,466) with human fat cell alpha 2-adrenoceptors. All the alpha 2-antagonists enhanced the lipolytic potencies of epinephrine with an order of potency: yohimbine greater than idazoxan greater than SK & F-86...

journal_title：European journal of clinical investigation

authors： Galitzky J,Taouis M,Berlan M,Rivière D,Garrigues M,Lafontan M

更新日期：1988-12-01 00:00:00

abstract：BACKGROUND:Soluble ST2 (sST2), a member of the IL-1 receptor family, has been proposed as a novel biomarker with predictive value for heart failure and mortality in patients suffering from cardiovascular diseases. The influence of clinical characteristics on variability of sST2 levels is relatively unexplored. Here, we...

journal_title：European journal of clinical investigation

authors： Willems S,Sels JW,Flier S,Versteeg D,Buhre WF,de Kleijn DP,Hoefer IE,Pasterkamp G

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:To compare the administration of furosemide with placebo on the subjective perception of dyspnoea in patients with acute pulmonary oedema because of hypertensive crisis. Design  Randomized, controlled and double-blinded clinical trial. SETTING:Municipal emergency medical service system and university-based ...

journal_title：European journal of clinical investigation

authors： Holzer-Richling N,Holzer M,Herkner H,Riedmüller E,Havel C,Kaff A,Malzer R,Schreiber W

更新日期：2011-06-01 00:00:00

abstract：:Fibromuscular dysplasia (FMD) is an idiopathic, segmental, non-atherosclerotic and non-inflammatory disease of the musculature of arterial walls, leading to stenosis of small and medium-sized arteries, mostly involving renal and cervical arteries. As a result of better and more systematic screening, it appears that in...

journal_title：European journal of clinical investigation

authors： Van der Niepen P,van Tussenbroek F,Devos H,Debing E,Di Monaco S,Goffette P,Astarci P,Persu A

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Thiopurines (TP) are widely used in the management of inflammatory bowel diseases. Side effects and inefficacy are a major concern as they lead to withdrawal of the drug. MATERIALS AND METHODS:Tools investigating TP metabolism are useful to avoid inadequate cessation of TP therapy. RESULTS:TP metabolism is...

journal_title：European journal of clinical investigation

authors： Dewit O,Starkel P,Roblin X

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:The accuracy of estimating glomerular filtration rate from plasma creatinine (eGFR) has been questioned but it is unclear how much covert error in several reference methods that have been used has contributed to this perceived inaccuracy. The aim of the study was to evaluate eGFR in comparison with a second ...

journal_title：European journal of clinical investigation

authors： Bird NJ,Peters C,Michell AR,Peters AM

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:Burnout represents a syndrome that is related to demanding job characteristics combined with the absence of resources or motivational job characteristics. The aim of this position study was to present strategies that individuals use to minimize burnout and its unfavourable effects. MATERIALS AND METHODS:The...

journal_title：European journal of clinical investigation

authors： Demerouti E

更新日期：2015-10-01 00:00:00

abstract：:The in situ intraperitoneal volume and the mass transfer area coefficients (MTC) of urea, lactate, creatinine, glucose, kanamycin, inulin, beta 2-microglobulin, albumin and IgG were studied in eight continuous ambulatory peritoneal dialysis (CAPD) patients. All patients were studied during a 4-h dialysis dwell, first ...

journal_title：European journal of clinical investigation

authors： Krediet RT,Zuyderhoudt FM,Boeschoten EW,Arisz L

更新日期：1987-02-01 00:00:00

abstract：AIMS:This study estimated the resource implications and budget impact of managing adults with Fabry disease in Italy, from the perspective of the Servizio Sanitario Nazionale (SSN). METHODS:A decision model was constructed using published clinical outcomes and clinician-derived resource utilisation estimates depicting...

journal_title：European journal of clinical investigation

authors： Guest JF,Concolino D,Di Vito R,Feliciani C,Parini R,Zampetti A

更新日期：2011-07-01 00:00:00

abstract：:Total serum haemolytic complement activity, plasma fibrinogen, erythrocyte sedimentation rate and other biological values in forty-three patients with Hodgkin's disease were correlated with results of staging. A highly significant increase (P=10(-5)) of the mean total serum haemolytic complement activity was found in ...

journal_title：European journal of clinical investigation

authors： Wagener DJ,Haanen C

更新日期：1977-08-01 00:00:00