Anabolic effects of rhIGF-I/IGFBP-3 in vivo are influenced by thyroid status.

abstract：:The nephrotic syndrome is frequently associated with hyperlipidaemia and hyperfibrinogenaemia, leading to an increased coronary and thrombotic risk, which may be enhanced by high lipoprotein (a) [Lp(a)] concentrations. We followed the quantitative and qualitative pattern of plasma lipoproteins over 18 months in a pati...

journal_title：European journal of clinical investigation

authors： Thiery J,Ivandic B,Bahlmann G,Walli AK,Seidel D

更新日期：1996-04-01 00:00:00

abstract：:The formation of metabolites of arachidonic acid by the cyclo-oxygenase and lipoxygenase pathways were determined in human lung tissue, obtained from surgery. In this measurement the chopped tissue was incubated with the calcium ionophore A23187. Formation of metabolites from [1-14C] arachidonic acid was also determin...

journal_title：European journal of clinical investigation

authors： Zijlstra FJ,Naaktgeboren M,Mons H,Vincent JE

更新日期：1987-08-01 00:00:00

abstract：BACKGROUND:Neutrophil-mediated inflammation was recently identified as an active contributor to athero-progression. Therapeutic strategies inhibiting neutrophil degranulation or recruitment were hypothesized to positively impact on plaque vulnerability. In this study, we investigated whether treatment with the recently...

journal_title：European journal of clinical investigation

authors： Da Silva AR,Lenglet S,Carbone F,Burger F,Roth A,Liberale L,Bonaventura A,Dallegri F,Stergiopulos N,Santos RA,Mach F,Fraga-Silva RA,Montecucco F

更新日期：2017-02-01 00:00:00

abstract：:Obesity is a multifactorial disease with a marked genetic component. The situation is further complicated by the heterogeneity of obesity demonstrated by the topographical distribution of body fat, e.g. upper body (central) and lower body (gluteal) obesity. Furthermore, the distribution of fat shows a stronger heritab...

journal_title：European journal of clinical investigation

authors： Weaver JU,Kopelman PG,Hitman GA

更新日期：1992-04-01 00:00:00

abstract：:The venous system plays a pivotal role in volume and blood pressure homeostasis. We tested the hypothesis that the visco-elastic properties of the peripheral venous system are reduced in patients with (incipient) diabetic nephropathy. Twenty-two normotensive patients with long-term insulin-dependent diabetes mellitus ...

journal_title：European journal of clinical investigation

authors： Schaper NC,Houben AJ,Schoon Y,Kooman JP,Huvers FC,Nieuwenhuijzen Kruseman AC

更新日期：1994-06-01 00:00:00

abstract：:Duchenne muscular dystrophy (DMD) is an X-linked muscle disorder characterized by progressive, irreversible loss of cardiac and skeletal muscular function. Muscular enlargement in DMD is attributed to oedema, due to the increased cytoplasmic Na+ concentration. The aim of this review was to present the current experien...

journal_title：European journal of clinical investigation

authors： Mavrogeni S,Papavasiliou A,Giannakopoulou K,Markousis-Mavrogenis G,Pons MR,Karanasios E,Nikas I,Papadopoulos G,Kolovou G,Chrousos GP

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Recent studies in mice experimental models with acute ischaemic injury revealed that erythropoietin (EPO) has numerous tissue-protective effects in the heart, brain and kidneys. We therefore explored the tissue-protective properties of chronic EPO treatment in an experimental model of the db/db mouse with di...

journal_title：European journal of clinical investigation

authors： Shushakova N,Park JK,Menne J,Fliser D

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:Studies in different animal models and plasma analyses in humans suggest that members of the interleukin-6 (IL-6) cytokine family may be involved in the pathogenesis of congestive heart failure (CHF). Accordingly, we have examined IL-6-related cytokines in chronic CHF in humans by analysing gene and protein ...

journal_title：European journal of clinical investigation

authors： Eiken HG,Øie E,Damås JK,Yndestad A,Bjerkeli V,Aass H,Simonsen S,Geiran OR,Tønnessen T,Christensen G,Frøland SS,Gullestad L,Attramadal H,Aukrust P

更新日期：2001-05-01 00:00:00

abstract：:The in vivo metabolism in the rat of radioiodinated human and rat high-density lipoprotein was compared with a double-label procedure using 125I and 131I. While rat high-density lipoprotein showed a biphasic serum decay, human high-density lipoprotein was characterized by a monoexponential serum decay. No differences ...

journal_title：European journal of clinical investigation

authors： van't Hooft FM,van Tol A

更新日期：1985-12-01 00:00:00

abstract：BACKGROUND:Increased production of chemokines by adipose tissue and defective adipose tissue oxygenation as a result of obesity may induce leucocyte infiltration and subsequent systemic inflammation. OBJECTIVES:1-To determine the relation between the amount of visceral and subcutaneous adipose tissue and the chemokine...

journal_title：European journal of clinical investigation

authors： Faber DR,van der Graaf Y,Westerink J,Kanhai DA,Monajemi H,Visseren FL,SMART study Group.

更新日期：2013-04-01 00:00:00

abstract：:Resealed erythrocytes are potential slow release carriers for drugs and enzymes. We have investigated carrier erythrocyte survival in human volunteers using gentamicin (G) as encapsulated cell marker; G was readily incorporated into red cells by hypo-osmotic dialysis (87% efficiency of incorporation) and did not exit ...

journal_title：European journal of clinical investigation

authors： Eichler HG,Rameis H,Bauer K,Korn A,Bacher S,Gasić S

更新日期：1986-02-01 00:00:00

abstract：BACKGROUND:Early menopause, whether it be natural or surgical, is one of the established risk factors for osteoporosis. Surgical menopause, however, differs from natural menopause owing to the abrupt cessation of estrogen secretion. This study attempts to investigate the influence of menopause type on bone mineral dens...

journal_title：European journal of clinical investigation

authors： Hadjidakis D,Kokkinakis E,Sfakianakis M,Raptis SA

更新日期：1999-10-01 00:00:00

abstract：:Primary biliary cirrhosis and primary sclerosing cholangitis are well recognized chronic cholestatic liver diseases that are considered to have an autoimmune basis. Recent progress in the study of autoimmune liver diseases has improved the recognition and characterization of these conditions. An important component of...

journal_title：European journal of clinical investigation

authors： Medina J,Jones EA,García-Monzón C,Moreno-Otero R

更新日期：2001-01-01 00:00:00

abstract：:Bradykinin infusion has been shown to improve glucose metabolism in non-insulin-dependent diabetic subjects (NIDD). Therefore, we tested the following hypothesis: inhibition of Kininase II, the bradykinin (BK) degrading enzyme, by captopril may also improve glucose metabolism in NIDD. Immediate effects of captopril on...

journal_title：European journal of clinical investigation

authors： Jauch KW,Hartl W,Guenther B,Wicklmayr M,Rett K,Dietze G

更新日期：1987-10-01 00:00:00

abstract：BACKGROUND:Minimal lipoprotein(a) [Lp(a)] target values are advocated for high-risk cardiovascular patients. We investigated the prognostic value of Lp(a) in the acute setting of patients with acute coronary syndromes (ACS). MATERIALS AND METHODS:Plasma levels of Lp(a) were collected at time of angiography from 1711 p...

journal_title：European journal of clinical investigation

authors： Gencer B,Rigamonti F,Nanchen D,Vuilleumier N,Kern I,Aghlmandi S,Klingenberg R,Räber L,Auer R,Carballo D,Carballo S,Heg D,Windecker S,Lüscher TF,Matter CM,Rodondi N,Mach F

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Alcohol may have a cardioprotective effect. One possible mechanism is by modifying insulin resistance/secretion. The aims of this study were: (i) to examine the effect of short-term alcohol consumption on the metabolic control of glucose tolerance; (ii) to study the influence of short-term alcohol consumptio...

journal_title：European journal of clinical investigation

authors： Flanagan DE,Pratt E,Murphy J,Vaile JC,Petley GW,Godsland IF,Kerr D

更新日期：2002-03-01 00:00:00

abstract：:To assess the degree of immune system activation associated with addiction or hepatotropic viruses infection, we examined 60 HIV-negative heroin addicts for the presence of hepatitis B virus (HBV) infection markers, hepatitis C virus antibodies (anti-HCV), various auto-antibodies, and serum levels of soluble interleuk...

journal_title：European journal of clinical investigation

authors： Dalekos GN,Manoussakis MN,Zervou E,Tsianos EV,Moutsopoulos HM

更新日期：1993-04-01 00:00:00

abstract：BACKGROUND:The ratio of serum C-reactive protein (CRP) to albumin has been proven to be a more accurate indicator than albumin and CRP levels alone in determining the prognosis of patients with cancer and critical illness. The aim of this study was to determine whether the CRP/albumin ratio (CAR) can be linked to imper...

journal_title：European journal of clinical investigation

authors： Karabağ Y,Çağdaş M,Rencuzogullari I,Karakoyun S,Artaç İ,İliş D,Yesin M,Çağdaş ÖS,Altıntaş B,Burak C,Tanboğa HI

更新日期：2018-06-01 00:00:00

abstract：:The pathobiochemical mechanism of arteriosclerosis in hyperhomocysteinaemia has not yet been elucidated. In vitro studies have shown that the cytotoxic properties of homocysteine can be ascribed to its generation of reactive oxygen species. We studied lipid peroxidation, both in vivo and in vitro, in 10 homozygous cys...

journal_title：European journal of clinical investigation

authors： Blom HJ,Kleinveld HA,Boers GH,Demacker PN,Hak-Lemmers HL,Te Poele-Pothoff MT,Trijbels JM

更新日期：1995-03-01 00:00:00

abstract：:Testosterone levels are decreased in obese men but increased in obese women. The interplay between gonadal steroids and leptin is, at present, far from being elucidated. This study was carried out to investigate the relationship between serum leptin, plasma insulin, insulin sensitivity and free testosterone in 46 men ...

journal_title：European journal of clinical investigation

authors： Vettor R,De Pergola G,Pagano C,Englaro P,Laudadio E,Giorgino F,Blum WF,Giorgino R,Federspil G

更新日期：1997-12-01 00:00:00

abstract：BACKGROUND:Different time-concentration profiles of plasma insulin following insulin modification of a frequently sampled intravenous glucose-tolerance-test (FSIVGTT) were observed in a study investigating maternal metabolism and fetal macrosomia. We aimed to investigate whether these differences were related to the vo...

journal_title：European journal of clinical investigation

authors： Jolly MC,Hovorka R,Godsland I,Amin R,Lawrence N,Anyaoku V,Johnston D,Robinson S

更新日期：2003-08-01 00:00:00

abstract：BACKGROUND:Urotensin II plays a role in myocardial remodelling. Cardiac fibroblasts play a critical role in the development of cardiac fibrosis. The effect of hypoxia on urotensin II expression in cardiac fibroblasts is poorly understood. We sought to investigate the regulation of urotensin II by hypoxia in cardiac fib...

journal_title：European journal of clinical investigation

authors： Shyu KG,Wang BW,Chen WJ,Kuan P,Lin CM

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Arterial stiffness is an important determinant of cardiovascular risk. It is associated with several cardiovascular risk factors, including hypertension, diabetes and cigarette smoking. However, there are conflicting data about the relationship between arterial stiffness and hypercholesterolemia. Furthermore...

journal_title：European journal of clinical investigation

authors： Riggio S,Mandraffino G,Sardo MA,Iudicello R,Camarda N,Imbalzano E,Alibrandi A,Saitta C,Carerj S,Arrigo T,Saitta A

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:Elevated pregnancy-associated plasma protein A (PAPP-A) levels are associated with increased risk of death in ischaemic heart disease as well as in haemodialysis patients. Previous research indicates that the prognostic value of PAPP-A may be stronger in patients with concomitant diabetes mellitus or signs o...

journal_title：European journal of clinical investigation

authors： Nilsson E,Rudholm T,Stenvinkel P,Ärnlöv J

更新日期：2018-08-01 00:00:00

abstract：:Pulmonary plasma kinetics of endogenous noradrenaline (NA) and tritium labelled L-noradrenaline (3H-NA) was studied in fifteen subjects during pulmonary arterial catheterization. Plasma NA concentration in femoral artery ranged from 0.5 to 8.2 nmol l-1, mean 2.3 nmol l-1, which was not significantly different from tha...

journal_title：European journal of clinical investigation

authors： Henriksen JH,Christensen NJ,Ring-Larsen H

更新日期：1986-10-01 00:00:00

abstract：BACKGROUND:This study was conducted to determine the effects of fish oil administration on gene expression related to insulin, lipid and inflammation in women with polycystic ovary syndrome (PCOS). MATERIALS AND METHODS:This randomized, double-blind, placebo-controlled trial was conducted among 40 subjects with PCOS, ...

journal_title：European journal of clinical investigation

authors： Rahmani E,Jamilian M,Dadpour B,Nezami Z,Vahedpoor Z,Mahmoodi S,Aghadavod E,Taghizadeh M,Beiki Hassan A,Asemi Z

更新日期：2018-03-01 00:00:00

abstract：:The concentration in serum of cathodal trypsinogen has been studied in certain clinical and experimental situations. The concentration correlated with pancreatic amylase activity. Low levels were found in patients with malabsorption due to exocrine pancreatic insufficiency. The concentration rose after endoscopic retr...

journal_title：European journal of clinical investigation

authors： Borgström A,Ohlsson K

更新日期：1978-12-01 00:00:00

abstract：:The classical view of aldosterone actions via the mineralocorticoid receptor (MR) limited to control of fluid balance and blood pressure homoeostasis has been progressively overcome by clinical and experimental evidence emphasizing the pleiotropic role of MR activation in the pathogenesis of cardiovascular disease. Cl...

journal_title：European journal of clinical investigation

authors： Galuppo P,Bauersachs J

更新日期：2012-10-01 00:00:00

abstract：:In a prospective study we investigated the possible changes in fasting serum total homocysteine concentrations during continuous micronized 17 beta-oestradiol, 2 mg daily, in combination with cyclic dydrogesterone, 10 mg daily during the first 14 days of each 28 day cycle, in 21 healthy non-hysterectomized postmenopau...

journal_title：European journal of clinical investigation

authors： van der Mooren MJ,Wouters MG,Blom HJ,Schellekens LA,Eskes TK,Rolland R

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND:Adiponectin is an insulin-sensitizing, antiatherogenic and anti-inflammatory adipocytokine that circulates in three isoforms: a trimer [low-molecular weight (LMW)], a hexamer (trimer-dimer) of medium molecular weight (MMW) and a multimeric high molecular weight (HMW) isoform. Evidence is accumulating that HM...

journal_title：European journal of clinical investigation

authors： Kaser S,Tatarczyk T,Stadlmayr A,Ciardi C,Ress C,Tschoner A,Sandhofer A,Paulweber B,Ebenbichler CF,Patsch JR

更新日期：2008-11-01 00:00:00