Abstract:
:The venous system plays a pivotal role in volume and blood pressure homeostasis. We tested the hypothesis that the visco-elastic properties of the peripheral venous system are reduced in patients with (incipient) diabetic nephropathy. Twenty-two normotensive patients with long-term insulin-dependent diabetes mellitus (IDDM), 11 without and 11 with (incipient) nephropathy (eight microalbuminuria and three proteinuria, serum creatinine below 100 mumol l-1), and 14 healthy age/sex matched controls were studied. Forearm venous compliance (VENCOMP) was determined using strain gauge plethysmography and direct intravenous pressure measurements. Furthermore, the venodilatory effect of 0.4 mg sublingual nitroglycerin (NTG) was studied. In comparison with healthy controls, VENCOMP was decreased in patients without and with (incipient) nephropathy, without any differences between the two diabetic groups: 0.059 (0.052-0.066), 0.044 (0.038-0.059) and 0.049 (0.046-0.058) ml 100 ml-1 mmHg-1, respectively (medians and interquartile ranges) (P < 0.05). No differences in the increase of forearm volume after NTG were observed: 0.34 (0.11-0.51), 0.37 (0.19-0.50) and 0.39 (0.20-0.55) ml 100 ml-1, respectively. In conclusion, the visco-elastic properties of the peripheral venous system are reduced in patients with long-term IDDM. This reduction is not related to the presence of nephropathy. No major differences were observed in NTG-induced venodilation between diabetic patients and healthy subjects.
journal_name
Eur J Clin Investjournal_title
European journal of clinical investigationauthors
Schaper NC,Houben AJ,Schoon Y,Kooman JP,Huvers FC,Nieuwenhuijzen Kruseman ACdoi
10.1111/j.1365-2362.1994.tb02180.xsubject
Has Abstractpub_date
1994-06-01 00:00:00pages
382-7issue
6eissn
0014-2972issn
1365-2362journal_volume
24pub_type
临床试验,杂志文章abstract:BACKGROUND:Vascular endothelial growth factor (VEGF) helps control tumour growth via causing new capillaries growth in tumours. Four cardiac hormones [i.e. vessel dilator, long-acting natriuretic peptide (LANP), kaliuretic peptide (KP) and atrial natriuretic peptide (ANP)] that eliminate up to up to 86% of human small-...
journal_title:European journal of clinical investigation
pub_type: 杂志文章
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journal_title:European journal of clinical investigation
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journal_title:European journal of clinical investigation
pub_type: 杂志文章
doi:10.1111/j.1365-2362.1992.tb01458.x
更新日期:1992-04-01 00:00:00
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更新日期:2019-07-01 00:00:00
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更新日期:2017-06-01 00:00:00
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journal_title:European journal of clinical investigation
pub_type: 杂志文章
doi:10.1111/j.1365-2362.1993.tb00765.x
更新日期:1993-04-01 00:00:00
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journal_title:European journal of clinical investigation
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doi:10.1111/j.1365-2362.1988.tb01258.x
更新日期:1988-06-01 00:00:00
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journal_title:European journal of clinical investigation
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journal_title:European journal of clinical investigation
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1996-08-01 00:00:00
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journal_title:European journal of clinical investigation
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更新日期:2009-06-01 00:00:00
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journal_title:European journal of clinical investigation
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journal_title:European journal of clinical investigation
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更新日期:2012-12-01 00:00:00
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journal_title:European journal of clinical investigation
pub_type: 杂志文章
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journal_title:European journal of clinical investigation
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2003-08-01 00:00:00
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journal_title:European journal of clinical investigation
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更新日期:2012-08-01 00:00:00
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journal_title:European journal of clinical investigation
pub_type: 杂志文章
doi:10.1111/j.1365-2362.1992.tb01435.x
更新日期:1992-11-01 00:00:00
abstract::The activity of delta-aminolaevulinate synthase was determined in the livers of fed female rats and was found to vary with the phase of their sexual cycle. The highest enzymic activity was obtained during preoestrus (38.0 +/- 3.2 nmol delta-aminolaevulinateg.g liver.-1 hour-1), the lowest during dioestrus (17.4 +/- 3....
journal_title:European journal of clinical investigation
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更新日期:1976-09-10 00:00:00